Abstract
Pediatric-onset multiple sclerosis (MS) typically presents in the teenage years but has been diagnosed in children as young as 2 years old. Current recommendations for clinical diagnosis advise to exclude the use of a lower age limit, thereby avoiding delay in treatment simply because an affected individual is considered too young. Children under the age of 10 years are most notably different when compared to adult-onset MS, making the care for these patients challenging. We present a case of pediatric-onset MS in a 3-year-old girl. Challenges in diagnosis, management, and treatment are explored, while differences in regard to acute disseminated encephalomyelitis and neuromyelitis optica presenting at this age are discussed.
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References
Krupp LB, Tardieu M, Amato MP, Banwell B, Chitnis T, Dale RC, et al. International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions. Multiple sclerosis. 2013;19(10):1261–7.
Banwell B, Ghezzi A, Bar-Or A, Mikaeloff Y, Tardieu M. Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directions. Lancet Neurol. 2007;6(10):887–902.
Alper G. Acute disseminated encephalomyelitis. J Child Neurol. 2012;27(11):1408–25.
Chabas D, Castillo-Trivino T, Mowry EM, Strober JB, Glenn OA, Waubant E. Vanishing MS T2-bright lesions before puberty: a distinct MRI phenotype? Neurology. 2008;71(14):1090–3.
Chabas D, Ness J, Belman A, Yeh EA, Kuntz N, Gorman MP, et al. Younger children with MS have a distinct CSF inflammatory profile at disease onset. Neurology. 2010;74(5):399–405.
Yeh EA, Weinstock-Guttman B. The management of pediatric multiple sclerosis. J Child Neurol. 2012;27(11):1384–93.
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Tang, Y.D., Bhise, V.V. (2017). Multiple Sclerosis in the Extremely Young. In: Waubant, E., Lotze, T. (eds) Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics. Springer, Cham. https://doi.org/10.1007/978-3-319-61407-6_4
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DOI: https://doi.org/10.1007/978-3-319-61407-6_4
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