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Right–Left Ventricular Interactions in RV Afterload and Preload

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Right Ventricular Physiology, Adaptation and Failure in Congenital and Acquired Heart Disease

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Abstract

Ventricular–ventricular interactions refer to the cumulative effect of changes in filling, function, geometry and synchrony of one ventricle on the filling, function, geometry and synchrony of the contra-lateral ventricle. A substantial portion of RV mechanical work under normal circumstances is generated by LV contraction. However, the RV also profoundly influences LV function. These RV to LV and LV to RV interactions, are particularly prominent during increased volume and pressure loading, and affect disease course and outcome. These ventricular–ventricular interactions may also be recruited and targeted for therapeutic benefit. For example, controlled pulmonary artery banding in dilated cardiomyopathy and aortic banding in pulmonary hypertension may augment the function of the failing left and right ventricle respectively. Even in single ventricle physiology, the hypoplastic ventricle can affect the function of the dominant ventricle. In this chapter we review the physiology, pathophysiology and therapeutic benefit of ventricular–ventricular interactions.

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Authors and Affiliations

  1. Paediatric Cardiology, Labatt Family Heart Center Hospital for Sick Children, Toronto, Ontario, Canada

    Mark K. Friedberg

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  1. Mark K. Friedberg
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Correspondence to Mark K. Friedberg .

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Editors and Affiliations

  1. Paediatric Cardiology, Labatt Family Heart Center Hospital for Sick Children, Toronto, Ontario, Canada

    Mark K. Friedberg

  2. Heart Institute, Cincinnati Children’s Hosp Med Center, Cincinnati, Ohio, USA

    Andrew N. Redington

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Friedberg, M.K. (2018). Right–Left Ventricular Interactions in RV Afterload and Preload. In: Friedberg, M., Redington, A. (eds) Right Ventricular Physiology, Adaptation and Failure in Congenital and Acquired Heart Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-67096-6_6

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  • DOI: https://doi.org/10.1007/978-3-319-67096-6_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67094-2

  • Online ISBN: 978-3-319-67096-6

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