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The Role of Endoscopic Transsphenoidal Surgery in the Management of Complex Lesions Involving the Skull Base

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Transsphenoidal Surgery

Abstract

Since the repopularization of the transsphenoidal approach by Guiot and Hardy, most surgeons have adopted this technique as the primary method for the removal of pituitary adenomas. With the development of modern microinstrumentation, the use of the operating microscope, and advances in endoscopic endonasal instrumentation and navigation, the endonasal transsphenoidal approach has become the preferred method for targeting sellar and parasellar lesions. Exposure beyond the parasellar region in the sagittal and coronal planes can be achieved when the extended transsphenoidal approach is performed using a purely endoscopic endonasal approach (EEA) without a nasal speculum. With the recent advent of extended EEAs, access to a variety of skull base lesions outside of the sella and sphenoid sinus can be accomplished. In the sagittal plane, ventral pathology can be accessed from the frontal sinuses anteriorly to the odontoid process posteroinferiorly. In the coronal plane, lateral access can be achieved to remove lesions occupying the cavernous sinus, infratemporal fossa, middle fossa, and petrous apex. Various endoscopic endonasal corridors have been developed to access a desired target of the ventral skull base. The majority of these EEAs share a common initial transsphenoidal approach to the ventral skull base before branching out into their respective paths along the sagittal or coronal plane. In this chapter, the authors discuss the various endoscopic endonasal corridors that allow access to a wide variety of complex skull base lesions.

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References

  1. Hardy J. Transsphenoidal microsurgery of the normal and pathological pituitary. Clin Neurosurg. 1969;16:185–217.

    CAS  PubMed  Google Scholar 

  2. Gandhi CD, Christiano LD, Eloy JA, et al. The historical evolution of transsphenoidal surgery: facilitation by technological advances. Neurosurg Focus. 2009;27(3):E8.

    PubMed  Google Scholar 

  3. Patel SK, Husain Q, Eloy JA, et al. Norman Dott, Gerard Guiot, and Jules Hardy: key players in the resurrection and preservation of transsphenoidal surgery. Neurosurg Focus. 2012;33(2):E6.

    PubMed  Google Scholar 

  4. Hardy J. Transsphenoidal hypophysectomy. J Neurosurg. 1971;34:582–94.

    CAS  Google Scholar 

  5. Guiot G, Thibaut B. L’extirpation des adenomes hypophysaries par voie trans-sphenoidale. Neurochirurgia (Stuttg). 1959;1:133–50.

    CAS  Google Scholar 

  6. Liu JK, Das K, Weiss MH, et al. The history and evolution of transsphenoidal surgery. J Neurosurg. 2001;95:1083–96.

    CAS  PubMed  Google Scholar 

  7. Lanzino G, Laws Jr ER. Key personalities in the development and popularization of the transsphenoidal approach to pituitary tumors: an historical overview. Neurosurg Clin N Am. 2003;14:1–10.

    PubMed  Google Scholar 

  8. Black PM, Zervas NT, Candia GL. Incidence and management of complications of transsphenoidal operation for pituitary adenomas. Neurosurgery. 1987;20:920–4.

    CAS  PubMed  Google Scholar 

  9. Ciric I, Mikhael M, Stafford T, et al. Transsphenoidal microsurgery of pituitary macroadenomas with long-term follow-up results. J Neurosurg. 1983;59:395–401.

    CAS  PubMed  Google Scholar 

  10. Jane JA, Jr., Thapar K, Kaptain GJ, et al. Pituitary surgery: transsphenoidal approach. Neurosurgery. 2002;51:435–42; discussion 442–4.

    Google Scholar 

  11. Laws ER, Jane Jr JA. Pituitary tumors – long-term outcomes and expectations. Clin Neurosurg. 2001;48:306–19.

    CAS  PubMed  Google Scholar 

  12. Liu JK, Weiss MH, Couldwell WT. Surgical approaches to pituitary tumors. Neurosurg Clin N Am. 2003;14:93–107.

    PubMed  Google Scholar 

  13. Liu JK, Christiano LD, Patel SK, et al. Surgical nuances for removal of olfactory groove meningiomas using the endoscopic endonasal transcribriform approach. Neurosurg Focus. 2011;30(5):E3.

    PubMed  Google Scholar 

  14. Liu JK, Christiano LD, Patel SK, et al. Surgical nuances for removal of retrochiasmatic craniopharyngioma via the endoscopic endonasal extended transsphenoidal transplanum transtuberculum approach. Neurosurg Focus. 2011;30(4):E14.

    PubMed  Google Scholar 

  15. Liu JK, Christiano LD, Patel SK, et al. Surgical nuances for removal of tuberculum sellae meningiomas with optic canal involvement using the endoscopic endonasal extended transsphenoidal transplanum transtuberculum approach. Neurosurg Focus. 2011;30(5):E2.

    PubMed  Google Scholar 

  16. Cavallo LM, Messina A, Gardner P, et al. Extended endoscopic endonasal approach to the pterygopalatine fossa: anatomical study and clinical considerations. Neurosurg Focus. 2005;19(1):E5.

    PubMed  Google Scholar 

  17. Cook SW, Smith Z, Kelly DF. Endonasal transsphenoidal removal of tuberculum sellae meningiomas: technical note. Neurosurgery. 2004;55:239–44; discussion 244–6.

    Google Scholar 

  18. de Divitiis E, Cappabianca P, Cavallo LM. Endoscopic transsphenoidal approach: adaptability of the procedure to different sellar lesions. Neurosurgery. 2002;51:699–705; discussion 705–7.

    Google Scholar 

  19. Liu JK, Decker D, Schaefer SD, et al. Zones of approach for craniofacial resection: minimizing facial incisions for resection of anterior cranial base and paranasal sinus tumors. Neurosurgery. 2003;53:1126–35; discussion 1135–7.

    Google Scholar 

  20. Kitano M, Taneda M. Extended transsphenoidal approach with submucosal posterior ethmoidectomy for parasellar tumors. Technical note. J Neurosurg. 2001;94:999–1004.

    CAS  PubMed  Google Scholar 

  21. Kaptain GJ, Vincent DA, Sheehan JP, et al. Transsphenoidal approaches for the extracapsular resection of midline suprasellar and anterior cranial base lesions. Neurosurgery. 2001;49:94–100; discussion 100–1.

    Google Scholar 

  22. Kouri JG, Chen MY, Watson JC, et al. Resection of suprasellar tumors by using a modified transsphenoidal approach. Report of four cases. J Neurosurg. 2000;92:1028–35.

    CAS  PubMed  Google Scholar 

  23. Mason RB, Nieman LK, Doppman JL, et al. Selective excision of adenomas originating in or extending into the pituitary stalk with preservation of pituitary function. J Neurosurg. 1997;87:343–51.

    CAS  PubMed  Google Scholar 

  24. Laws Jr ER. Transsphenoidal removal of craniopharyngioma. Pediatr Neurosurg. 1994;21(Suppl 1):57–63.

    PubMed  Google Scholar 

  25. Laws Jr ER. Transsphenoidal microsurgery in the management of craniopharyngioma. J Neurosurg. 1980;52:661–6.

    PubMed  Google Scholar 

  26. Weiss MH. Transnasal transsphenoidal approach. In: Apuzzo M, editor. Surgery of the third ventricle. Baltimore: Williams & Wilkins; 1987. p. 476–94.

    Google Scholar 

  27. Couldwell WT, Weiss MH, Rabb C, et al. Variations on the standard transsphenoidal approach to the sellar region, with emphasis on the extended approaches and parasellar approaches: surgical experience in 105 cases. Neurosurgery. 2004;55:539–47; discussion 547–50.

    Google Scholar 

  28. Couldwell WT, Weiss MH. Transnasal transsphenoidal approach. In: Apuzzo M, editor. Surgery of the third ventricle. 2nd ed. Baltimore: Williams & Wilkins; 1998. p. 553–74.

    Google Scholar 

  29. Schwartz TH, Fraser JF, Brown S, et al. Endoscopic cranial base surgery: classification of operative approaches. Neurosurgery. 2008;62:991–1002; discussion 1002–5.

    Google Scholar 

  30. Kassam A, Snyderman CH, Mintz A, et al. Expanded endonasal approach: the rostrocaudal axis. Part I. Crista Galli to the sella turcica. Neurosurg Focus. 2005;19:E3.

    PubMed  Google Scholar 

  31. Kassam A, Snyderman CH, Mintz A, et al. Expanded endonasal approach: the rostrocaudal axis. Part II. Posterior clinoids to the foramen magnum. Neurosurg Focus. 2005;19:E4.

    PubMed  Google Scholar 

  32. Kassam AB, Gardner P, Snyderman C, et al. Expanded endonasal approach: fully endoscopic, completely transnasal approach to the middle third of the clivus, petrous bone, middle cranial fossa, and infratemporal fossa. Neurosurg Focus. 2005;19:E6.

    PubMed  Google Scholar 

  33. Liu JK, Hattar E, Eloy JA. Endoscopic endonasal approach for olfactory groove meningiomas: operative technique and nuances. Neurosurg Clin N Am. 2015;26:377–88.

    PubMed  Google Scholar 

  34. Liu JK, Eloy JA. Expanded endoscopic endonasal transcribriform approach for resection of anterior skull base olfactory schwannoma. J Neurosurg. 2012;32 Suppl:E3.

    PubMed  Google Scholar 

  35. Patel AA, Friedel ME, Liu JK, et al. Endoscopic endonasal resection of extensive anterior skull base sinonasal osteoblastoma. Otolaryngol Head Neck Surg. 2012;147:594–6.

    PubMed  Google Scholar 

  36. Vazquez A, Liu JK, Eloy JA. Endoscopic endonasal surgery of the sphenoid sinus: extended approaches. Oper Tech Otolaryngol Head Neck Surg. 2014;25:174–9.

    Google Scholar 

  37. Labib MA, Prevedello DM, Fernandez-Miranda JC, et al. The medial opticocarotid recess: an anatomic study of an endoscopic “key landmark” for the ventral cranial base. Neurosurgery. 2013;72:66–76; discussion 76.

    Google Scholar 

  38. Cavallo LM, Frank G, Cappabianca P, et al. The endoscopic endonasal approach for the management of craniopharyngiomas: a series of 103 patients. J Neurosurg. 2014;121:100–13.

    PubMed  Google Scholar 

  39. Kato T, Sawamura Y, Abe H, et al. Transsphenoidal-transtuberculum sellae approach for supradiaphragmatic tumours: technical note. Acta Neurochir. 1998;140:715–8; discussion 719.

    Google Scholar 

  40. Laws Jr ER. Craniopharyngioma: transsphenoidal surgery. Curr Ther Endocrinol Metab. 1997;6:35–8.

    PubMed  Google Scholar 

  41. Maira G, Anile C, Albanese A, et al. The role of transsphenoidal surgery in the treatment of craniopharyngiomas. J Neurosurg. 2004;100:445–51.

    PubMed  Google Scholar 

  42. Maira G, Anile C, Rossi GF, et al. Surgical treatment of craniopharyngiomas: an evaluation of the transsphenoidal and pterional approaches. Neurosurgery. 1995;36:715–24.

    CAS  PubMed  Google Scholar 

  43. Eloy JA, Vazquez A, Marchiano E, et al. Variations of mucosal-sparing septectomy for endonasal approach to the craniocervical junction. Laryngoscope. 2016;126:2220–5.

    PubMed  Google Scholar 

  44. Mangussi-Gomes J, Beer-Furlan A, Balsalobre L, et al. Endoscopic endonasal management of skull base chordomas: surgical technique, nuances, and pitfalls. Otolaryngol Clin N Am. 2016;49:167–82.

    Google Scholar 

  45. Koutourousiou M, Gardner PA, Tormenti MJ, et al. Endoscopic endonasal approach for resection of cranial base chordomas: outcomes and learning curve. Neurosurgery. 2012;71:614–24; discussion 624–5.

    Google Scholar 

  46. Fraser JF, Nyquist GG, Moore N, et al. Endoscopic endonasal transclival resection of chordomas: operative technique, clinical outcome, and review of the literature. J Neurosurg. 2010;112:1061–9.

    PubMed  Google Scholar 

  47. Ditzel Filho LF, Prevedello DM, Dolci RL, et al. The endoscopic endonasal approach for removal of petroclival chondrosarcomas. Neurosurg Clin N Am. 2015;26:453–62.

    PubMed  Google Scholar 

  48. Maira G, Pallini R, Anile C, et al. Surgical treatment of clival chordomas: the transsphenoidal approach revisited. J Neurosurg. 1996;85:784–92.

    CAS  PubMed  Google Scholar 

  49. Cavallo LM, Cappabianca P, Messina A, et al. The extended endoscopic endonasal approach to the clivus and cranio-vertebral junction: anatomical study. Childs Nerv Syst. 2007;23:665–71.

    CAS  PubMed  Google Scholar 

  50. Fang CH, Friedman R, Schild SD, et al. Purely endoscopic endonasal surgery of the craniovertebral junction: a systematic review. Int Forum Allergy Rhinol. 2015;5:754–60.

    PubMed  Google Scholar 

  51. Liu JK, Patel J, Goldstein IM, et al. Endoscopic endonasal transclival transodontoid approach for ventral decompression of the craniovertebral junction: operative technique and nuances. Neurosurg Focus. 2015;38:E17.

    PubMed  Google Scholar 

  52. Aldana PR, Naseri I, La Corte E. The naso-axial line: a new method of accurately predicting the inferior limit of the endoscopic endonasal approach to the craniovertebral junction. Neurosurgery. 2012;71:ons308–14; discussion ons314.

    Google Scholar 

  53. Kasemsiri P, Solares CA, Carrau RL, et al. Endoscopic endonasal transpterygoid approaches: anatomical landmarks for planning the surgical corridor. Laryngoscope. 2013;123:811–5.

    PubMed  Google Scholar 

  54. Couldwell WT, Sabit I, Weiss MH, et al. Transmaxillary approach to the anterior cavernous sinus: a microanatomic study. Neurosurgery. 1997;40:1307–11.

    CAS  PubMed  Google Scholar 

  55. Sabit I, Schaefer SD, Couldwell WT. Modified infratemporal fossa approach via lateral transantral maxillotomy: a microsurgical model. Surg Neurol. 2002;58:21–31; discussion 31.

    Google Scholar 

  56. Kassam AB, Prevedello DM, Carrau RL, et al. Endoscopic endonasal skull base surgery: analysis of complications in the authors’ initial 800 patients. J Neurosurg. 2011;114:1544–68.

    PubMed  Google Scholar 

  57. Liu JK, Husain Q, Kanumuri V, et al. Endoscopic graduated multiangle, multicorridor resection of juvenile nasopharyngeal angiofibroma: an individualized, tailored, multicorridor skull base approach. J Neurosurg. 2016;124:1328–38.

    PubMed  Google Scholar 

  58. Jho D, Jho D, Jho H-D. Endoscopic endonasal pituitary and skull base surgery. In: Quinones-Hinojosa A, editor. Schmidek and sweet operative neurosurgical techniques. Philadelphia: Elsevier; 2012. p. 257–79.

    Google Scholar 

  59. Couldwell WT, Rosenow JM, Rovit RL, et al. Hypophysopexy technique for radiosurgical treatment of cavernous sinus pituitary adenoma. Pituitary. 2002;5:169–73.

    PubMed  Google Scholar 

  60. Liu JK, Schmidt MH, MacDonald JD, et al. Hypophysial transposition (hypophysopexy) for radiosurgical treatment of pituitary tumors involving the cavernous sinus: technical note. Neurosurg Focus. 2003;14(5):Article 11.

    Google Scholar 

  61. Liu JK, Orlandi RR, Apfelbaum RI, et al. Novel closure technique for the endonasal transsphenoidal approach. Technical note. J Neurosurg. 2004;100:161–4.

    PubMed  Google Scholar 

  62. Casiano RR, Herzallah IR, Anstead A, et al. Advanced endoscopic sinonasal dissection. In: Casiano RR, editor. Endoscopic sinonasal dissection guide. New York: Thieme Medical Publishers Inc.; 2012. p. 59–99.

    Google Scholar 

  63. Eloy JA, Patel AA, Shukla PA, et al. Early harvesting of the vascularized pedicled nasoseptal flap during endoscopic skull base surgery. Am J Otolaryngol. 2013;34:188–94.

    PubMed  Google Scholar 

  64. Eloy JA, Mady LJ, Kanumuri VV, et al. Modified subtotal-Lothrop procedure for extended frontal sinus and anterior skull-base access: a case series. Int Forum Allergy Rhinol. 2014;4:517–22.

    PubMed  Google Scholar 

  65. Eloy JA, Vazquez A, Liu JK, et al. Endoscopic approaches to the frontal sinus: modifications of the existing techniques and proposed classification. Otolaryngol Clin N Am. 2016;49(4):1007–18. In Press.

    Google Scholar 

  66. Eloy JA, Vazquez A, Mady LJ, et al. Mucosal-sparing posterior septectomy for endoscopic endonasal approach to the craniocervical junction. Am J Otolaryngol. 2015;36:342–6.

    PubMed  Google Scholar 

  67. Liu JK, O’Neill B, Orlandi RR, et al. Endoscopic-assisted craniofacial resection of esthesioneuroblastoma: minimizing facial incisions – technical note and report of 3 cases. Minim Invasive Neurosurg. 2003;46:310–5.

    CAS  PubMed  Google Scholar 

  68. Schmidt RF, Choudhry OJ, Raviv J, et al. Surgical nuances for the endoscopic endonasal transpterygoid approach to lateral sphenoid sinus encephaloceles. Neurosurg Focus. 2012;32(6):E5.

    PubMed  Google Scholar 

  69. Eloy JA, Murray KP, Friedel ME, et al. Graduated endoscopic multiangle approach for access to the infratemporal fossa: a cadaveric study with clinical correlates. Otolaryngol Head Neck Surg. 2012;147:369–78.

    PubMed  Google Scholar 

  70. Eloy JA, Kuperan AB, Choudhry OJ, et al. Efficacy of the pedicled nasoseptal flap without cerebrospinal fluid (CSF) diversion for repair of skull base defects: incidence of postoperative CSF leaks. Int Forum Allergy Rhinol. 2012;2:397–401.

    PubMed  Google Scholar 

  71. Eloy JA, Choudhry OJ, Shukla PA, et al. Nasoseptal flap repair after endoscopic transsellar versus expanded endonasal approaches: is there an increased risk of postoperative cerebrospinal fluid leak? Laryngoscope. 2012;122:1219–25.

    PubMed  Google Scholar 

  72. Eloy JA, Shukla PA, Choudhry OJ, et al. Challenges and surgical nuances in reconstruction of large planum sphenoidale tuberculum sellae defects after endoscopic endonasal resection of parasellar skull base tumors. Laryngoscope. 2013;123:1353–60.

    PubMed  Google Scholar 

  73. Eloy JA, Choudhry OJ, Christiano LD, et al. Double flap technique for reconstruction of anterior skull base defects after craniofacial tumor resection: technical note. Int Forum Allergy Rhinol. 2013;3:425–30.

    PubMed  Google Scholar 

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Liu, J.K., Spinazzi, E.F., Eloy, J.A., Couldwell, W.T. (2017). The Role of Endoscopic Transsphenoidal Surgery in the Management of Complex Lesions Involving the Skull Base. In: Laws, Jr, E.R., Cohen-Gadol, A.A., Schwartz, T.H., Sheehan, J.P. (eds) Transsphenoidal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-56691-7_17

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