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Physiologic Pigmentation

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Dermatoanthropology of Ethnic Skin and Hair

Abstract

There are a number of different patterns of pigment variation that lie within the spectrum of normal pigmentation. In general, these are typically more common and more prominent in skin of color. The most common of these will be discussed in this chapter including pigmentary demarcation lines, periorbital hyperpigmentation, acquired idiopathic pattern facial pigmentation (AIPFP), oral mucosal hyperpigmentation, palmar/plantar melanotic macules, and longitudinal physiologic melanonychia.

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References

  1. Vrieling H, Duhl DMJ, Millar SE, Miller KA, Barsh GS. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc National Academy Sci. 1994;91:5667–71.

    Article  CAS  Google Scholar 

  2. Walsh RJ. Variation in the melanin content of the skin of New Guinea natives at different ages. J Invest Dermatolo. 1964;42(3):261–5.

    Article  CAS  Google Scholar 

  3. Park JH, Lee MH. A study of skin color by melanin index according to site, gestational age, birth weight and season of birth in Korean neonates. J Korean Med Sci. 2005;20(1):105–8.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Post PW, Krauss AN, Walcman S, Auld PA. Skin reflectance of newborn infants from 25 to 44 weeks gestational age. Hum Biol. 1976;48(3):541–57.

    CAS  PubMed  Google Scholar 

  5. Zhang R, Zhu W. Coexistence of pigmentary demarcation lines types C and E in one subject. Int J Dermatol. 2011;50(7):863–5.

    Article  PubMed  Google Scholar 

  6. James WD, Carter JM, Rodman OG. Pigmentary demarcation lines: a population survey. J Am Acad Dermatol. 1987;16(3):584–90.

    Article  CAS  PubMed  Google Scholar 

  7. Kumari R, Laxmisha C, Thappa DM. Pigmentary demarcation lines associated with pregnancy. J Cosmetic Dermatolo. 2006;5(2):169–70.

    Article  Google Scholar 

  8. Chandran V, Kurien G, Mohan V. Pigmentary demarcation lines in pregnancy. Indian J Dermatol. 2016;61(1):127.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Matzumoto SH. Über eine eigentümliche Pigmentverteilung an den Voigtschen Linien. (Beitrag zur Kenntnis der Voigtschen Grenzen). Archiv für Dermatologie und Syphilis. 1913;118(1):157–64.

    Article  Google Scholar 

  10. Malakar S, Lahiri K, Banerjee U, Mondal S, Sarangi S. Periorbital melanosis is an extension of pigmentary demarcation line-F on face. Indian J Dermatol Venereol Leprol. 2007;73(5):323–5.

    Article  PubMed  Google Scholar 

  11. James WD, Meltzer MS, Guill MA, Berger TG, Rodman OG. Pigmentary demarcation lines associated with pregnancy. J Am Acad Dermatol. 1984;11(3):438–40.

    Article  CAS  PubMed  Google Scholar 

  12. Miura O. On the demarcation lines of pigmentation observed among the Japanese, on inner sides of their extremities and on anterior and posterior sides of their medial regions. Tohoku J Exp Med. 1951;54(2):135–40.

    Article  CAS  PubMed  Google Scholar 

  13. Maleville J, Taieb A. Pigmentary demarcation lines as markers of neural development. Arch Dermatol. 1997;133(11):1459.

    Article  CAS  PubMed  Google Scholar 

  14. Krivo JM. How common is pigmentary mosaicism? Arch Dermatol. 1997;133(4):527–8.

    Article  CAS  PubMed  Google Scholar 

  15. Treat J. Patterned pigmentation in children. Pediatric Clin. 2010;57(5):1121–9.

    Article  Google Scholar 

  16. Peck J, Cusack C. Futcher lines: a case report in pregnancy and literature review. Cutis. 2013;92(2):100–1.

    PubMed  Google Scholar 

  17. Bukhari IA. Effective treatment of Futcher’s lines with q-switched Alexandrite laser. J Cosmetic Dermatol. 2005;4(1):27–8.

    Article  CAS  Google Scholar 

  18. Sarkar R, Ranjan R, Garg S, Garg VK, Sonthalia S, Bansal S. Periorbital hyperpigmentation: a comprehensive review. J Clin Aesthetic Dermatol. 2016;9(1):49–55.

    Google Scholar 

  19. Verschoore M, Gupta S, Sharma VK, Ortonne J-P. Determination of melanin and haemoglobin in the skin of idiopathic cutaneous hyperchromia of the orbital region (ICHOR): a study of Indian patients. J Cutaneous Aesthetic Surg. 2012;5(3):176–82.

    Article  Google Scholar 

  20. Roh MR, Chung KR. Infraorbital dark circles: definition, causes, and treatment options. Dermatol Surg. 2009;35(8):1163–71.

    Article  CAS  PubMed  Google Scholar 

  21. Ranu H, Thng S, Goh BK, Burger A, Goh CL. Periorbital hyperpigmentation in Asians: an epidemiologic study and a proposed classification. Dermatol Surg. 2011;37(9):1297–303.

    Article  CAS  PubMed  Google Scholar 

  22. Watanabe S, Nakai K, Ohnishi T. Condition known as “dark rings under the eyes” in the Japanese population is a kind of dermal melanocytosis which can be successfully treated by Q-switched ruby laser. Dermatol Surg. 2006;32(6):785–9.

    CAS  PubMed  Google Scholar 

  23. West TB, Alster TS. Improvement of infraorbital hyperpigmentation following carbon dioxide laser resurfacing. Dermatol Surg. 1998;24(6):615–6.

    Article  CAS  PubMed  Google Scholar 

  24. Cymbalista NC. Oliveira ZNPd. Treatment of idiopathic cutaneous hyperchromia of the orbital region (ICHOR) with intense pulsed light. Dermatol Surg. 2006;32(6):773–83.

    CAS  PubMed  Google Scholar 

  25. Sarkar R. Idiopathic cutaneous hyperchromia at the orbital region or periorbital hyperpigmentation. JCutaneous Aesthetic Sur. 2012;5(3):183–4.

    Google Scholar 

  26. Goodman RM, Belcher RW. Periorbital hyperpigmentation: an overlooked genetic disorder of pigmentation. Arch Dermatol. 1969;100(2):169–74.

    Article  CAS  PubMed  Google Scholar 

  27. Ranjan R, Sarkar R, Garg VK, Gupta T. A comparative study of two modalities, 4% hydroquinone versus 30% salicylic acid in periorbital hyperpigmentation and assessment of quality of life before and after treatment. Indian J Dermatol. 2016;61(4):413–7.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Bosniak S, Sadick NS, Cantisano-Zilkha M, Glavas IP, Roy D. The hyaluronic acid push technique for the nasojugal groove. Dermatol Surg. 2008;34(1):127–31.

    Article  CAS  PubMed  Google Scholar 

  29. Roh MR, Kim TK, Chung KY. Treatment of infraorbital dark circles by autologous fat transplantation: a pilot study. Br J Dermatol. 2009;160(5):1022–5.

    Article  CAS  PubMed  Google Scholar 

  30. Ohshima H, Mizukoshi K, Oyobikawa M, Matsumoto K, Takiwaki H, Kanto H, et al. Effects of vitamin C on dark circles of the lower eyelids: quantitative evaluation using image analysis and echogram. Skin Res Technol. 2009;15(2):214–7.

    Article  PubMed  Google Scholar 

  31. Lowe NJ, Wieder JM, Shorr N, Boxrud C, Saucer D, Chalet M. Infraorbital pigmented skin. Preliminary observations of laser therapy. Dermatol Surg. 1995;21(9):767–70.

    Article  CAS  PubMed  Google Scholar 

  32. Manuskiatti W, Fitzpatrick RE, Goldman MP. Treatment of facial skin using combinations of CO2 Q-switched alexandrite, flashlamp-pumped pulsed dye, and Er: YAG lasers in the same treatment session. Dermatol Sur. 2000;26(2):114–20.

    Article  CAS  Google Scholar 

  33. Cisneros JL. RIo R, Palou J. The Q-switched neodymium (Nd):YAG laser with quadruple frequency. Clinical histological evaluation of facial resurfacing using different wavelengths. Dermatol Surg. 1998;24(3):345–50.

    Article  CAS  PubMed  Google Scholar 

  34. Sarma N, Chakraborty S, Bhattacharya SR. Acquired, idiopathic, patterned facial pigmentation (AIPFP) including periorbital pigmentation and pigmentary demarcation lines on face follows the lines of Blaschko on face. Indian J Dermatol. 2014;59(1):41–8.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Eisen D. Disorders of pigmentation in the oral cavity. Clin Dermatol. 2000;18(5):579–87.

    Article  CAS  PubMed  Google Scholar 

  36. Muller S. Melanin-associated pigmented lesions of the oral mucosa: presentation, differential diagnosis, and treatment. Dermatol Ther. 2010;23(3):220–9.

    Article  PubMed  Google Scholar 

  37. Chandra S, Keluskar V, Bagewadi A, Sah K. Extensive physiologic melanin pigmentation on the tongue: an unusual clinical presentation. Contemp Clin Dent. 2010;1(3):204–6.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Buchner A, Hansen LS. Amalgam pigmentation (amalgam tattoo) of the oral mucosa. A clinicopathologic study of 268 cases. Oral Sur Oral Med Oral Pathol. 1980;49(2):139–47.

    Article  CAS  Google Scholar 

  39. Hedin CA, Axell T. Oral melanin pigmentation in 467 Thai and Malaysian people with special emphasis on smoker’s melanosis. J Oral Pathol Med. 1991;20(1):8–12.

    Article  CAS  PubMed  Google Scholar 

  40. Fry L, Almeyda JR. The incidence of buccal pigmentation in caucasoids and negroids in Britain. Br J Dermatol. 1968;80(4):244–7.

    Article  CAS  PubMed  Google Scholar 

  41. Lenane P, Powell FC. Oral pigmentation. J Eur Acad Dermatol Venereol. 2000;14(6):448–65.

    Article  CAS  PubMed  Google Scholar 

  42. Amir E, Gorsky M, Buchner A, Sarnat H, Gat H. Physiologic pigmentation of the oral mucosa in Israeli children. Oral Sur Oral Med Oral Pathol. 1991;71(3):396–8.

    Article  CAS  Google Scholar 

  43. Buchner A, Merrell PW, Carpenter WM. Relative frequency of solitary melanocytic lesions of the oral mucosa. J Oral Pathol Med. 2004;33(9):550–7.

    Article  CAS  PubMed  Google Scholar 

  44. Kaugars GE, Heise AP, Riley WT, Abbey LM, Svirsky JA. Oral melanotic macules. A review of 353 cases. Oral Sur Oral Med Oral Pathol. 1993;76(1):59–61.

    Article  CAS  Google Scholar 

  45. Meleti M, Vescovi P, Mooi WJ, van der Waal I. Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management. Oral Sur Oral Med Oral Pathol Oral Radiol Endodontol. 2008;105(5):606–16.

    Article  Google Scholar 

  46. Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol. 2000;36(2):152–69.

    Article  CAS  PubMed  Google Scholar 

  47. Lin YH, Tu YK, Lu CT, Chung WC, Huang CF, Huang MS, et al. Systematic review of treatment modalities for gingival depigmentation: a random-effects poisson regression analysis. J Esthetic Restorative Dent. 2014;26(3):162–78.

    Article  Google Scholar 

  48. Talebi M, Farmanbar N, Abolfazli S, Shirazi AS. Management of physiological hyperpigmentation of oral mucosa by cryosurgical treatment: a case report. J Dental Res Dental Clin Dental Prospects. 2012;6(4):148–51.

    Google Scholar 

  49. Lenane P, Keane CO, Connell BO, Loughlin SO, Powell FC. Genital melanotic macules: clinical, histological, immunohistochemical, and ultrastructural features. J Am Acad Dermatol. 2000;42(4):640–4.

    Article  CAS  PubMed  Google Scholar 

  50. Blossom J, Altmayer S, Jones DM, Slominski A, Carlson JA. Volar melanotic macules in a gardener: a case report and review of the literature. Am J Dermatopathol. 2008;30(6):612–9.

    Article  PubMed  Google Scholar 

  51. Kiyohara T, Kumakiri M, Kouraba S, Lao LM, Sawai T. Volar melanotic macules in a Japanese man with histopathological postinflammatory pigmentation: the volar counterpart of mucosal melanotic macules. J Cutan Pathol. 2001;28(6):303–6.

    Article  CAS  PubMed  Google Scholar 

  52. Chapel TA, Taylor RM, Pinkus H. Volar melanotic macules. Int J Dermatol. 1979;18(3):222–5.

    Article  CAS  PubMed  Google Scholar 

  53. Cho KH, Chung JH, Lee AY, Lee YS, Kim NK, Kim CW. Pigmented macules in patients treated with systemic 5-fluorouracil. J Dermatol. 1988;15(4):342–6.

    Article  CAS  PubMed  Google Scholar 

  54. Dominguez-Cherit J, Roldan-Marin R, Pichardo-Velazquez P, Valente C, Fonte-Avalos V, Vega-Memije ME, et al. Melanonychia, melanocytic hyperplasia, and nail melanoma in a Hispanic population. J Am Acad Dermatol. 2008;59(5):785–91.

    Article  PubMed  Google Scholar 

  55. Ronger S, Touzet S, Ligeron C, Balme B, Viallard AM, Barrut D, et al. Dermoscopic examination of nail pigmentation. Arch Dermatol. 2002;138(10):1327–33.

    Article  PubMed  Google Scholar 

  56. Braun RP, Baran R, Gal FAL, Dalle S, Ronger S, Pandolfi R, et al. Diagnosis and management of nail pigmentations. J Am Acad Dermatol. 2007;56(5):835–47.

    Article  PubMed  Google Scholar 

  57. Molina D, Sanchez JL. Pigmented longitudinal bands of the nail. A clinicopathologic study. Am J Dermatopathol. 1995;17(6):539–41.

    Article  CAS  PubMed  Google Scholar 

  58. Haneke E, Baran R. Longitudinal melanonychia. Dermatol Surg. 2001;27(6):580–4.

    Article  CAS  PubMed  Google Scholar 

  59. Husain S, Scher RK, Silvers DN, Ackerman AB. Melanotic macule of nail unit and its clinicopathologic spectrum. J Am Acad Dermatol. 2006;54(4):664–7.

    Article  PubMed  Google Scholar 

  60. Baran R, Kechijian P. Longitudinal melanonychia (melanonychia striata): diagnosis and management. J Am Acad Dermatol. 1989;21(6):1165–75.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Neelam A. Vashi .

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Higham, C.M., Vashi, N.A. (2017). Physiologic Pigmentation. In: Vashi, N., Maibach, H. (eds) Dermatoanthropology of Ethnic Skin and Hair. Springer, Cham. https://doi.org/10.1007/978-3-319-53961-4_7

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  • DOI: https://doi.org/10.1007/978-3-319-53961-4_7

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