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REM Sleep Behavior Disorder Associated with Dementia with Lewy Bodies

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Rapid-Eye-Movement Sleep Behavior Disorder

Abstract

Several reports involving idiopathic RBD patients followed prospectively have shown that alpha-synucleinopathy phenoconversion occurs in >80% of cases, with most patients evolving to dementia with Lewy bodies (DLB) or Parkinson’s disease cases. The recent 4th Consensus Conference for the Diagnostic Criteria for DLB elevated the presence of RBD as a fourth core feature for the diagnosis of DLB. Three quarters of published DLB cases include RBD.

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Acknowledgments

Supported by grants R01 AG 015866, P50 AG 016574, U01 AG 006786, P50 NS40256, U01 NS100620 and R34 AG056639, the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program of the Mayo Foundation, the Mangurian Foundation for Lewy Body Dementia Research, the Deal Family Foundation and the Little Family Foundation.

Note Added in Proof: Two recent pertinent publications: 1. Savica R, Boeve BF, Mielke MM. When do α-synucleinopathies start? An epidemiological timeline: A review. JAMA Neurol 2018;75(4):503-509. doi: 10.1001/jamaneurol.2017.4243. 2. Marchand DG, Postuma RB, Escudier F, De Roy J, Pelletier A, Montplaisir J, Gagnon JF. How does dementia with Lewy bodies start? Prodromal cognitive changes in REM sleep behavior disorder. Ann Neurol 2018; doi: 10.1002/ana.25239.

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Authors and Affiliations

  1. Department of Neurology and Center for Sleep Medicine, Mayo Clinic, Rochester, MN, USA

    Bradley F. Boeve

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  1. Bradley F. Boeve
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Correspondence to Bradley F. Boeve .

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Editors and Affiliations

  1. Minnesota Regional Sleep Disorders Center, Departments of Psychiatry, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis, MN, USA

    Carlos H. Schenck

  2. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria

    Birgit Högl

  3. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Aleksandar Videnovic

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Boeve, B.F. (2019). REM Sleep Behavior Disorder Associated with Dementia with Lewy Bodies. In: Schenck, C., Högl, B., Videnovic, A. (eds) Rapid-Eye-Movement Sleep Behavior Disorder. Springer, Cham. https://doi.org/10.1007/978-3-319-90152-7_6

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  • DOI: https://doi.org/10.1007/978-3-319-90152-7_6

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