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RBD and Non-synuclein Neurodegenerative Disorders: A Critical Appraisal

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Rapid-Eye-Movement Sleep Behavior Disorder

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Abstract

RBD has been proposed as an early marker of neurodegenerative diseases especially synucleinopathies, while less commonly an association has been reported between RBD and tauopathies. The RBD occurrence in disorders where there is substantial pathology in areas known to control motor aspects of REM sleep indicates that the site of neurological damage is more important that the molecular pathology. Moreover, there is a frequent overlap between synucleinopathies and tauopathies from the neuropathological standpoint. Considering together all the neurodegenerative encephalopathies, with the exception of Wilson’s disease, the most consistence feature seems that RBD associated with non-synuclein disorders occurs after the clinical disease is present, rather than before the onset of non-synuclein disorders.

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  1. Division of Neuroscience, Sleep Disorders Center, Università Vita-Salute San Raffaele, Milan, Italy

    Luigi Ferini-Strambi, Francesca Marta Casoni & Marco Zucconi

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  1. Luigi Ferini-Strambi
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  2. Francesca Marta Casoni
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  3. Marco Zucconi
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Correspondence to Luigi Ferini-Strambi .

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Editors and Affiliations

  1. Minnesota Regional Sleep Disorders Center, Departments of Psychiatry, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis, MN, USA

    Carlos H. Schenck

  2. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria

    Birgit Högl

  3. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Aleksandar Videnovic

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Ferini-Strambi, L., Casoni, F.M., Zucconi, M. (2019). RBD and Non-synuclein Neurodegenerative Disorders: A Critical Appraisal. In: Schenck, C., Högl, B., Videnovic, A. (eds) Rapid-Eye-Movement Sleep Behavior Disorder. Springer, Cham. https://doi.org/10.1007/978-3-319-90152-7_7

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  • DOI: https://doi.org/10.1007/978-3-319-90152-7_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-90151-0

  • Online ISBN: 978-3-319-90152-7

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