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Reversible War-Induced Renal Failure

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Complicated War Trauma and Care of the Wounded
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Abstract

A 42-year-old Syrian citizen was admitted to the internal department from the intensive care unit after war injury. Laparotomy and splenectomy had been undertaken in another hospital few days before admission to our hospital.

On admission to the hospital, he was fully conscious, pale, and dyspneic; a deep wound on his buttock and a surgical suture with serous discharge were noted on his left upper abdomen.

Laboratory examination reveals creatinine 10 mg% and hemoglobin 8 g%, and metabolic acidosis was noted on arterial blood gases.

He was treated with massive blood and fluid resuscitation and hemodialysis with gradual amelioration.

Acute tubular necrosis secondary to blood loss and nephrotoxic antibiotic drug treatment was assumed as the main mechanism to explain his acute renal failure.

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References

  1. Nash K, Hafeez A, Hou S. Hospital-acquired renal insufficiency. Am J Kidney Dis. 2002;39:930.

    Article  PubMed  Google Scholar 

  2. Bagshaw SM, Bellomo R, Kellum JA. Oliguria, volume overload, and loop diuretics. Crit Care Med. 2008;36:S172.

    Article  PubMed  Google Scholar 

  3. Grams ME, Estrella MM, Coresh J, et al. Fluid balance, diuretic use, and mortality in acute kidney injury. Clin J Am Soc Nephrol. 2011;6:966.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Goldstein SL, Somers MJ, Baum MA, et al. Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy. Kidney Int. 2005;67:653.

    Article  PubMed  Google Scholar 

  5. Payen D, de Pont AC, Sakr Y, et al. A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit Care. 2008;12:R74.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Bouchard J, Soroko SB, Chertow GM, et al. Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int. 2009;76:422.

    Article  PubMed  Google Scholar 

  7. Kraut JA, Kurtz I. Use of base in the treatment of severe acidemic states. Am J Kidney Dis. 2001;38:703.

    Article  CAS  PubMed  Google Scholar 

  8. Marsh JD, Margolis TI, Kim D. Mechanism of diminished contractile response to catecholamines during acidosis. Am J Physiol. 1988;254:H20.

    CAS  PubMed  Google Scholar 

  9. Mitchell JH, Wildenthal K, Johnson Jr RL. The effects of acid-base disturbances on cardiovascular and pulmonary function. Kidney Int. 1972;1:375.

    Article  CAS  PubMed  Google Scholar 

  10. Teplinsky K, O'Toole M, Olman M, et al. Effect of lactic acidosis on canine hemodynamics and left ventricular function. Am J Physiol. 1990;258:H1193.

    CAS  PubMed  Google Scholar 

  11. Orchard CH, Kentish JC. Effects of changes of pH on the contractile function of cardiac muscle. Am J Physiol. 1990;258:C967.

    CAS  PubMed  Google Scholar 

  12. Mathieu D, Neviere R, Billard V, et al. Effects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: a prospective, controlled clinical study. Crit Care Med. 1991;19:1352.

    Article  CAS  PubMed  Google Scholar 

  13. Orchard CH, Cingolani HE. Acidosis and arrhythmias in cardiac muscle. Cardiovasc Res. 1994;28:1312.

    Article  CAS  PubMed  Google Scholar 

  14. Kraut JA, Madias NE. Treatment of acute metabolic acidosis: a pathophysiologic approach. Nat Rev Nephrol. 2012;8:589.

    Article  CAS  PubMed  Google Scholar 

  15. Heparin ML, Goldstein MB. Metabolic acidosis. In:Fluid, electrolyte and acid-base physiology. Philadelphia: WB Saunders; 1993.

    Google Scholar 

  16. Dellinger RP, Levy MM, Carlet JM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36:296.

    Article  PubMed  Google Scholar 

  17. Cooper DJ, Walley KR, Wiggs BR, Russell JA. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study. Ann Intern Med. 1990;112:492.

    Article  CAS  PubMed  Google Scholar 

  18. Glaser N, Barnett P, McCaslin I, et al. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med. 2001;344:264.

    Article  CAS  PubMed  Google Scholar 

  19. Massry SG, Stein R, Garty J, et al. Skeletal resistance to the calcemic action of parathyroid hormone in uremia: role of 1,25 (OH)2 D3. Kidney Int. 1976;9:467.

    Article  CAS  PubMed  Google Scholar 

  20. Massry SG, Arieff AI, Coburn JW, et al. Divalent ion metabolism in patients with acute renal failure: studies on the mechanism of hypocalcemia. Kidney Int. 1974;5:437.

    Article  CAS  PubMed  Google Scholar 

  21. Tohme JF, Bilezikian JP. Diagnosis and treatment of hypocalcemic emergencies. Endocrinologist. 1996;6:10.

    Article  Google Scholar 

  22. Fiaccadori E, Cremaschi E. Nutritional assessment and support in acute kidney injury. Curr Opin Crit Care. 2009;15:474.

    Article  PubMed  Google Scholar 

  23. Krishnan JA, Parce PB, Martinez A, et al. Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes. Chest. 2003;124:297.

    Article  PubMed  Google Scholar 

  24. Bellomo R, Seacombe J, Daskalakis M, et al. A prospective comparative study of moderate versus high protein intake for critically ill patients with acute renal failure. Ren Fail. 1997;19:111.

    Article  CAS  PubMed  Google Scholar 

  25. Fouque D, Kalantar-Zadeh K, Kopple J, et al. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int. 2008;73:391.

    Article  CAS  PubMed  Google Scholar 

  26. McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). J Parenter Enteral Nutr. 2009;33:277.

    Article  Google Scholar 

  27. Fiaccadori E, Maggiore U, Giacosa R, et al. Enteral nutrition in patients with acute renal failure. Kidney Int. 2004;65:999.

    Article  PubMed  Google Scholar 

  28. Li Y, Tang X, Zhang J, Wu T. Nutritional support for acute kidney injury. Cochrane Database Syst Rev 2010:CD005426.

    Google Scholar 

  29. Lameire N, Van Biesen W, Vanholder R. Acute renal failure. Lancet. 2005;365:417.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Raymond Farah .

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Farah, R., Ben-Dror, G. (2017). Reversible War-Induced Renal Failure. In: Zarka, S., Lerner, A. (eds) Complicated War Trauma and Care of the Wounded . Springer, Cham. https://doi.org/10.1007/978-3-319-53339-1_23

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  • DOI: https://doi.org/10.1007/978-3-319-53339-1_23

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  • Online ISBN: 978-3-319-53339-1

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