Abstract
In the k-mappability problem, we are given a string x of length n and integers m and k, and we are asked to count, for each length-m factor y of x, the number of other factors of length m of x that are at Hamming distance at most k from y. We focus here on the version of the problem where \(k=1\). The fastest known algorithm for \(k=1\) requires time \(\mathcal {O}(mn \log n/\log \log n)\) and space \(\mathcal {O}(n)\). We present two new algorithms that require worst-case time \(\mathcal {O}(mn)\) and \(\mathcal {O}(n \log n \log \log n)\), respectively, and space \(\mathcal {O}(n)\), thus greatly improving the state of the art. Moreover, we present another algorithm that requires average-case time and space \(\mathcal {O}(n)\) for integer alphabets of size \(\sigma \) if \(m=\varOmega (\log _\sigma n)\). Notably, we show that this algorithm is generalizable for arbitrary k, requiring average-case time \(\mathcal {O}(kn)\) and space \(\mathcal {O}(n)\) if \(m=\varOmega (k\log _\sigma n)\).
M. Alzamel and C.S. Iliopoulos—Partially supported by the Onassis Foundation.
J. Radoszewski—Supported by the “Algorithms for text processing with errors and uncertainties” project carried out within the HOMING programme of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Amir, A., Landau, G.M., Lewenstein, M., Sokol, D.: Dynamic text and static pattern matching. ACM Trans. Algor. 3(2), 19 (2007). http://doi.acm.org/10.1145/1240233.1240242
Antoniou, P., Daykin, J.W., Iliopoulos, C.S., Kourie, D., Mouchard, L., Pissis, S.P.: Mapping uniquely occurring short sequences derived from high throughput technologies to a reference genome. In: 2009 9th International Conference on Information Technology and Applications in Biomedicine, pp. 1–4. IEEE Computer Society (2009). https://doi.org/10.1109/ITAB.2009.5394394
Bender, M.A., Farach-Colton, M.: The LCA problem revisited. In: Gonnet, G.H., Viola, A. (eds.) LATIN 2000. LNCS, vol. 1776, pp. 88–94. Springer, Heidelberg (2000). https://doi.org/10.1007/10719839_9
Cole, R., Gottlieb, L., Lewenstein, M.: Dictionary matching and indexing with errors and don’t cares. In: Babai, L. (ed.) Proceedings of the 36th Annual ACM Symposium on Theory of Computing, 2004, pp. 91–100. ACM (2004). http://doi.acm.org/10.1145/1007352.1007374
Crochemore, M., Tischler, G.: The gapped suffix array: a new index structure for fast approximate matching. In: Chavez, E., Lonardi, S. (eds.) SPIRE 2010. LNCS, vol. 6393, pp. 359–364. Springer, Heidelberg (2010). https://doi.org/10.1007/978-3-642-16321-0_37
Derrien, T., Estellé, J., Marco Sola, S., Knowles, D., Raineri, E., Guigó, R., Ribeca, P.: Fast computation and applications of genome mappability. PLoS ONE 7(1), e30377 (2012). https://doi.org/10.1371/journal.pone.0030377
Farach, M.: Optimal suffix tree construction with large alphabets. In: 38th Annual Symposium on Foundations of Computer Science, FOCS 1997, pp. 137–143. IEEE Computer Society (1997). https://doi.org/10.1109/SFCS.1997.646102
Fischer, J.: Inducing the LCP-array. In: Dehne, F., Iacono, J., Sack, J.-R. (eds.) WADS 2011. LNCS, vol. 6844, pp. 374–385. Springer, Heidelberg (2011). https://doi.org/10.1007/978-3-642-22300-6_32
Fischer, J., Köppl, D., Kurpicz, F.: On the benefit of merging suffix array intervals for parallel pattern matching. In: Grossi, R., Lewenstein, M. (eds.) 27th Annual Symposium on Combinatorial Pattern Matching, CPM 2016. LIPIcs, vol. 54, pp. 26:1–26:11. Schloss Dagstuhl - Leibniz-Zentrum fuer Informatik (2016). https://doi.org/10.4230/LIPIcs.CPM.2016.26
Fonseca, N.A., Rung, J., Brazma, A., Marioni, J.C.: Tools for mapping high-throughput sequencing data. Bioinformatics 28(24), 3169–3177 (2012). https://doi.org/10.1093/bioinformatics/bts605
Fredman, M.L., Komlós, J., Szemerédi, E.: Storing a sparse table with O(1) worst case access time. J. ACM 31(3), 538–544 (1984). http://doi.acm.org/10.1145/828.1884
Manber, U., Myers, E.W.: Suffix arrays: a new method for on-line string searches. SIAM J. Comput. 22(5), 935–948 (1993). https://doi.org/10.1137/0222058
Manzini, G.: Longest common prefix with mismatches. In: Iliopoulos, C., Puglisi, S., Yilmaz, E. (eds.) SPIRE 2015. LNCS, vol. 9309, pp. 299–310. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-23826-5_29
Metzker, M.L.: Sequencing technologies - the next generation. Nat. Rev. Genet. 11(1), 31–46 (2010). https://doi.org/10.1038/nrg2626
Nong, G., Zhang, S., Chan, W.H.: Linear suffix array construction by almost pure induced-sorting. In: Storer, J.A., Marcellin, M.W. (eds.) 2009 Data Compression Conference (DCC 2009), pp. 193–202. IEEE Computer Society (2009). https://doi.org/10.1109/DCC.2009.42
Thankachan, S.V., Apostolico, A., Aluru, S.: A provably efficient algorithm for the k-mismatch average common substring problem. J. Comput. Biol. 23(6), 472–482 (2016). https://doi.org/10.1089/cmb.2015.0235
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this paper
Cite this paper
Alzamel, M., Charalampopoulos, P., Iliopoulos, C.S., Pissis, S.P., Radoszewski, J., Sung, WK. (2017). Faster Algorithms for 1-Mappability of a Sequence. In: Gao, X., Du, H., Han, M. (eds) Combinatorial Optimization and Applications. COCOA 2017. Lecture Notes in Computer Science(), vol 10628. Springer, Cham. https://doi.org/10.1007/978-3-319-71147-8_8
Download citation
DOI: https://doi.org/10.1007/978-3-319-71147-8_8
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-71146-1
Online ISBN: 978-3-319-71147-8
eBook Packages: Computer ScienceComputer Science (R0)