Abstract
Varicose veins are a common condition affecting a third of the population. Surgery has for a long time been the main treatment option. Over the past decade though, endovenous thermal ablation techniques have been introduced which have changed the management landscape of the disease. These are, however, often associated with discomfort during the injection of tumescent anaesthesia and the thermal treatment itself as well as potential complications from thermal injury. Non-thermal, non-tumescent (NTNT) technology can potentially avoid these problems. Vein sealing, using cyanoacrylate adhesive, is one such method. The technique and results from early clinical trials are discussed.
References
Evans CJ, et al. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh vein study. J Epidemiol Community Health. 1999;53(3):149–53.
Kurz X, et al. Do varicose veins affect quality of life? Results of an international population-based study. J Vasc Surg. 2001;34(4):641–8.
Kaplan RM, et al. Quality of life in patients with chronic venous disease: San Diego population study. J Vasc Surg. 2003;37(5):1047–53.
Beebe-Dimmer JL, et al. The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol. 2005;15(3):175–84.
Shepherd AC, et al. A study to compare disease-specific quality of life with clinical anatomical and hemodynamic assessments in patients with varicose veins. J Vasc Surg. 2011;53(2):374–82.
Durkin MT, et al. Long saphenous vein stripping and quality of life--a randomised trial. Eur J Vasc Endovasc Surg. 2001;21(6):545–9.
MacKenzie RK, et al. The effect of long saphenous vein stripping on quality of life. J Vasc Surg. 2002;35(6):1197–203.
Darvall KA, et al. Changes in health-related quality of life after ultrasound-guided foam sclerotherapy for great and small saphenous varicose veins. J Vasc Surg. 2010;51(4):913–20.
Gloviczki P, Gloviczki ML. Guidelines for the management of varicose veins. Phlebology. 2012;27(Suppl 1):2–9.
National Institute for Health and Care Excellence, NICE Clinical Guideline Centre. Varicose veins in the legs – the diagnosis and management of varicose veins (clinical guideline 168). UK: NICE; 2013.
Elias S, Lam YL, Wittens CH. Mechanochemical ablation: status and results. Phlebology. 2013;28(Suppl 1):10–4.
Almeida JI, et al. First human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. J Vasc Surg Venous Lymphat Disord. 2013;1(2):174–80.
van Eekeren RRJP, et al. Mechanochemical endovenous ablation for the treatment of great saphenous vein insufficiency. J Vasc Surg Venous Lymphat Disord. 2014;2(3):282–8.
Lane T, et al. A multi-centre randomised controlled trial comparing radiofrequency and mechanical occlusion chemically assisted ablation of varicose veins – final results of the Venefit versus Clarivein for varicose veins trial. Phlebology. 2016;32(2):89–98.
Idle MR, et al. N-butyl-2-cyanoacrylate (NBCA) tissue adhesive as a haemostatic agent in a venous malformation of the mandible. Br J Oral Maxillofac Surg. 2013;51(6):565–7.
Linfante I, Wakhloo AK. Brain aneurysms and arteriovenous malformations: advancements and emerging treatments in endovascular embolization. Stroke. 2007;38(4):1411–7.
Min RJ, et al. Novel vein closure procedure using a proprietary cyanoacrylate adhesive: 30-day swine model results. Phlebology. 2012;27(8):398–403.
Morrison N. Is cyanoacrylate safe for peripheral venous applications? Endovascular Today. 2015: pp. 78–79.
Bozkurt AK, Yilmaz MF. A prospective comparison of a new cyanoacrylate glue and laser ablation for the treatment of venous insufficiency. Phlebology. 2016;31(1 Suppl):106–13.
Kailasnath P, Chaloupka JC. Quantitative assessment of polymerization-binding mechanics of cyanoacrylates: model development and validation. AJNR Am J Neuroradiol. 2002;23(5):772–8.
Almeida JI, et al. Cyanoacrylate adhesive for the closure of truncal veins: 60-day swine model results. Vasc Endovasc Surg. 2011;45(7):631–5.
Almeida JI, et al. Two-year follow-up of first human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. Phlebology. 2015;30(6):397–404.
Proebstle TM, et al. The European multicenter cohort study on cyanoacrylate embolization of refluxing great saphenous veins. J Vasc Surg Venous Lymphat Disord. 2015;3(1):2–7.
Morrison N, et al. Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose). J Vasc Surg. 2015;61(4):985–94.
Bhat G, Suvarna D, Pai CG. Symptomatic portal biliopathy following cyanoacrylate injection for a bleeding duodenal varix. Trop Gastroenterol. 2013;34(2):108–9.
Rabe E, et al. European guidelines for sclerotherapy in chronic venous disorders. Phlebology. 2013;29(6):338–54.
National Institute for Health and Care Excellence. Interventional procedure guidance: cyanoacrylate glue occlusion for varicose veins. 2015.
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Bootun, R., Lane, T.R.A., Franklin, I.J., Davies, A.H. (2018). Endovenous Sealing of Superficial Veins. In: Chaar, C. (eds) Current Management of Venous Diseases . Springer, Cham. https://doi.org/10.1007/978-3-319-65226-9_11
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DOI: https://doi.org/10.1007/978-3-319-65226-9_11
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