Abstract
The goal of radiation therapy treatment is to deliver the therapeutic dose to target volumes while reduce the radiation exposure to the adjacent normal structures. In the past, a large three-dimensional planning margin was utilized to account for geometric and setup uncertainties, which resulted in unnecessary radiation doses to the surrounding normal tissues. Since the late 1990s, intensity-modulated radiation therapy (IMRT), which delivers highly conformal dose distributions to the target, has been widely adopted as standard treatment for treatment sites such as the head and neck, prostate, etc. (Butler et al. 1999; Manning et al. 2001; Zelefsky et al. 2000; De Meerleer et al. 2000). IMRT enables a more precise conformal radiation dose distribution to the target area without increasing radiation doses to the normal tissue. To translate the advantages of IMRT into better tumor control and reduction of treatment-related toxicity, more accurate and reproducible patient setup is crucial (Qi et al. 2013a).
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Qi, X.S. (2017). Image-Guided Radiation Therapy. In: Maqbool, M. (eds) An Introduction to Medical Physics. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-61540-0_5
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