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Gastrointestinal Tract

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Precision Molecular Pathology of Neoplastic Pediatric Diseases

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Abstract

Polyps and tumors of the pediatric gastrointestinal tract may have unique associations with developmental and syndromic disorders, the early recognition of which may be critical in clinical management. Recently modern molecular genetic techniques have been brought to bear on these entities, revolutionizing our ability to make more precise diagnoses, offering the opportunity for novel treatments. This chapter focuses on the main pathologic and molecular genetic features associated with pediatric gastrointestinal polyps and masses. Major entities covered in this chapter include gastrointestinal stromal tumor (GIST), juvenile polyposis, familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome, Cronkhite-Canada syndrome, and PTEN hamartoma tumor syndrome. Each section includes discussion of the clinical presentation, pathology, and molecular genetic features of each entity.

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  1. Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Bruce R. Pawel MD

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Correspondence to Bruce R. Pawel MD .

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  1. Department of Pathology, University of Utah/ARUP Laboratories, Salt Lake City, Utah, USA

    Larissa V. Furtado

  2. Department of Pathology, University of Chicago, Chicago, Illinois, USA

    Aliya N. Husain

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Pawel, B.R. (2018). Gastrointestinal Tract. In: Furtado, L., Husain, A. (eds) Precision Molecular Pathology of Neoplastic Pediatric Diseases . Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-89626-7_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-89625-0

  • Online ISBN: 978-3-319-89626-7

  • eBook Packages: MedicineMedicine (R0)

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