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Programmable Bio-surfaces for Biomedical Applications

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Peptides and Peptide-based Biomaterials and their Biomedical Applications

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1030))

Abstract

A peptide can be used as a functional building block to construct artificial systems when it has sufficient transplantability and functional independence in terms of its assigned function. Recent advances in in vitro evolution systems have been increasing the list of peptides that specifically bind to certain targets, such as proteins and cells. By properly displaying these peptides on solid surfaces, we can endow the inorganic materials with various biological functions, which will contribute to the development of diagnosis and therapeutic medical devices. Here, the methods for the peptide-based surface functionalization are reviewed by focusing on sources of peptides as well as methods of immobilization.

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Authors and Affiliations

  1. Division of Protein Engineering, The Cancer Institute of Japanese Foundation for Cancer Research, Ariake, Koto, Tokyo, 135-8550, Japan

    Kiyotaka Shiba

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  1. Kiyotaka Shiba
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  1. Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia

    Anwar Sunna

  2. Biomolecular Discovery and Design, Research Centre, Macquarie University, North Ryde, New South Wales, Australia

    Andrew Care

  3. Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, New South Wales, Australia

    Peter L. Bergquist

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Shiba, K. (2017). Programmable Bio-surfaces for Biomedical Applications. In: Sunna, A., Care, A., Bergquist, P. (eds) Peptides and Peptide-based Biomaterials and their Biomedical Applications. Advances in Experimental Medicine and Biology, vol 1030. Springer, Cham. https://doi.org/10.1007/978-3-319-66095-0_1

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