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Embryological Origins: How Does the Right Ventricle Form

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Right Ventricular Physiology, Adaptation and Failure in Congenital and Acquired Heart Disease

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Abstract

The heart originates from a group of cardiac progenitor cells that form the cardiac tube, which develops into a complex four-chambered beating organ. Several tissues signal to stimulate cardiac progenitors to acquire cell fate and differentiate. The timing of differentiation of cardiac progenitors defines the first and second heart fields. The first heart field gives rise to the left ventricle. The second heart field, located anterior to the first heart field, is added to the cardiac tube to give rise mainly to the outflow tract and the right ventricle. Several epigenetic mechanisms including histone and DNA methylation stabilize the transcriptional programs controlling cardiac development.

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Acknowledgements

P.D.O. is funded by the Heart and Stroke Foundation of Canada (G-17-0018613), Operational Funds from the Hospital for Sick Children, the Natural Sciences and Engineering Research Council of Canada (NSERC) (500865), and the Canadian Institutes of Health Research (CIHR) (PJT-149046). The author thanks Koroboshka Brand-Arzamendi for graphics.

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  1. Translational Medicine, Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, 686 Bay St Room 10-9715, Toronto, ON, Canada, M5G 0A4

    Paul Delgado-Olguín

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  1. Paul Delgado-Olguín
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Correspondence to Paul Delgado-Olguín .

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  1. Paediatric Cardiology, Labatt Family Heart Center Hospital for Sick Children, Toronto, Ontario, Canada

    Mark K. Friedberg

  2. Heart Institute, Cincinnati Children’s Hosp Med Center, Cincinnati, Ohio, USA

    Andrew N. Redington

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Delgado-Olguín, P. (2018). Embryological Origins: How Does the Right Ventricle Form. In: Friedberg, M., Redington, A. (eds) Right Ventricular Physiology, Adaptation and Failure in Congenital and Acquired Heart Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-67096-6_1

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  • DOI: https://doi.org/10.1007/978-3-319-67096-6_1

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