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Obesity and Endometrial Cancer: Mouse Models for Preclinical Prevention Studies

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Focus on Gynecologic Malignancies

Part of the book series: Energy Balance and Cancer ((EBAC,volume 13))

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Abstract

Endometrial cancer risk is more strongly associated with obesity than any other cancer type and it is estimated that well over half of endometrial cancer cases in the US are attributable to being overweight and obese. The evaluation of new therapeutic regimens for the prevention and treatment of human endometrial cancer patients is dependent on the development of relevant preclinical models. This chapter will examine the animal models available for endometrial cancer studies in the lab, with a focus on mouse models. Mice and other rodents represent the front line for early preclinical studies in cancer research. We will discuss specific mouse models of endometrial cancer and will further present techniques that can be used to study the role of diet, obesity, and exercise on the normal endometrium and on the pathogenesis of endometrial cancer in the lab.

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Authors and Affiliations

  1. Department of Gynecologic Oncology and Reproductive Medicine, UT MD Anderson Cancer Center, Unit 1362, P.O. Box 301439, Houston, TX, 77230-1439, USA

    Rosemarie E. Schmandt Ph.D.

  2. Unit 63, Department of Veterinary Medicine and Surgery, UT MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA

    Katherine A. Naff D.V.M

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  1. Rosemarie E. Schmandt Ph.D.
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  2. Katherine A. Naff D.V.M
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Correspondence to Rosemarie E. Schmandt Ph.D. .

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  1. Center for Science, Health and Society, Case Western Reserve University, Cleveland, Ohio, USA

    Nathan A. Berger

  2. Department of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas, USA

    Ann H. Klopp

  3. Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center, Houston, Texas, USA

    Karen H. Lu

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Schmandt, R.E., Naff, K.A. (2018). Obesity and Endometrial Cancer: Mouse Models for Preclinical Prevention Studies. In: Berger, N., Klopp, A., Lu, K. (eds) Focus on Gynecologic Malignancies. Energy Balance and Cancer, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-319-63483-8_8

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