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References

  1. Waring GO III, Rodrigues MM. Patterns of pathologic response in the cornea. Surv Opthalmol. 1987;31(4):262–6.

    Article  Google Scholar 

  2. Lam DS, Leung AT, Wu JT, Fan DS, Cheng AC, Wang Z. Culture-negative ulcerative keratitis after laser in situ keratomileusis. J Cataract Refract Surg. 1999;25(7):1004–8.

    Article  CAS  PubMed  Google Scholar 

  3. Vivino FB, Minerva P, Huang CH, Orlin SE. Corneal melt as the initial presentation of primary Sjogren’s syndrome. J Rheumatol. 2001;28(2):379–82.

    CAS  PubMed  Google Scholar 

  4. Paroli MP, Pinca M, Speranza S, Marino M, Pivetti-Pezzi P. Paracentral corneal melting in a patient with Vogt-Koyanagi-Harada’s syndrome, psoriasis, and Hashimoto’s thyroiditis. Ocul Immunol Inflamm. 2003;11(4):309–13.

    Article  PubMed  Google Scholar 

  5. Su WY, Chang SW, Huang SF. Amniotic membrane transplantation for corneal perforation related to vitamin A deficiency. Ophthalmic Surg Lasers Imaging. 2003;34(2):140–4.

    PubMed  Google Scholar 

  6. Azar G, Doan S, Cochereau I, Gabison EE. Management of post-LASIK recurrent epithelial ingrowth with flap melting using annular amniotic membrane graft. J Cataract Refract Surg. 2010;36(12):2207–8.

    Article  PubMed  Google Scholar 

  7. Beele H, Claerhout I, Kestelyn P, Dierckxens L, Naeyaert JM, De Laey JJ. Bilateral corneal melting in a patient with paraneoplastic pemphigus. Dermatology. 2001;202(2):147–50.

    Article  CAS  PubMed  Google Scholar 

  8. Nishida T, Nakamura M, Konma T, Ofuji K, Nagano K, Tanaka T, Enoki M, Reid TW, Brown SM, Murphy CJ, Manis MJ. Neurotrophic keratopathy—studies on substance P and the clinical significance of corneal sensation. Nippon Ganka Gakkai Zasshi. 1997;101(12):948–74.

    CAS  PubMed  Google Scholar 

  9. Alio JL, Artola A, Belda JI, Perez Santonja JJ, Muñoz G, Javaloy J, Rodríguez-Prats JL, Galal A. LASIK in patients with rheumatic diseases: a pilot study. Ophthalmology. 2005;112(11):1948–54.

    Article  PubMed  Google Scholar 

  10. Smith RJ, Maloney RK. Laser in situ keratomileusis in patients with autoimmune disease. J Cataract Refract Surg. 2006;32(8):1292–5.

    Article  PubMed  Google Scholar 

  11. Kohnen T. Excimer laser refractive surgery in autoimmune disease. From the Editor. J Cataract Refract Surg. 2006;32(8):1241.

    Article  PubMed  Google Scholar 

  12. Cobo-Soriano R, Beltran J, Baviera J. LASIK outcomes in patients with underlying systemic contraindications: a preliminary study. Ophthalmology. 2006;113(7):1118.e1–8.

    Article  Google Scholar 

  13. Ly Y, Li HY. Analysis of clinical characteristics and risk factors of corneal melting after laser in situ keratomileusis. Zhonghua Yan Ke Za Zhi. 2005;41(4):330–4.

    Google Scholar 

  14. Kymionis G, Ide T, Yoo S. Flap amputation with phototherapeutic keratectomy (PTK) and adjuvant mitomycin C for severe post-LASIK epithelial ingrowth. Eur J Ophthalmol. 2009;19(2):301–3.

    PubMed  Google Scholar 

  15. Kymionis GD, Kankariya VP, Kontadakis GA. Combined treatment with flap amputation, phototherapeutic keratectomy, and collagen crosslinking in severe intractable post-LASIK atypical mycobacterial infection with corneal melt. J Cataract Refract Surg. 2012;38(4):713–5.

    Article  PubMed  Google Scholar 

  16. Castillo A, Diaz-Valle D, Gutierrez AR, Toledano N, Romero F. Peripheral melt of flap after laser in situ keratomileusis. J Refract Surg. 1998;14(1):61–3.

    Google Scholar 

  17. Lam DS, Leung AT, Wu JT, Cheng AC, Fan DS, Rao SK, Talamo JH, Barraquer C. Management of severe flap wrinkling or dislodgment after laser in situ keratomileusis. J Cataract Refract Surg. 1999;25(11):1441–7.

    Article  CAS  PubMed  Google Scholar 

  18. Du Z, Guo H, Zheng Q. Immunohistochemical and clinical studies on sub-corneal flap epithelial implantation accompanied by flap melting after excimer laser in situ keratomileusis. Zhonghua Yan Ke Za Zhi. 2001;37(2):84–6.

    CAS  PubMed  Google Scholar 

  19. De Rojas Silva MV, Diez Feijo E, Rodríguez Ares MT, Sánchez-Salorio M. Confocal microscopy of stage 4 diffuse lamellar keratitis with spontaneous resolution. J Refract Surg. 2004;20(4):391–6.

    PubMed  Google Scholar 

  20. Lu KL, Wee WR, Sakamoto T, McDonnell PJ. Comparison of in vitro antiproliferative effects of steroids and nonsteroidal antiinflammatory drugs on human keratocytes. Cornea. 1996;15:185–90.

    Article  CAS  PubMed  Google Scholar 

  21. Nguyen KD, Lee DA. Effects of steroids and nonsteroidal antiinflammatory agents on human ocular fibroblast. Invest Ophthalmol Vis Sci. 1992;33:2693–701.

    CAS  PubMed  Google Scholar 

  22. Nguyen KD, Lee DA. In vitro evaluation of antiproliferative potential of topical cyclo-oxygenase inhibitors in human Tenon’s fibroblast. Exp Eye Res. 1993;57:97–105.

    Article  CAS  PubMed  Google Scholar 

  23. Nassaralla B, Szerenyi K, Wang XW, et al. Effect of diclofenac on corneal haze after photorefractive keratectomy in rabbits. Ophthalmology. 1995;102:469–74.

    Article  CAS  PubMed  Google Scholar 

  24. Hsu JK, Johnston WT, Read RW, McDonnell PJ, Pangalinan R, Rao N, Smith RE. Histopathology of corneal melting associated with diclofenac use after refractive surgery. J Cataract Refract Surg. 2003;29:250–6.

    Article  PubMed  Google Scholar 

  25. Flach AJ. Corneal melts associated with topically applied nonsteroidal anti-inflammatory drugs. Trans Am Ophthalmol Soc. 2001;99:205–10. discussion 210–2

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Gabison EE, Chastang P, Menashi S, Mourah S, Doan S, Oster M, Mauviel A, Hoang-Xuan T. Late corneal perforation after photorefractive keratectomy associated with topical diclofenac: involvement of matrix metalloproteinases. Ophthalmology. 2003;110(8):1626–31.

    Article  PubMed  Google Scholar 

  27. Hargrave SL, Jung JC, Fini ME, Gelender H, Catre C, Guidera A, Udell I, Fisher S, Jester JV, Bowman RW, McCulley JP, Cavanagh HD. Possible role of the vitamin E solubilizer in topical diclofenac on matrix metalloproteinase expression in corneal melting: an analysis of postoperative keratolysis. Ophthalmology. 2002;109(2):343–50.

    Article  PubMed  Google Scholar 

  28. Spelsberg H, Sundmacher R. Significance of immediate affixation of a hard contact lens in the emergency treatment of severe alkali burns of the cornea (case report). Klin Monatsbl Augenhelilkd. 2005;222(11):905–9.

    Article  CAS  Google Scholar 

  29. Vote BJ, Elder MJ. Cyanoacrylate glue for corneal perforations: a description of a surgical technique and a review of the literature. Clin Experiment Ophthalmol. 2000;28(6):437–42.

    Article  CAS  PubMed  Google Scholar 

  30. Xi XH, Cao YN, Tang LS, Qin B, Jiang DY. Corneal combined amniotic membrane transplantation for early severe alkali chemical injury of the eye. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004;29(6):704–6.

    PubMed  Google Scholar 

  31. Ma DH, Wang SF, Su WY, Tsai RJ. Amniotic membrane graft for the management of scleral melting and corneal perforation in recalcitrant infectious scleral and corneoscleral ulcers. Cornea. 2002;21(3):275–83.

    Article  PubMed  Google Scholar 

  32. Soong HK, Farjo AA, Katz D, Meyer RF, Sugar A. Lamellar corneal patch grafts in the management of corneal melting. Cornea. 2000;19(2):126–34.

    Article  CAS  PubMed  Google Scholar 

  33. Su CY, Lin CP. Combined use of an amniotic membrane and tissue adhesive in treating corneal perforation: a case report. Ophthalmic Surg Lasers. 2000;31(2):151–4.

    CAS  PubMed  Google Scholar 

  34. McElvanney AM. Doxycycline in the management of pseudomonas corneal melting: two case reports and a review of the literature. Eye Contact Lens. 2003;29(4):258–61.

    Article  PubMed  Google Scholar 

  35. Dudenhoefer EJ, Nouri M, Gipson IK, Baratz KH, Tisdale AS, Dryja TP, Abad JC, Dohlman CH. Histopathology of explanted collar button keratoprostheses: a clinicopathologic correlation. Cornea. 2003;22(5):424–8.

    Article  CAS  PubMed  Google Scholar 

  36. Hicks CR, Crawford GJ. Melting after keratoprosthesis implantation: the effects of medroxyprogesterone. Cornea. 2003;22(6):497–500.

    Article  PubMed  Google Scholar 

  37. He J, Bazan NG, Bazan HE. Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist. Arch Ophthalmol. 2006;124(1):70–8.

    Article  CAS  PubMed  Google Scholar 

  38. Stulting RD, Carr JD, Thompson KP, et al. Complications of laser in situ keratomileusis for the correction of myopia. Ophthalmology. 1999;106(1):13–20.

    Article  CAS  PubMed  Google Scholar 

  39. Kamburoglu G, Ertan A. Epithelial ingrowth after femtosecond laser-assisted in situ keratomileusis. Cornea. 2008;27(10):1122–5.

    Article  PubMed  Google Scholar 

  40. Henry CR, Canto AP, Galor A, et al. Epithelial ingrowth after LASIK: clinical characteristics, risk factors, and visual outcomes in patients requiring flap lift. J Refract Surg. 2012;28(7):488–92.

    Article  PubMed  Google Scholar 

  41. Letko E, Price MO, Price FW Jr. Influence of original flap creation method on incidence of epithelial ingrowth after LASIK retreatment. J Refract Surg. 2009;25(11):1039–41.

    Article  PubMed  Google Scholar 

  42. Perez-Santonja JJ, Galal A, Cardona C, Artola A, Ruiz-Moreno JM, Alio JL. Severe corneal epithelial sloughing during laser in situ keratomileusis as a presenting sign for silent epithelial basement membrane dystrophy. J Cataract Refract Surg. 2005;31(10):1932–7.

    Article  PubMed  Google Scholar 

  43. Perez-Santonja JJ, Ayala MJ, Sakla HF, Ruiz-Moreno JM, Alio JL. Retreatment after laser in situ keratomileusis. Ophthalmology. 1999;106(1):21–8.

    Article  CAS  PubMed  Google Scholar 

  44. Alio JL, Galal A, Artola A, Ayala MJ, Merayo J. Hyperopic LASIK retreatments with the Technolas laser. J Refract Surg. 2006;22(6):596–603.

    PubMed  Google Scholar 

  45. Perez-Santonja JJ, Medrano M, Ruiz-Moreno JM, Cardona-Ausina C, Alio L. Circular flap rhexis: a refinement technique for LASIK re-treatment. Arch Soc Esp Oftalmol. 2001;76(5):303–8.

    CAS  PubMed  Google Scholar 

  46. Güell JL, Elies D, Gris O, et al. Femtosecond laser-assisted enhancements after laser in situ keratomileusis. J Cataract Refract Surg. 2011;37(11):1928–31.

    Article  PubMed  Google Scholar 

  47. Lin JM, Tsai Y, Tseng SH. Spontaneous regression of dense epithelial ingrowth after laser in situ keratomileusis. J Refract Surg. 2005;21(3):300–2.

    PubMed  Google Scholar 

  48. Rapuano CJ. Management of epithelial ingrowth after laser in situ keratomileusis on a tertiary care cornea service. Cornea. 2010;29(3):307–13.

    Article  PubMed  Google Scholar 

  49. Güell JL, Verdaguer P, Mateu-Figueras G, et al. Epithelial ingrowth after LASIK: visual and refractive results after cleaning the interface and suturing the lenticule. Cornea. 2014;33(10):1046–50.

    Article  PubMed  Google Scholar 

  50. Wilde C, Messina M, Dua HS.Management of recurrent epithelial ingrowth following laser in situ keratomileusis with mechanical debridement, alcohol, mitomycin-C, and fibrin glue. J Cataract Refract Surg. 2017;43(7):980–84.

    Google Scholar 

  51. Azar DT, Scally A, Hannush SB, Soukiasian S, Terry M. Characteristic clinical findings and visual outcomes. J Cataract Refract Surg. 2003;29(12):2358–65.

    Article  PubMed  Google Scholar 

  52. Yang B, Wang Z, Chen J. The management of epithelial ingrowth after laser in situ keratomileusis. Chin Med Sci J. 2001;16(4):241–3.

    CAS  PubMed  Google Scholar 

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Güell, J.L., Morral, M., Elies, D., Gris, O., Gaytan, J., Manero, F. (2018). Melting. In: Alio, J., Azar, D. (eds) Management of Complications in Refractive Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-60561-6_12

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