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Effects of Reaction Knockouts on Steady States of Metabolism

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A Network-Based Approach to Cell Metabolism

Part of the book series: Springer Theses ((Springer Theses))

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Abstract

The activity and essentiality of metabolic reactions of two model organisms, Escherichia coli and Mycoplasma pneumoniae, are studied using flux balance analysis in different environments. In particular, synthetic lethal pairs correspond to combinations of active and active or inactive non-essential reactions whose simultaneous deletion causes cell death. Lethal knockouts of pairs of reactions separate in two different groups depending on whether the pair of reactions works as a backup or as a parallel use mechanism, the first corresponding to essential plasticity and the second to essential redundancy. Within this perspective, functional plasticity and redundancy are essential mechanisms underlying the ability to survive of metabolic networks.

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Authors and Affiliations

  1. Department of Materials Science and Physical Chemistry, University of Barcelona, Barcelona, Spain

    Oriol Güell

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  1. Oriol Güell
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Correspondence to Oriol Güell .

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Güell, O. (2017). Effects of Reaction Knockouts on Steady States of Metabolism. In: A Network-Based Approach to Cell Metabolism. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-64000-6_4

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