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Solid-Binding Peptides in Biomedicine

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Peptides and Peptide-based Biomaterials and their Biomedical Applications

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1030))

Abstract

Some peptides are able to bind to inorganic materials such as silica and gold. Over the past decade, Solid-binding peptides (SBPs) have been used increasingly as molecular building blocks in nanobiotechnology. These peptides show selectivity and bind with high affinity to a diverse range of inorganic surfaces e.g. metals, metal oxides, metal compounds, magnetic materials, semiconductors, carbon materials, polymers and minerals. They can be used in applications such as protein purification and synthesis, assembly and the functionalization of nanomaterials. They offer simple and versatile bioconjugation methods that can increase biocompatibility and also direct the immobilization and orientation of nanoscale entities onto solid supports without impeding their functionality. SBPs have been employed in numerous nanobiotechnological applications such as the controlled synthesis of nanomaterials and nanostructures, formation of hybrid biomaterials, immobilization of functional proteins and improved nanomaterial biocompatibility. With advances in nanotechnology, a multitude of novel nanomaterials have been designed and synthesized for diagnostic and therapeutic applications. New approaches have been developed recently to exert a greater control over bioconjugation and eventually, over the optimal and functional display of biomolecules on the surfaces of many types of solid materials. In this chapter we describe SBPs and highlight some selected examples of their potential applications in biomedicine.

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References

  • Akerström B, Björck L (1989) Protein L: an immunoglobulin light chain-binding bacterial protein. Characterization of binding and physicochemical properties. J Biol Chem 264:19740–19746

    PubMed  Google Scholar 

  • Avvakumova S, Colombo M, Tortora P, Prosperi D (2014) Biotechnological approaches toward nanoparticle biofunctionalization. Trends Biotechnol 32:11–20

    Article  CAS  PubMed  Google Scholar 

  • Bae YH, Park K (2011) Targeted drug delivery to tumors: myths, reality and possibility. J Control Release 153:198–205

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bertrand N, Wu J, Xu X, Kamaly N, Farokhzad OC (2014) Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev 66:2–25

    Article  CAS  PubMed  Google Scholar 

  • Brown S (1997) Metal-recognition by repeating polypeptides. Nat Biotech 15:269–272

    Article  CAS  Google Scholar 

  • Brown S, Sarikaya M, Johnson E (2000) A genetic analysis of crystal growth. J Mol Biol 299:725–735

    Article  CAS  PubMed  Google Scholar 

  • Care A, Chi F, Bergquist P, Sunna A (2014a) Biofunctionalization of silica-coated magnetic particles mediated by a peptide. J Nanopart Res 16:1–9

    Article  CAS  Google Scholar 

  • Care A, Nevalainen H, Bergquist P, Sunna A (2014b) Effect of Trichoderma reesei proteinases on the affinity of an inorganic-binding peptide. Appl Biochem Biotechnol 173:2225–2240

    Article  CAS  PubMed  Google Scholar 

  • Care A, Bergquist PL, Sunna A (2015) Solid-binding peptides: smart tools for nanobiotechnology. Trends Biotechnol 33:259–268

    Article  CAS  PubMed  Google Scholar 

  • Chen G, Qiu H, Prasad PN, Chen X (2014) Upconversion nanoparticles: design, nanochemistry, and applications in theranostics. Chem Rev 114:5161–5214

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chiu D, Zhou W, Kitayaporn S, Schwartz DT, Murali-Krishna K, Kavanagh TJ, Baneyx F (2012) Biomineralization and size control of stable calcium phosphate core–protein shell nanoparticles: potential for vaccine applications. Bioconjug Chem 23:610–617

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cho N-H, Cheong T-C, Min JH, Wu JH, Lee SJ, Kim D, Yang J-S, Kim S, Kim YK, Seong S-Y (2011) A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. Nat Nano 6:675–682

    Article  CAS  Google Scholar 

  • Chung W-J, Kwon K-Y, Song J, Lee S-W (2011) Evolutionary screening of collagen-like peptides that nucleate hydroxyapatite crystals. Langmuir 27:7620–7628

    Article  CAS  PubMed  Google Scholar 

  • Corni S, Hnilova M, Tamerler C, Sarikaya M (2013) Conformational behavior of genetically-engineered dodecapeptides as a determinant of binding affinity for gold. J Phys Chem C Nanomater Interfaces 117:16990–17003

    Article  CAS  Google Scholar 

  • Cui Y, Kim SN, Jones SE, Wissler LL, Naik RR, McAlpine MC (2010) Chemical functionalization of graphene enabled by phage displayed peptides. Nano Lett 10:4559–4565

    Article  CAS  PubMed  Google Scholar 

  • Dang X, Yi H, Ham M-H, Qi J, Yun DS, Ladewski R, Strano MS, Hammond PT, Belcher AM (2011) Virus-templated self-assembled single-walled carbon nanotubes for highly efficient electron collection in photovoltaic devices. Nat Nano 6:377–384

    Article  CAS  Google Scholar 

  • de Juan-Franco E, Caruz A, Pedrajas J, Lechuga LM (2013) Site-directed antibody immobilization using a protein A–gold binding domain fusion protein for enhanced SPR immunosensing. Analyst 138:2023–2031

    Article  PubMed  Google Scholar 

  • de Oliveira PT, Zalzal SF, Beloti MM, Rosa AL, Nanci A (2007) Enhancement of in vitro osteogenesis on titanium by chemically produced nanotopography. J Biomed Mater Res A 80:554–564

    Article  PubMed  Google Scholar 

  • Eteshola E, Brillson LJ, Lee SC (2005) Selection and characteristics of peptides that bind thermally grown silicon dioxide films. Biomol Eng 22:201–204

    Article  CAS  PubMed  Google Scholar 

  • Flynn CE, Mao C, Hayhurst A, Williams JL, Georgiou G, Iverson B, Belcher AM (2003) Synthesis and organization of nanoscale II-VI semiconductor materials using evolved peptide specificity and viral capsid assembly. J Mater Chem 13:2414–2421

    Article  CAS  Google Scholar 

  • Ghosh D, Bagley AF, Na YJ, Birrer MJ, Bhatia SN, Belcher AM (2014) Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes. Proc Natl Acad Sci U S A 111:13948–13953

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Giessen TW, Silver PA (2016) Converting a natural protein compartment into a nanofactory for the size-constrained synthesis of antimicrobial silver nanoparticles. ACS Synth Biol 5:1497–1504

    Article  CAS  PubMed  Google Scholar 

  • Goede K, Busch P, Grundmann M (2004) Binding specificity of a peptide on semiconductor surfaces. Nano Lett 4:2115–2120

    Article  CAS  Google Scholar 

  • Gogoladze G, Grigolava M, Vishnepolsky B, Chubinidze M, Duroux P, Lefranc M-P, Pirtskhalava M (2014) DBAASP: database of antimicrobial activity and structure of peptides. FEMS Microbiol Lett 357:63–68

    Article  CAS  PubMed  Google Scholar 

  • Gungormus M, Fong H, Kim IW, Evans JS, Tamerler C, Sarikaya M (2008) Regulation of in vitro calcium phosphate mineralization by combinatorially selected hydroxyapatite-binding peptides. Biomacromolecules 9:966–973

    Article  CAS  PubMed  Google Scholar 

  • Ha N-Y, Shin HM, Sharma P, Cho HA, Min C-K, H-i K, Yen NTH, Kang J-S, Kim I-S, Choi M-S, Kim YK, Cho N-H (2016) Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen. J Nanobiotechnol 14:76

    Article  Google Scholar 

  • Hnilova M, Oren EE, Seker UOS, Wilson BR, Collino S, Evans JS, Tamerler C, Sarikaya M (2008) Effect of molecular conformations on the adsorption behavior of gold-binding peptides. Langmuir 24:12440–12445

    Article  CAS  PubMed  Google Scholar 

  • Hochuli E, Bannwarth W, Döbeli H, Gentz R, Stüber D (1988) Genetic approach to facilitate purification of recombinant proteins with a novel metal chelate adsorbent. Nat Biotechnol 6:1321–1325

    Article  CAS  Google Scholar 

  • Huang Y, Chiang C-Y, Lee SK, Gao Y, Hu EL, Yoreo JD, Belcher AM (2005) Programmable assembly of nanoarchitectures using genetically engineered viruses. Nano Lett 5:1429–1434

    Article  CAS  PubMed  Google Scholar 

  • Huang J, Ru B, Zhu P, Nie F, Yang J, Wang X, Dai P, Lin H, Guo F-B, Rao N (2012) MimoDB 2.0: a mimotope database and beyond. Nucleic Acids Res 40:D271–D277

    Article  CAS  PubMed  Google Scholar 

  • Huang Z-B, Shi X, Mao J, S-q G (2016) Design of a hydroxyapatite-binding antimicrobial peptide with improved retention and antibacterial efficacy for oral pathogen control. Sci Rep 6:38410

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kase D, Kulp JL, Yudasaka M, Evans JS, Iijima S, Shiba K (2004) Affinity selection of peptide phage libraries against single-wall carbon nanohorns identifies a peptide aptamer with conformational variability. Langmuir 20:8939–8941

    Article  CAS  PubMed  Google Scholar 

  • Kelly M, Williams R, Aojula A, O'Neill J, Trzińscka Z, Grover L, Scott RA, Peacock AF, Logan A, Stamboulis A (2015) Peptide aptamers: novel coatings for orthopaedic implants. Mater Sci Eng C Mater Biol Appl 54:84–93

    Article  CAS  PubMed  Google Scholar 

  • Khatayevich D, Gungormus M, Yazici H, So C, Cetinel S, Ma H, Jen A, Tamerler C, Sarikaya M (2010) Biofunctionalization of materials for implants using engineered peptides. Acta Biomater 6:4634–4641

    Article  CAS  PubMed  Google Scholar 

  • Kim J, Rheem Y, Yoo B, Chong Y, Bozhilov KN, Kim D, Sadowsky MJ, Hur H-G, Myung NV (2010) Peptide-mediated shape- and size-tunable synthesis of gold nanostructures. Acta Biomater 6:2681–2689

    Article  CAS  PubMed  Google Scholar 

  • Ko S, Park TJ, Kim H-S, Kim J-H, Cho Y-J (2009) Directed self-assembly of gold binding polypeptide-protein A fusion proteins for development of gold nanoparticle-based SPR immunosensors. Biosens Bioelectron 24:2592–2597

    Article  CAS  PubMed  Google Scholar 

  • Kröger N, Deutzmann R, Sumper M (1999) Polycationic peptides from diatom biosilica that direct silica nanosphere formation. Science 286:1129–1132

    Article  PubMed  Google Scholar 

  • Li Y, Huang Y (2010) Morphology-controlled synthesis of platinum nanocrystals with specific peptides. Adv Mater Res 22:1921–1925

    Article  CAS  Google Scholar 

  • Liang L, Care A, Zhang R, Lu Y, Packer NH, Sunna A, Qian Y, Zvyagin AV (2016) Facile assembly of functional upconversion nanoparticles for targeted cancer imaging and photodynamic therapy. ACS Appl Mater Interfaces 8:11945–11953

    Article  CAS  PubMed  Google Scholar 

  • Liang L, Lu Y, Zhang R, Care A, Ortega TA, Deyev SM, Qian Y, Zvyagin AV (2017) Deep-penetrating photodynamic therapy with KillerRed mediated by upconversion nanoparticles. Acta Biomater 51:461–470

    Article  CAS  PubMed  Google Scholar 

  • Lu Y, Zhao J, Zhang R, Liu Y, Liu D, Goldys EM, Yang X, Xi P, Sunna A, Lu J, Shi Y, Leif RC, Huo Y, Shen J, Piper JA, Robinson JP, Jin D (2014) Tunable lifetime multiplexing using luminescent nanocrystals. Nat Photon 8:32–36

    Article  CAS  Google Scholar 

  • Lucky SS, Soo KC, Zhang Y (2015) Nanoparticles in photodynamic therapy. Chem Rev 115:1990–2042

    Article  CAS  PubMed  Google Scholar 

  • Mann JA, Dichtel WR (2013) Noncovalent functionalization of graphene by molecular and polymeric adsorbates. J Phys Chem Lett 4:2649–2657

    Article  CAS  Google Scholar 

  • Mannoor MS, Tao H, Clayton JD, Sengupta A, Kaplan DL, Naik RR, Verma N, Omenetto FG, McAlpine MC (2012) Graphene-based wireless bacteria detection on tooth enamel. Nat Commun 3:763

    Article  PubMed  Google Scholar 

  • Mao C, Flynn CE, Hayhurst A, Sweeney R, Qi J, Georgiou G, Iverson B, Belcher AM (2003) Viral assembly of oriented quantum dot nanowires. Proc Natl Acad Sci U S A 100:6946–6951

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Naik RR, Brott LL, Clarson SJ, Stone MO (2002a) Silica-precipitating peptides isolated from a combinatorial phage display peptide library. J Nanosci Nanotechnol 2:95–100

    Article  CAS  PubMed  Google Scholar 

  • Naik RR, Stringer SJ, Agarwal G, Jones SE, Stone MO (2002b) Biomimetic synthesis and patterning of silver nanoparticles. Nat Mater 1:169–172

    Article  CAS  PubMed  Google Scholar 

  • Nam KT, Kim D-W, Yoo PJ, Chiang C-Y, Meethong N, Hammond PT, Chiang Y-M, Belcher AM (2006) Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes. Science 312:885–888

    Article  CAS  PubMed  Google Scholar 

  • Nel AE, Madler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, Klaessig F, Castranova V, Thompson M (2009) Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8:543–557

    Article  CAS  PubMed  Google Scholar 

  • Nochomovitz R, Amit M, Matmor M, Ashkenasy N (2010) Bioassisted multi-nanoparticle patterning using single-layer peptide templates. Nanotechnology 21:145305

    Article  PubMed  Google Scholar 

  • Nygaard S, Wendelbo R, Brown S (2002) Surface-specific zeolite-binding proteins. Adv Mater Res 14:1853–1856

    Article  CAS  Google Scholar 

  • Oren EE, Tamerler C, Sahin D, Hnilova M, Seker UOS, Sarikaya M, Samudrala R (2007) A novel knowledge-based approach to design inorganic-binding peptides. Bioinformatics 23:2816–2822

    Article  CAS  PubMed  Google Scholar 

  • Pacardo DB, Sethi M, Jones SE, Naik RR, Knecht MR (2009) Biomimetic synthesis of Pd nanocatalysts for the Stille coupling reaction. ACS Nano 3:1288–1296

    Article  CAS  PubMed  Google Scholar 

  • Park TJ, Zheng S, Kang YJ, Lee SY (2009) Development of a whole-cell biosensor by cell surface display of a gold-binding polypeptide on the gold surface. FEMS Microbiol Lett 293:141–147

    Article  CAS  PubMed  Google Scholar 

  • Pender MJ, Sowards LA, Hartgerink JD, Stone MO, Naik RR (2005) Peptide-mediated formation of single-wall carbon nanotube composites. Nano Lett 6:40–44

    Article  Google Scholar 

  • Puddu V, Perry CC (2012) Peptide adsorption on silica nanoparticles: evidence of hydrophobic interactions. ACS Nano 6:6356–6363

    Article  CAS  PubMed  Google Scholar 

  • Ramaraju H, Miller SJ, Kohn DH (2014) Dual-functioning phage-derived peptides encourage human bone marrow cell-specific attachment to mineralized biomaterials. Connect Tissue Res 55:160–163

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sano K, Shiba K (2003) A hexapeptide motif that electrostatically binds to the surface of titanium. J Am Chem Soc 125:14234–14235

    Article  CAS  PubMed  Google Scholar 

  • Sarikaya M, Tamerler C, Jen AKY, Schulten K, Baneyx F (2003) Molecular biomimetics: nanotechnology through biology. Nat Mater 2:577–585

    Article  CAS  PubMed  Google Scholar 

  • Sayyadi N, Care A, Connally RE, Try AC, Bergquist PL, Sunna A (2016) A novel universal detection agent for time-gated luminescence bioimaging. Sci Rep 6:27564

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Seker UOS, Wilson B, Sahin D, Tamerler C, Sarikaya M (2008) Quantitative affinity of genetically engineered repeating polypeptides to inorganic surfaces. Biomacromolecules 10:250–257

    Article  Google Scholar 

  • Singh R, Lillard JW (2009) Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86:215–223

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sunna A, Chi F, Bergquist PL (2013a) Efficient capture of pathogens with a zeolite matrix. Parasitol Res 112:2441–2452

    Article  PubMed  Google Scholar 

  • Sunna A, Chi F, Bergquist PL (2013b) A linker peptide with high affinity towards silica-containing materials. New Biotechnol 30:485–492

    Article  CAS  Google Scholar 

  • Tang Z, Palafox-Hernandez JP, Law W-C, Hughes ZE, Swihart MT, Prasad PN, Knecht MR, Walsh TR (2013) Biomolecular recognition principles for bionanocombinatorics: an integrated approach to elucidate enthalpic and entropic factors. ACS Nano 7:9632–9646

    Article  CAS  PubMed  Google Scholar 

  • Thai CK, Dai H, Sastry MSR, Sarikaya M, Schwartz DT, Baneyx F (2004) Identification and characterization of Cu2O- and ZnO-binding polypeptides by Escherichia coli cell surface display: toward an understanding of metal oxide binding. Biotechnol Bioeng 87:129–137

    Article  CAS  PubMed  Google Scholar 

  • Tyagi A, Tuknait A, Anand P, Gupta S, Sharma M, Mathur D, Joshi A, Singh S, Gautam A, Raghava GPS (2015) CancerPPD: a database of anticancer peptides and proteins. Nucleic Acids Res 43:D837–D843

    Article  CAS  PubMed  Google Scholar 

  • Umetsu M, Mizuta M, Tsumoto K, Ohara S, Takami S, Watanabe H, Kumagai I, Adschiri T (2005) Bioassisted room-temperature immobilization and mineralization of zinc oxide—the structural ordering of ZnO nanoparticles into a flower-type morphology. Adv Mater Res 17:2571–2575

    Article  CAS  Google Scholar 

  • Umlauf BJ, McGuire MJ, Brown KC (2014) Introduction of plasmid encoding for rare tRNAs reduces amplification bias in phage display biopanning. BioTechniques 58:81

    Google Scholar 

  • Whaley SR, English DS, Hu EL, Barbara PF, Belcher AM (2000) Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly. Nature 405:665–668

    Article  CAS  PubMed  Google Scholar 

  • Yazici H, Fong H, Wilson B, Oren EE, Amos FA, Zhang H, Evans JS, Snead ML, Sarikaya M, Tamerler C (2013) Biological response on a titanium implant-grade surface functionalized with modular peptides. Acta Biomater 9:5341–5352

    Article  CAS  PubMed  Google Scholar 

  • Yazici H, O’Neill MB, Kacar T, Wilson BR, Oren EE, Sarikaya M, Tamerler C (2016) Engineered chimeric peptides as antimicrobial surface coating agents toward infection-free implants. ACS Appl Mater Interfaces 8:5070–5081

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yi X, Wang F, Qin W, Yang X, Yuan J (2014) Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field. Int J Nanomedicine 9:1347

    Article  PubMed  PubMed Central  Google Scholar 

  • Yoshinari M, Kato T, Matsuzaka K, Hayakawa T, Shiba K (2010) Prevention of biofilm formation on titanium surfaces modified with conjugated molecules comprised of antimicrobial and titanium-binding peptides. Biofouling 26:103–110

    Article  CAS  PubMed  Google Scholar 

  • Yoshinari M, Matsuzaka K, Inoue T (2011) Surface modification by cold-plasma technique for dental implants—bio-functionalization with binding pharmaceuticals. Jpn Dent Sci Rev 47:89–101

    Article  Google Scholar 

  • Yuasa K, Kokubu E, Kokubun K, Matsuzaka K, Shiba K, Kashiwagi K, Inoue T (2014) An artificial fusion protein between bone morphogenetic protein 2 and titanium-binding peptide is functional in vivo. J Biomed Mater Res A 102:1180–1186

    Article  PubMed  Google Scholar 

  • Yuca E, Karatas AY, Seker UOS, Gungormus M, Dinler-Doganay G, Sarikaya M, Tamerler C (2011) In vitro labeling of hydroxyapatite minerals by an engineered protein. Biotechnol Bioeng 108:1021–1030

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Zheng F, Yang T, Zhou W, Liu Y, Man N, Zhang L, Jin N, Dou Q, Zhang Y, Li Z, Wen L-P (2012) Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides. Nat Mater 11:817–826

    Article  CAS  PubMed  Google Scholar 

  • Zhou W, Schwartz DT, Baneyx F (2010) Single-pot biofabrication of zinc sulfide immuno-quantum dots. J Am Chem Soc 132:4731–4738

    Article  CAS  PubMed  Google Scholar 

  • Zhou W, Moguche AO, Chiu D, Murali-Krishna K, Baneyx F (2014) Just-in-time vaccines: biomineralized calcium phosphate core-immunogen shell nanoparticles induce long-lasting CD8+ T cell responses in mice. Nanomedicine 10:571–578

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, NSW, Australia

    Andrew Care

  2. ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP), Macquarie University, North Ryde, NSW, Australia

    Peter L. Bergquist & Anwar Sunna

  3. Biomolecular Discovery and Design Research Centre, Macquarie University, North Ryde, NSW, Australia

    Peter L. Bergquist

  4. Department of Molecular Medicine & Pathology, Medical School, University of Auckland, Auckland, New Zealand

    Peter L. Bergquist & Anwar Sunna

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  1. Andrew Care
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  2. Peter L. Bergquist
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Correspondence to Anwar Sunna .

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Editors and Affiliations

  1. Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia

    Anwar Sunna

  2. Biomolecular Discovery and Design, Research Centre, Macquarie University, North Ryde, New South Wales, Australia

    Andrew Care

  3. Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia

    Peter L. Bergquist

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Care, A., Bergquist, P.L., Sunna, A. (2017). Solid-Binding Peptides in Biomedicine. In: Sunna, A., Care, A., Bergquist, P. (eds) Peptides and Peptide-based Biomaterials and their Biomedical Applications. Advances in Experimental Medicine and Biology, vol 1030. Springer, Cham. https://doi.org/10.1007/978-3-319-66095-0_2

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