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Role of Histamine in Inflammatory Diseases

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Immunopharmacology and Inflammation

Abstract

Histamine plays a major role in inflammation associated with many different diseases, including allergies, autoimmune diseases and cancer, but it also has important physiological effects. Although mast cells and basophils are the main sources of histamine it can be differentially produced and released by enterochromaffin-like cells, certain nerve cells, and even neutrophils in certain pathological settings. This chapter highlights the recent developments regarding the major contributions of histamine to inflammation by acting not only through H1-receptors (H1R) but also H2R and H4R. These receptors determine both the severity of inflammation and also have immunomodulatory effects in various lymphocytes. Recent evidence also suggests a dual role for histamine in various autoimmune inflammatory disease and certain cancers, where differential receptor expressions for the amine determine the severity of these diseases but also play a role in tumour surveillance.

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Authors and Affiliations

  1. School of Pharmacy, University of Kent, Kent, UK

    Anette T. Hansen Selnø & Vadim V. Sumbayev

  2. Faculty of Medicine and Health Sciences (Dermatology, W16), Department of Dermatology and Allergy, University of Oldenburg, Oldenburg, Germany

    Ulrike Raap & Bernhard F. Gibbs

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  1. Anette T. Hansen Selnø
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  2. Vadim V. Sumbayev
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  3. Ulrike Raap
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  4. Bernhard F. Gibbs
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Correspondence to Bernhard F. Gibbs .

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Editors and Affiliations

  1. Department of Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy

    Carlo Riccardi

  2. Pharmacology and Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    Francesca Levi-Schaffer

  3. Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Ekaterini Tiligada

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Hansen Selnø, A.T., Sumbayev, V.V., Raap, U., Gibbs, B.F. (2018). Role of Histamine in Inflammatory Diseases. In: Riccardi, C., Levi-Schaffer, F., Tiligada, E. (eds) Immunopharmacology and Inflammation. Springer, Cham. https://doi.org/10.1007/978-3-319-77658-3_4

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