Abstract
Endoscopic ultrasound-guided celiac plexus block and celiac plexus neurolysis are two techniques used to control pain associated with chronic pancreatitis and pancreatic cancer, respectively. These procedures are safe, have few absolute contraindications, and are relatively well tolerated. Celiac plexus block and celiac plexus neurolysis use bupivacaine followed by triamcinolone or ethyl alcohol, respectively. On average, the long-term effect of celiac plexus block is 3 months, and repeat blocks can be administered. Direct celiac plexus ganglia neurolysis is gaining acceptance in clinical practice, and further research is needed to evaluate the effectiveness of this technique.
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References
Ventafridda GV, Caraceni AT, Sbanotto AM, Barletta L, De Conno F. Pain treatment in cancer of the pancreas. Eur J Surg Oncol. 1990;16(1):1–6. Epub 1990/02/01
Lankisch PG. Natural course of chronic pancreatitis. Pancreatology. 2001;1(1):3–14. Epub 2002/07/18
Yan BM, Myers RP. Neurolytic celiac plexus block for pain control in unresectable pancreatic cancer. Am J Gastroenterol. 2007;102(2):430–8. Epub 2006/11/15
Wang PJ, Shang MY, Qian Z, Shao CW, Wang JH, Zhao XH. CT-guided percutaneous neurolytic celiac plexus block technique. Abdom Imaging. 2006;31(6):710–8. Epub 2006/12/08
Carroll I. Celiac plexus block for visceral pain. Curr Pain Headache Rep. 2006;10(1):20–5. Epub 2006/02/28
Hoffman BJ. EUS-guided celiac plexus block/neurolysis. Gastrointest Endosc. 2002;56(4 Suppl):S26–8. Epub 2002/09/26
Ventafridda V, Tamburini M, Caraceni A, De Conno F, Naldi F. A validation study of the WHO method for cancer pain relief. Cancer. 1987;59(4):850–6. Epub 1987/02/15
Kappis M. Erfahrungen mit local anasthesie bie bauchoperationen. Vehr Dtsch Gesellsch Chir. 1914;
Levy MJ, Wiersema MJ. EUS-guided celiac plexus neurolysis and celiac plexus block. Gastrointest Endosc. 2003;57(7):923–30. Epub 2003/05/31
Gress F, Schmitt C, Sherman S, Ikenberry S, Lehman G. A prospective randomized comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain. Am J Gastroenterol. 1999;94(4):900–5. Epub 1999/04/14
Ischia S, Ischia A, Polati E, Finco G. Three posterior percutaneous celiac plexus block techniques. A prospective, randomized study in 61 patients with pancreatic cancer pain. Anesthesiology. 1992;76(4):534–40. Epub 1992/04/01
Levy MJ, Topazian MD, Wiersema MJ, Clain JE, Rajan E, Wang KK, et al. Initial evaluation of the efficacy and safety of endoscopic ultrasound-guided direct ganglia neurolysis and block. Am J Gastroenterol. 2008;103(1):98–103. Epub 2007/11/01
Ward EM, Rorie DK, Nauss LA, Bahn RC. The celiac ganglia in man: normal anatomic variations. Anesth Analg. 1979;58(6):461–5. Epub 1979/11/01
Brown DL, Moore DC. The use of neurolytic celiac plexus block for pancreatic cancer: anatomy and technique. J Pain Symptom Manag. 1988;3(4):206–9. Epub 1988/01/01
Levy M, Rajan E, Keeney G, Fletcher JG, Topazian M. Neural ganglia visualized by endoscopic ultrasound. Am J Gastroenterol. 2006;101(8):1787–91. Epub 2006/06/20
Soweid AM, Azar C. Endoscopic ultrasound-guided celiac plexus neurolysis. World J Gastrointest Endosc. 2010;2(6):228–31. Epub 2010/12/17
McGreevy K, Hurley RW, Erdek MA, Aner MM, Li S, Cohen SP. The effectiveness of repeat celiac plexus neurolysis for pancreatic cancer: a pilot study. Pain Practice. 2013;13(2):89–95. Epub 2012/05/10
O'Toole TM, Schmulewitz N. Complication rates of EUS-guided celiac plexus blockade and neurolysis: results of a large case series. Endoscopy. 2009;41(7):593–7. Epub 2009/07/10
Wiersema MJ, Wiersema LM. Endosonography-guided celiac plexus neurolysis. Gastrointest Endosc. 1996;44(6):656–62. Epub 1996/12/01
LeBlanc JK, Al-Haddad M, McHenry L, Sherman S, Juan M, McGreevy K, et al. A prospective, randomized study of EUS-guided celiac plexus neurolysis for pancreatic cancer: one injection or two? Gastrointest Endosc. 2011;74(6):1300–7. Epub 2011/10/18
Pusceddu C, Mameli S, Pili A, Podda G. [Percutaneous neurolysis of the celiac plexus under CT guidance in the invasive treatment of visceral pain caused by cancer]. Neurolisi percutanea del plesso celiaco sotto guida TC nel trattamento invasivo del dolore viscerale da cancro. Tumori. 2003;89(4 Suppl):286–91. Epub 2003/08/09
Vranken JH, Zuurmond WW, Van Kemenade FJ, Dzoljic M. Neurohistopathologic findings after a neurolytic celiac plexus block with alcohol in patients with pancreatic cancer pain. Acta Anaesthesiol Scand. 2002;46(7):827–30. Epub 2002/07/26
Ascunce G, Ribeiro A, Reis I, Rocha-Lima C, Sleeman D, Merchan J, et al. EUS visualization and direct celiac ganglia neurolysis predicts better pain relief in patients with pancreatic malignancy (with video). Gastrointest Endosc. 2011;73(2):267–74. Epub 2011/02/08
Davies DD. Incidence of major complications of neurolytic coeliac plexus block. J R Soc Med. 1993;86(5):264–6. Epub 1993/05/01
Eisenberg E, Carr DB, Chalmers TC. Neurolytic celiac plexus block for treatment of cancer pain: a meta-analysis. Anesth Analg. 1995;80(2):290–5. Epub 1995/02/01
Pello S, Miller A, Ku T, Wang D. Hemorrhagic gastritis and duodenitis following celiac plexus neurolysis. Pain Physician. 2009;12(6):1001–3. Epub 2009/11/26
Gress F, Schmitt C, Sherman S, Ciaccia D, Ikenberry S, Lehman G. Endoscopic ultrasound-guided celiac plexus block for managing abdominal pain associated with chronic pancreatitis: a prospective single center experience. Am J Gastroenterol. 2001;96(2):409–16. Epub 2001/03/10
Sayed I, Elias M. Acute chemical pericarditis following celiac plexus block--a case report. Middle East J Anaesthesiol. 1997;14(3):201–6. Epub 1998/09/30
Shin SK, Kweon TD, Ha SH, Yoon KB. Ejaculatory failure after unilateral neurolytic celiac plexus block. Korean J Pain. 2010;23(4):274–7. Epub 2011/01/11
Lalueza A, Lopez-Medrano F, del Palacio A, Alhambra A, Alvarez E, Ramos A, et al. Cladosporium macrocarpum brain abscess after endoscopic ultrasound-guided celiac plexus block. Endoscopy. 2011;43 Suppl 2 UCTN:E9–10. Epub 2011/01/29.
Mercadante S, Nicosia F. Celiac plexus block: a reappraisal. Reg Anesth Pain Med. 1998;23(1):37–48. Epub 1998/04/29
Loeve US, Mortensen MB. Lethal necrosis and perforation of the stomach and the aorta after multiple EUS-guided celiac plexus neurolysis procedures in a patient with chronic pancreatitis. Gastrointest Endosc. 2013;77(1):151–2. Epub 2012/05/26
Patt RB, Reddy S. Spinal neurolysis for cancer pain: indications and recent results. Ann Acad Med Singap. 1994;23(2):216–20. Epub 1994/03/01
Gress F. Endoscopic ultrasound-guided celiac plexus neurolysis. Gastroenterol Hepatol. 2007;3(4):279–81. Epub 2007/04/01
Noble M, Gress FG. Techniques and results of neurolysis for chronic pancreatitis and pancreatic cancer pain. Curr Gastroenterol Rep. 2006;8(2):99–103. Epub 2006/03/15
Lillemoe KD, Cameron JL, Kaufman HS, Yeo CJ, Pitt HA, Sauter PK. Chemical splanchnicectomy in patients with unresectable pancreatic cancer. A prospective randomized trial. Ann Surg. 1993;217(5):447–55. discussion 56–7. Epub 1993/05/01
Fujii L, Clain JE, Morris JM, Levy MJ. Anterior spinal cord infarction with permanent paralysis following endoscopic ultrasound celiac plexus neurolysis. Endoscopy. 2012;44 Suppl 2 UCTN:E265–6. Epub 2012/07/21.
Hardy PA, Wells JC. Coeliac plexus block and cephalic spread of injectate. Ann R Coll Surg Engl. 1989;71(1):48–9. Epub 1989/01/01
Appalaneni V, et al. EUS-guided celiac plexus neurolysis vs. block: assessing interference with pancreatic surgery and adhesions in a pig survival model. GIE. 2008;69(2):233–4.
Johnson CD, Berry DP, Harris S, Pickering RM, Davis C, George S, et al. An open randomized comparison of clinical effectiveness of protocol-driven opioid analgesia, celiac plexus block or thoracoscopic splanchnicectomy for pain management in patients with pancreatic and other abdominal malignancies. Pancreatology. 2009;9(6):755–63. Epub 2010/01/22
Muscatiello N, Panella C, Pietrini L, Tonti P, Ierardi E. Complication of endoscopic ultrasound-guided celiac plexus neurolysis. Endoscopy. 2006;38(8):858. Epub 2006/09/27
Leblanc JK, Rawl S, Juan M, Johnson C, Kroenke K, McHenry L, et al. Endoscopic ultrasound-guided celiac plexus neurolysis in pancreatic cancer: a prospective pilot study of safety using 10 mL versus 20 mL alcohol. Diagnos Therap Endosc. 2013;2013:327036. Epub 2013/02/01
Sahai AV, Lemelin V, Lam E, Paquin SC. Central vs. bilateral endoscopic ultrasound-guided celiac plexus block or neurolysis: a comparative study of short-term effectiveness. Am J Gastroenterol. 2009;104(2):326–9. Epub 2009/01/29
Puli SR, Reddy JB, Bechtold ML, Antillon MR, Brugge WR. EUS-guided celiac plexus neurolysis for pain due to chronic pancreatitis or pancreatic cancer pain: a meta-analysis and systematic review. Dig Dis Sci. 2009;54(11):2330–7. Epub 2009/01/13
LeBlanc JK, DeWitt J, Johnson C, Okumu W, McGreevy K, Symms M, et al. A prospective randomized trial of 1 versus 2 injections during EUS-guided celiac plexus block for chronic pancreatitis pain. Gastrointest Endosc. 2009;69(4):835–42. Epub 2009/01/13
Sey MS, Schmaltz L, Al-Haddad MA, DeWitt JM, Calley CS, Juan M, et al. Effectiveness and safety of serial endoscopic ultrasound-guided celiac plexus block for chronic pancreatitis. Endosc Intern Open. 2015;3(1):E56–9. Epub 2015/07/03
Wyse JM, Carone M, Paquin SC, Usatii M, Sahai AV. Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer. J Clin Oncol. 2011;29(26):3541–6. Epub 2011/08/17
Doi S, Yasuda I, Kawakami H, Hayashi T, Hisai H, Irisawa A, et al. Endoscopic ultrasound-guided celiac ganglia neurolysis vs. celiac plexus neurolysis: a randomized multicenter trial. Endoscopy. 2013;45(5):362–9. Epub 2013/04/26
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Sachdev, A.H., Khan, A.S., Gress, F.G. (2018). Endoscopic Ultrasound-Guided Celiac Plexus Block and Celiac Plexus Neurolysis. In: Sridhar, S., Wu, G. (eds) Diagnostic and Therapeutic Procedures in Gastroenterology. Clinical Gastroenterology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-62993-3_40
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DOI: https://doi.org/10.1007/978-3-319-62993-3_40
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