Abstract
Psychiatric manifestations of neuromyelitis optica spectrum disorder (NMOSD) are uncommon and may not immediately raise consideration for this diagnosis. The 2015 revision of the NMOSD criteria has expanded on the classic findings of optic neuritis plus transverse myelitis, thus helping the clinician consider this diagnosis with more atypical presentations. We present the case of a child with inflammatory CNS lesions plus psychiatric symptoms, whose initial aquaporin-4 antibody (AQP-4 Ab) test was negative. However, 5 years after the onset of her symptoms, she was retested and had positive serum AQP-4 Ab, confirming the diagnosis of NMOSD. This chapter will consider the NMOSD in association with psychiatric manifestations and its possible relationship with other antibody-mediated diseases.
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Lotze, T.E., McQuade, E.A. (2017). Neuromyelitis Optica Spectrum Disorder with Neuropsychiatric Presentation. In: Waubant, E., Lotze, T. (eds) Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics. Springer, Cham. https://doi.org/10.1007/978-3-319-61407-6_6
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DOI: https://doi.org/10.1007/978-3-319-61407-6_6
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