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Multiple Sclerosis and EIF2B5: A Paradox or a Missing Link

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Multiple Sclerosis: Bench to Bedside

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 958))

Abstract

Multiple sclerosis (MS) is an encumbering inflammatory condition of the central nervous system (CNS) caused by axonal demyelination. There is sufficient evidence suggesting role of eukaryotic translation initiation factor 2B (EIF2B) gene family encoding the five subunits of eIF2B complex-α, β, γ, δ and ε respectively, in causing vanishing white matter (VWM) disease of the brain. Incidentally researchers have proposed overlapping between MS and VWM in terms of clinical, biochemical and genetic aspects, which incited us to write this chapter to explore the association between EIF2B5 and MS. eIF2B plays an essential role in translation initiation and its regulation in eukaryotes. Among EIF2B gene family, EIF2B5 gene encodes the catalytic and a crucial epsilon subunit of the eIF2B protein as most of the alterations have been found in this gene. The recent findings on the association between EIF2B5 and MS susceptibility point towards unfathomable and contentious role of EIF2B5 in MS development. This chapter briefly reviews the insights gleaned from recent studies conducted in understanding the association between EIF2B5 and MS risk. The need of hour is to conduct large scale conclusive studies aimed at expounding the mechanisms behind this relationship.

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Abbreviations

CD45:

protein tyrosine phosphatase receptor type C

CNS:

central nervous system

CYP27B1:

cytochrome P450 family 27 subfamily B member 1

ε:

epsilon

eIF2:

eukaryotic translation initiation factor 2

eIF2B:

eukaryotic translation initiation factor 2B

EIF2B5:

gene

eIF2B:

protein

GTP:

guanosine triphosphate

HIV:

human immunodeficiency virus

HLA:

human leukocyte antigen

HSP:

heat shock proteins

IL6:

interleukin 6

IL-7R:

interleukin 7 receptor

MS:

multiple sclerosis

MSIF:

multiple sclerosis international federation

OMIM:

online mendelian inheritance in man

PP:

primary progressive

PR:

primary relapsing

RR:

relapsing-remitting

SNP:

single nucleotide polymorphism

SP:

secondary progressive

VWM:

vanishing white matter

WHO:

world health organization

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Acknowledgements

The authors thank the Department of Science and Technology (DST), Govt. of India, New Delhi, for providing grants to the Principal Investigator, Dr. Insha Zahoor, under the Women Scientist Scheme-A (WOS-A) project on Multiple Sclerosis vide Order No.: SR/WOS-A/LS-72/2013(G).

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Authors and Affiliations

  1. Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Insha Zahoor & Ehtishamul Haq

  2. Department of Neurology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India

    Ravouf Asimi

Authors
  1. Insha Zahoor
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  2. Ehtishamul Haq
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  3. Ravouf Asimi
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Corresponding author

Correspondence to Insha Zahoor .

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Editors and Affiliations

  1. Department of Neuroscience Research, University of Dammam, Damman, Saudi Arabia

    Alexzander A. A. Asea

  2. Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy

    Fabiana Geraci

  3. Department of Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA

    Punit Kaur

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Zahoor, I., Haq, E., Asimi, R. (2017). Multiple Sclerosis and EIF2B5: A Paradox or a Missing Link. In: Asea, A., Geraci, F., Kaur, P. (eds) Multiple Sclerosis: Bench to Bedside. Advances in Experimental Medicine and Biology, vol 958. Springer, Cham. https://doi.org/10.1007/978-3-319-47861-6_5

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