Abstract
Parasites are organisms that depend on a host for feeding and reproduction and belong to various unrelated taxa, primarily protozoa, helminths and arthropods. Complex life cycles have often lead to extreme adaptations; nevertheless parasites may harm their hosts and even cause serious disease and death. Transmission of parasite stages can be environmental, nutritional or vector-borne. Among the most important human protozoan parasites in a global context are Leishmania, Plasmodium (both transmitted by bloodsucking arthropods) and Toxoplasma which is soil- or food-borne. Parasitic worms (helminths) relevant for human health include Echinococcus, Toxocara, hookworms (all soil-borne) and Dirofilaria (transmitted by mosquitoes). Various arthropods (ticks, insects) are involved in the transmission of pathogens due to their blood-feeding behaviour. They are especially involved in transmission cycles between animals and humans (zoonotic infections). Research on parasites and their interactions with the host requires suitable animal models. For parasites with a wide host range or those naturally infecting rodent species available as laboratory animals, established models are available. Others, like the human malaria parasites, require sophisticated and often costly genetic manipulation to allow for infection in non-natural rodent hosts. Alternatively, surrogate models of closely related helminth species in rodent models are used to study human parasites.
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Literature
Auer H, Aspöck H (2014a) Helminths and helminthoses in Central Europe: general overview and diseases caused by trematodes (flukes). Wien Med Wochenschr 164(19–20):405–413
Auer H, Aspöck H (2014b) Helminths and helminthoses in Central Europe: diseases caused by cestodes (tapeworms). Wien Med Wochenschr 164(19–20):414–423
Auer H, Aspöck H (2014c) Helminths and helminthoses in Central Europe: diseases caused by nematodes (roundworms). Wien Med Wochenschr 164(19–20):424–434
Delves M, Plouffe D, Scheurer C, Meister S, Wittlin S, Winzeler EA, Sinden RE, Leroy D (2012) The activities of current antimalarial drugs on the life cycle stages of plasmodium: a comparative study with human and rodent parasites. PLoS Med 9(2):e1001169
Dubey JP, Beattie C (1988) Toxoplasmosis of animals and man. CRC Press. Inc., Boca Raton
Finkelman FD, Shea-Donohue T, Goldhill J, Sullivan CA, Morris SC, Madden KB, Gause WC, Urban JF Jr (1997) Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. Annu Rev Immunol 15:505–533
Frech C, Chen N (2011) Genome comparison of human and non–human malaria parasites reveals species subset–specific genes potentially linked to human disease. PLoS Comput Biol 7(12):e1002320
Good MF, Hawkes MT, Yanow SK (2015) Humanized mouse models to study cell–mediated immune responses to liver-stage malaria vaccines. Trends Parasitol 31(11):583–594
Gramiccia M, Gradoni L (2005) The current status of zoonotic leishmaniases and approaches to disease control. Int J Parasitol 35(11–12):1169–1180
Lipoldová M, Demant P (2006) Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Nat Rev Genet 7(4):294–305
Louis JA, Conceiçao–Silva F, Himmelrich H, Tacchini–Cottier F, Launois P (1998) Anti–leishmania effector functions of CD4+ Th1 cells and early events instructing Th2 cell development and susceptibility to Leishmania major in BALB/c mice. Adv Exp Med Biol 452:53–60
Mlambo G, Kumar N (2008) Transgenic rodent Plasmodium berghei parasites as tools for assessment of functional immunogenicity and optimization of human malaria vaccines. Eukaryot Cell 7(11):1875–1879
Poeppl W, Obwaller A, Weiler M, Burgmann H, Mooseder G, Lorentz S, Rauchenwald F, Aspöck H, Walochnik J, Naucke TJ (2013) Emergence of sandflies (Phlebotominae) in Austria, a Central European country. Parasitol Res 112(12):4231–4237
Sack DL, Melby PC (2015) Animal models for the analysis of immune responses to leishmaniasis. Curr Protoc Immunol 108:19.2.1–19.2.24
Sibley LD, Mordue D, Howe DK (1999) Experimental approaches to understanding virulence in toxoplasmosis. Immunobiology 201(2):210–224
Sibley LD, Mordue DG, Su C, Robben PM, Howe DK (2002) Genetic approaches to studying virulence and pathogenesis in Toxoplasma gondii. Philos Trans R Soc Lond B Biol Sci 357(1417):81–88
Solano-Gallego L, Riera C, Roura X, Iniesta L, Gallego M, Valladares JE, Fisa R, Castillejo S, Alberola J, Ferrer L, Arboix M, Portús M (2001) Leishmania infantum–specific IgG, IgG1 and IgG2 antibody responses in healthy and ill dogs from endemic areas. Evolution in the course of infection and after treatment. Vet Parasitol 96(4):265–276
Subauste C (2012) Animal models for Toxoplasma gondii infection. Curr Protoc Immunol 19:19.3.1–19.3.23
Tenter AM, Heckeroth AR, Weiss LM (2000) Toxoplasma gondii: from animals to humans. Int J Parasitol 30(12–13):1217–1258
Walochnik J, Aspöck H (2012) Protozoan pathogens: identification. In: Encyclopedia of life sciences (ELS), 3rd edn. John Wiley and Sons Ltd, Chichester
Walochnik J, Aspöck H (2014) Protozoa and protozoan infections of humans in Central Europe. Wien Med Wochenschr 164(19–20):435–445 [in German]
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Walochnik, J., Auer, H., Joachim, A. (2017). Parasitic Infections in Humans and Animals. In: Jensen-Jarolim, E. (eds) Comparative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-47007-8_12
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DOI: https://doi.org/10.1007/978-3-319-47007-8_12
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