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Cord Blood Graft Thawing

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Best Practices in Processing and Storage for Hematopoietic Cell Transplantation

Abstract

About 2500 transplantations using cord blood (CB) units for hematopoietic reconstitution are performed each year in the world. Their advantages, compared to other allogeneic hematopoietic progenitor cell (HPC) sources such as peripheral blood and bone marrow, are that CB HPCs allow higher HLA mismatch, result in lower GvHD rates, and are readily available for transplantation. Since CB units are small-dose, cryopreserved, and irreplaceable products, their preparation for transplantation is relatively more complex than other HPC sources. Additionally, each cord blood bank (CBB) uses slightly different methods to collect, process, and cryopreserve CB units, increasing the complexity of their processing. In order to determine how to prepare CB units for infusion, transplant centers need to assess multiple factors including transplant program setting, patient demographics, and availability of trained laboratory staff.

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Authors and Affiliations

  1. Department of Transfusion Medicine and Celluar Therapy, New York Presbyterian Hospital - Weill Cornell Medical Center, New York, NY, USA

    Ronit Reich-Slotky Ph.D., M.Sc.

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  1. Ronit Reich-Slotky Ph.D., M.Sc.
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Correspondence to Ronit Reich-Slotky Ph.D., M.Sc. .

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Editors and Affiliations

  1. Department of Pathology & Cell Biology, Columbia University, New York, New York, USA

    Joseph Schwartz

  2. New York Blood Center, New York, New York, USA

    Beth H. Shaz

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Reich-Slotky, R. (2018). Cord Blood Graft Thawing. In: Schwartz, J., Shaz, B. (eds) Best Practices in Processing and Storage for Hematopoietic Cell Transplantation . Advances and Controversies in Hematopoietic Transplantation and Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-58949-7_11

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  • DOI: https://doi.org/10.1007/978-3-319-58949-7_11

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