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Skin, Melanocytic Neoplasms

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Precision Molecular Pathology of Neoplastic Pediatric Diseases

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Abstract

There has been an explosion of molecular data on melanocytic neoplasms in recent years, emerging from studies utilizing a variety of methods that include whole genome or exome sequencing, targeted sequencing, comparative genomic hybridization (CGH), and fluorescence in situ hybridization (FISH). These data have greatly enhanced our understanding of melanocytic tumor biology and have resulted in new therapeutic targets. Nevertheless, the role for molecular diagnostic testing of melanocytic lesions remains undefined, and histopathological analysis remains of primary importance in the diagnosis and management of melanocytic neoplasms. This chapter presents the relevant molecular data and indications for its use as a diagnostic aid within the context of clinical and histopathologic findings.

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Author information

Authors and Affiliations

  1. Duke University Medical Center, Durham, NC, USA

    Kristen M. Paral MD

  2. University of Chicago Medicine, Chicago, IL, USA

    Thomas Krausz MD, FRCPath

Authors
  1. Kristen M. Paral MD
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  2. Thomas Krausz MD, FRCPath
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Corresponding author

Correspondence to Kristen M. Paral MD .

Editor information

Editors and Affiliations

  1. Department of Pathology, University of Utah/ARUP Laboratories, Salt Lake City, Utah, USA

    Larissa V. Furtado

  2. Department of Pathology, University of Chicago, Chicago, Illinois, USA

    Aliya N. Husain

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Paral, K.M., Krausz, T. (2018). Skin, Melanocytic Neoplasms. In: Furtado, L., Husain, A. (eds) Precision Molecular Pathology of Neoplastic Pediatric Diseases . Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-89626-7_10

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  • DOI: https://doi.org/10.1007/978-3-319-89626-7_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-89625-0

  • Online ISBN: 978-3-319-89626-7

  • eBook Packages: MedicineMedicine (R0)

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