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The Midbody and its Remnant in Cell Polarization and Asymmetric Cell Division

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Asymmetric Cell Division in Development, Differentiation and Cancer

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 61))

Abstract

The midbody is a protein-dense assembly that forms during cytokinesis when the actomyosin ring constricts around bundling central spindle microtubules. After its initial description by Walther Flemming in the late nineteenth century and its rediscovery through electron microscopy in the 1960s and 1970s, its ultrastructural organization and the sequential recruitment of its molecular constituents has only been elucidated in the past decade. Recently, it has become clear that the midbody can serve as a polarity cue during asymmetric cell division, cell polarization, and spindle orientation by coordinating cytoskeletal organization, vesicular transport, and localized cortical cues. In this chapter, these newly emerging functions will be discussed as well as asymmetries during midbody formation and their consequences for cellular organization in tissues.

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Acknowledgements

Research in the laboratory of CP is funded by the Deutsche Forschungsgemeinschaft (EXC 115, FOR 1756, SFB 1177) and the LOEWE Research Cluster Ubiquitin Networks. CP’s research concerning developmental functions of the midbody was supported by a European Union Framework Program 7 fellowship (Marie Curie Actions Project 326632).

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  1. Buchmann Institute for Molecular Life Sciences, Institute of Biochemistry II, Goethe University Medical School, Max-von-Laue-Strasse 15, 60438, Frankfurt (Main), Germany

    Christian Pohl

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  1. IGDR, UMR 6290, CNRS, Université de Rennes 1, Rennes, France

    Jean-Pierre Tassan

  2. Inst of Genetics & Dev of Rennes IG, CNRS/Unive Rennes 1 UMR 6290, Rennes Cedex, France

    Jacek Z. Kubiak

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Pohl, C. (2017). The Midbody and its Remnant in Cell Polarization and Asymmetric Cell Division. In: Tassan, JP., Kubiak, J. (eds) Asymmetric Cell Division in Development, Differentiation and Cancer. Results and Problems in Cell Differentiation, vol 61. Springer, Cham. https://doi.org/10.1007/978-3-319-53150-2_7

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