Abstract
Prostate brachytherapy is a very effective radiation-based treatment for localised prostate cancer. The aim is to deliver a high therapeutic dose of radiation to the prostate while minimising radiation exposure to the surrounding organs and thus limiting toxicity. Modern imaging techniques allow precise targeting of the prostate tissue and limit exposure to normal tissue. Prostate brachytherapy delivers the radiation dose directly into the target tissue without traversing skin and other structures, unlike external beam radiotherapy (EBRT). This targeted access is achieved by a template and image-guided approach delivered percutaneously through the perineum (Fig. 10.1).
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Notes
- 1.
The Gray (symbol: Gy) is a derived unit of ionising radiation dose in the International System of Units (SI). It is defined as the absorption of one joule of radiation energy per kilogram of matter.
- 2.
EPIC = Expanded Prostate Cancer Index Composite.
- 3.
IIEF = International Index of Erectile Function questionnaire.
- 4.
The EORTC QLQ-C30/PR 25 is a questionnaire developed to assess the quality of life of prostate cancer patients that includes a specific section to investigate bowel symptoms
References
Mazeron J, Scalliet P, Van Limbergen E, Lartigau E. Radiobiology of brachytherapy and the dose-rate effect. The GEC-ESTRO handbook of brachytherapy. Brussels: ESTRO; 2002. p. 95–121.
Sylvester J, Blasko JC, Grimm P, Ragde H. Interstitial implantation techniques in prostate cancer. J Surg Oncol. 1997;66(1):65–75.
Nag S, Ciezki JP, Cormack R, et al. Intraoperative planning and evaluation of permanent prostate brachytherapy: report of the American Brachytherapy Society. Int J Radiat Oncol Biol Phys. 2001;51(5):1422–30.
Genebes C, Filleron T, Graff P, et al. Conventional versus automated implantation of loose seeds in prostate brachytherapy: analysis of dosimetric and clinical results. Int J Radiat Oncol Biol Phys. 2013;87(4):651–8.
Merrick GS, Butler WM, Dorsey AT, Lief JH, Benson ML. Seed fixity in the prostate/periprostatic region following brachytherapy. Int J Radiat Oncol Biol Phys. 2000;46(1):215–20.
Tapen EM, Blasko JC, Grimm PD, et al. Reduction of radioactive seed embolization to the lung following prostate brachytherapy. Int J Radiat Oncol Biol Phys. 1998;42(5):1063–7.
Davis BJ, Pisansky TM, Wilson TM, et al. The radial distance of extraprostatic extension of prostate carcinoma: implications for prostate brachytherapy. Cancer. 1999;85(12):2630–7.
Stock RG, Stone NN. Importance of post-implant dosimetry in permanent prostate brachytherapy. Eur Urol. 2002;41(4):434–9.
Nobes JP, Khaksar SJ, Hawkins MA, Cunningham MJ, Langley SE, Laing RW. Novel prostate brachytherapy technique: improved dosimetric and clinical outcome. Radiother Oncol. 2008;88(1):121–6.
Langley SE, Laing RW. 4D Brachytherapy, a novel real-time prostate brachytherapy technique using stranded and loose seeds. BJU Int. 2012;109(Suppl 1):1–6.
Al-Qaisieh B, Carey B, Ash D, Bottomley D. The use of linked seeds eliminates lung embolization following permanent seed implantation for prostate cancer. Int J Radiat Oncol Biol Phys. 2004;59(2):397–9.
Wallis CJ, Mahar AL, Choo R, et al. Second malignancies after radiotherapy for prostate cancer: systematic review and meta-analysis. BMJ. 2016;352:i851.
Keane FK, Chen MH, Zhang D, Moran BJ, Braccioforte MH, D'Amico AV. Androgen deprivation therapy and the risk of death from prostate cancer among men with favorable or unfavorable intermediate-risk disease. Cancer. 2015;121(16):2713–9.
Brousil P, Hussain M, Lynch M, Laing RW, Langley SE. Modified transurethral resection of the prostate (TURP) for men with moderate lower urinary tract symptoms (LUTS) before brachytherapy is safe and feasible. BJU Int. 2015;115(4):580–6.
Rodrigues G, Yao X, Loblaw DA, Brundage M, Chin JL. Low-dose rate brachytherapy for patients with low- or intermediate-risk prostate cancer: A systematic review. Can Urol Assoc J. 2013;7(11-12):463–70.
Grimm P, Billiet I, Bostwick D, et al. Comparative analysis of prostate-specific antigen free survival outcomes for patients with low, intermediate and high risk prostate cancer treatment by radical therapy. Results from the Prostate Cancer Results Study Group. BJU Int. 2012;109(Suppl 1):22–9.
Ramsay CR, Adewuyi TE, Gray J, et al. Ablative therapy for people with localised prostate cancer: a systematic review and economic evaluation. Health Technol Assess. 2015;19(49):1–490.
Morris WJ, Tyldesley S, Rodda S, et al. *ASCENDE-RT: an analysis of survial endpoints for a randomized trial comparing a low-dose-rate brachytherapy boost to a dose-escalated external beam boost for high-and intermediate-risk prostate cancer. Int J Rad Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2016.11.026.
Rodrigues G, Yao X, Loblaw DA, Brundage M, Chin JL, Genitourinary Cancer Disease Site Group. Evidence-based guideline recommendations on low-dose rate brachytherapy in patients with low- or intermediate-risk prostate cancer. Can Urol Assoc J. 2013;7(5-6):E411–6.
Crook J. Long-term oncologic outcomes of radical prostatectomy compared with brachytherapy-based approaches for intermediate- and high-risk prostate cancer. Brachytherapy. 2015;14(2):142–7.
Earley JJ, Abdelbaky AM, Cunningham MJ, Chadwick E, Langley SE, Laing RW. Correlation between prostate brachytherapy-related urethral stricture and peri-apical urethral dosimetry: a matched case-control study. Radiother Oncol. 2012;104(2):187–91.
Leapman MS, Stone NN, Mock S, Stock RG, Hall SJ. Urinary incontinence following prostate brachytherapy. Urology. 2016;95:151–7.
Keyes M, Miller S, Pickles T, et al. Late urinary side effects 10 years after low-dose-rate prostate brachytherapy: population-based results from a multiphysician practice treating with a standardized protocol and uniform dosimetric goals. Int J Radiat Oncol Biol Phys. 2014;90(3):570–8.
Snyder KM, Stock RG, Buckstein M, Stone NN. Long-term potency preservation following brachytherapy for prostate cancer. BJU Int. 2012;110(2):221–5.
Stone NN, Stock RG. Long-term urinary, sexual, and rectal morbidity in patients treated with iodine-125 prostate brachytherapy followed up for a minimum of 5 years. Urology. 2007;69(2):338–42.
Emara AM, Chadwick E, Nobes JP, Abdelbaky AM, Laing RW, Langley SE. Long-term toxicity and quality of life up to 10 years after low-dose rate brachytherapy for prostate cancer. BJU Int. 2012;109(7):994–1000.
Ferrer M, Guedea F, Suarez JF, et al. Quality of life impact of treatments for localized prostate cancer: cohort study with a 5 year follow-up. Radiother Oncol. 2013;108(2):306–13.
Malcolm JB, Fabrizio MD, Barone BB, et al. Quality of life after open or robotic prostatectomy, cryoablation or brachytherapy for localized prostate cancer. J Urol. 2010;183(5):1822–8.
Yamada Y, Rogers L, Demanes DJ, et al. American Brachytherapy Society consensus guidelines for high-dose-rate prostate brachytherapy. Brachytherapy. 2012;11(1):20–32.
Hoskin PJ, Colombo A, Henry A, et al. GEC/ESTRO recommendations on high dose rate afterloading brachytherapy for localised prostate cancer: an update. Radiother Oncol. 2013;107(3):325–32.
Demanes DJ, Ghilezan MI. High-dose-rate brachytherapy as monotherapy for prostate cancer. Brachytherapy. 2014;13(6):529–41.
Hoskin PJ, Rojas AM, Bownes PJ, Lowe GJ, Ostler PJ, Bryant L. Randomised trial of external beam radiotherapy alone or combined with high-dose-rate brachytherapy boost for localised prostate cancer. Radiother Oncol. 2012;103(2):217–22.
Langley S, Ahmed HU, Al-Qaisieh B, et al. Report of a consensus meeting on focal low dose rate brachytherapy for prostate cancer. BJU Int. 2012;109(Suppl 1):7–16.
Laing R, Franklin A, Uribe J, Horton A, Uribe-Lewis S, Langley S. Hemi-gland focal low dose rate prostate brachytherapy: An analysis of dosimetric outcomes. Radiother Oncol. 2016;121(2):310–5.
Cosset JM, Cathelineau X, Wakil G, et al. Focal brachytherapy for selected low-risk prostate cancers: a pilot study. Brachytherapy. 2013;12(4):331–7.
Henriquez I, Sancho G, Hervas A, et al. Salvage brachytherapy in prostate local recurrence after radiation therapy: predicting factors for control and toxicity. Radiat Oncol. 2014;9:102.
Gomez-Veiga F, Marino A, Alvarez L, et al. Brachytherapy for the treatment of recurrent prostate cancer after radiotherapy or radical prostatectomy. BJU Int. 2012;109(Suppl 1):17–21.
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Soares, R., Uribe-Lewis, S., Uribe, J., Langley, S. (2018). Brachytherapy for Prostate Cancer. In: Goonewardene, S., Persad, R. (eds) Surgical Procedures for Core Urology Trainees. Springer, Cham. https://doi.org/10.1007/978-3-319-57442-4_10
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