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Radiologically Isolated Syndrome

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Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics

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Abstract

The incidental finding of magnetic resonance imaging changes suggestive of multiple sclerosis in individuals with no clinical symptoms of multiple sclerosis has been termed the radiologically isolated syndrome (RIS). RIS in adults carries a 30% risk of a first clinical attack within 5 years. Here, we discuss the features of pediatric RIS and propose an investigational and follow-up algorithm.

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Notes

  1. 1.

    Barkhof Criteria for DIS: (1) at least nine T2 hyperintense lesions or one gadolinium-enhancing lesion, (2) at least three periventricular lesions, (3) at least one infratentorial lesion, (4) at least one juxtacortical lesion [6].

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Author information

Authors and Affiliations

  1. Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA

    Katherine DeStefano M.D., M.S.

  2. Yale University School of Medicine, Yale New Haven Hospital, 333 Cedar Street, LMP 3088, New Haven, CT, 06510, USA

    Naila Makhani M.D., M.P.H.

Authors
  1. Katherine DeStefano M.D., M.S.
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  2. Naila Makhani M.D., M.P.H.
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Corresponding author

Correspondence to Katherine DeStefano M.D., M.S. .

Editor information

Editors and Affiliations

  1. Clinical Neurology and Pediatrics, Regional Pediatric MS Clinic at UCSF, University of California San Francisco, San Francisco, California, USA

    Emmanuelle Waubant

  2. Division of Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, USA

    Timothy E. Lotze

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DeStefano, K., Makhani, N. (2017). Radiologically Isolated Syndrome. In: Waubant, E., Lotze, T. (eds) Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics. Springer, Cham. https://doi.org/10.1007/978-3-319-61407-6_8

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  • DOI: https://doi.org/10.1007/978-3-319-61407-6_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-61405-2

  • Online ISBN: 978-3-319-61407-6

  • eBook Packages: MedicineMedicine (R0)

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