Skip to main content

Chronic Venous Disease and Varicose Veins

  • Chapter
  • First Online:
Vascular Diseases for the Non-Specialist

Abstract

The lower limb venous system is responsible for the return of the blood from the leg toward the heart. Chronic venous disease occurs by a deficiency in the blood return due to structural or functional abnormalities of the veins of the lower limbs. Insufficient venous return leads to the accumulation of blood in the lower limbs and to varying degrees of venous hypertension, presenting a wide spectrum of clinical manifestations, ranging from simple telangiectasies and varicose veins to advanced forms. Chronic venous disease has a large prevalence in the world population and has significant impact on health services for high demand due to disease symptoms, activity limitation and aesthetic concern. Common symptoms are pain, cramps, heaviness, edema, and lower limb ulcer. The presence of tortuous and dilated veins must be noted, as well as telangiectasies, angiomatous formation, edema, and trophic skin alterations. CEAP classification has been proposed in order to standardize the scientific publications about varicose veins and therapeutic indications. Chronic venous disease treatment involves no interventionist actions to control symptoms and improve the quality of life with physical activity, compression therapy, phlebotropic agents, and interventional treatment such as sclerotherapy, transdermal laser, or surgery. Today, we have the minimally invasive methods as an alternative of surgery: endovenous ablation with laser or radiofrequency and foam sclerotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rutherford RB. Venous physiology. In: Rutherford RB, editor. Vascular surgery. 8th ed. Philadelphia: WB Saunders; 2014. p. 150–3.

    Google Scholar 

  2. Rutherford RB. Chronic venous disorders: general considerations. In: Rutherford RB, editor. Vascular surgery. 8th ed. Philadelphia: WB Saunders; 2014. p. 843–56.

    Google Scholar 

  3. Nicolaides AN, et al. Investigation of chronic venous insufficiency: a consensus statement. Circulation. 2000;102:126–63.

    Article  Google Scholar 

  4. National Institute for Health and Care Excellence: Clinical Guidelines. Varicose veins in the legs: the diagnosis and management of varicose veins. Copyright National clinical Guideline Centre; July 2013.

    Google Scholar 

  5. Abramson JH, Hopp C, Epstein LM. The epidemiology of varicose veins. A survey in western Jerusalem. J Epidemiol Community Health. 1981;35(3):213–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Beaglehold R, Salmond CE, Prior IA. Varicose veins in New Zealand: prevalence and severity. N Z Med J. 1976;84(576):396–9.

    CAS  PubMed  Google Scholar 

  7. Coon WW, Willis 3rd PW, Keller JB. Venous thromboembolism and other venous disease in the Tecumseh community health study. Circulation. 1973;48(4):839–46.

    Article  CAS  PubMed  Google Scholar 

  8. Brand FN, Dannenberg AL, Abbott RD, Kannel WB. The epidemiology of varicose veins: the Framingham Study. Am J Prev Med. 1988;4(2):96–101.

    CAS  PubMed  Google Scholar 

  9. Burnand KG. The physiology and hemodynamics of chronic venous insufficiency of the lower limb. In: Gloviczki P et al., editors. Handbook of venous disorders. 2nd ed. New York: Arnold Publisher; 2001. p. 49–57.

    Google Scholar 

  10. Rutherford RB. Venous pathology. In: Rutherford RB, editor. Vascular surgery. 8th ed. Philadelphia: WB Saunders; 2014. p. 170–3.

    Google Scholar 

  11. Navarro TP, Delis KT, Ribeiro AP. Clinical and hemodynamic significance of the greater saphenous vein diameter in chronic venous insufficiency. Arch Surg. 2002;137:1233–7.

    Article  PubMed  Google Scholar 

  12. Goren G, Yellin AE. Primary varicose veins: topographic and hemodynamic correlations. J Cardiovasc Surg (Torino). 1990;31:672–7.

    CAS  Google Scholar 

  13. Nicolaides AN, et al. The value of dynamic venous pressure measurements. World J Surg. 1986;10:919–24.

    Article  CAS  PubMed  Google Scholar 

  14. Skene AI, Smith JM, Dore CJ, Charlett A, Lewis JD. Venous leg ulcer: a prognostic index to predict time to healing. BMJ. 1992;305:1119–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Callum MJ, Harper DR, Dale JJ. Chronic ulcer of the leg: clinical history. Br Med J. 1987;294:1389–91.

    Article  Google Scholar 

  16. Mayberry JC, Moneta GL, De Frang RD, Porter JM. The influence of elastic compression stockings on deep venous hemodynamics. J Vasc Surg. 1991;13:91–100.

    Article  CAS  PubMed  Google Scholar 

  17. Dinn E, Henry M. Treatment of venous ulceration by injection sclerotherapy and compression hosiery: a 5 year study. Phlebology. 1992;7:23–6.

    Article  Google Scholar 

  18. Nelzen O. Prevalence of venous leg ulcer: the importance of the data collection method. Phlebolymphology. 2008;15(4):143–50.

    Google Scholar 

  19. Caprini JA. Risk assessment as a guide to thrombosis prophylaxis. Curr Opin Pulm Med. 2010;16(5):448–52.

    Article  PubMed  Google Scholar 

  20. Decousus H, Quéré I, Presles E, et al. Superficial venous thrombosis and venous thromboembolism: a large, prospective epidemiologic study. Ann Intern Med. 2010;152:218–24.

    Article  PubMed  Google Scholar 

  21. Eberhardt RT, et al. Contemporary review in cardiovascular medicine. Chronic venous insufficiency. Circulation. 2005;111:2398–409.

    Article  PubMed  Google Scholar 

  22. Eklöf B, Rutherford RB, Bergan JJ, Carpentier PH, et al. Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg. 2004;40:1248–52.

    Article  PubMed  Google Scholar 

  23. Partsch B, et al. Calf compression pressure required to achieve venous closure from supine to standing positions. J Vasc Surg. 2005;42:734–8.

    Article  PubMed  Google Scholar 

  24. Rutherford RB. Chronic venous disorders: nonoperative treatment. In: Rutherford RB, editor. Vascular surgery. 8th ed. Philadelphia: WB Saunders; 2014. p. 858–67.

    Google Scholar 

  25. Bergan JJ, Sparks SR. Non-elastic compression: an alternative in management of chronic venous insufficiency. J Wound Ostomy Continence Nurs. 2000;27(2):83–9.

    CAS  PubMed  Google Scholar 

  26. Feldman JL, et al. Intermittent pneumatic compression therapy: a systematic review. Lymphology. 2012;45:13–25.

    CAS  PubMed  Google Scholar 

  27. Ramlet AA. Pharmacologic aspects of a phlebotropic drug in CVI associated edema. Angiology. 2000;51:19–23.

    Article  Google Scholar 

  28. Martinez MJ, et al. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2005;3:CD003229.

    Google Scholar 

  29. Scallon C, Bell-Syer SE, Aziz Z. Flavonoids for treating venous leg ulcers. Cochrane Database Syst Rev. 2013;5:CD006477.

    Google Scholar 

  30. Thibault P. Sclerotherapy and ultrasound-guided sclerotherapy. In: Bergan J, editor. The vein book. Boston: Elsevier; 2007.

    Google Scholar 

  31. Gloviczki P, et al. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011;53(5):2–48.

    Article  Google Scholar 

  32. Rutherford RB. Varicose veins: endovenous ablation and sclerotherapy. In: Rutherford RB, editor. Vascular surgery. 8th ed. Philadelphia: WB Saunders; 2014. p. 885–901.

    Google Scholar 

  33. Scultetus AH, et al. Microthrombectomy reduces postsclerotherapy pigmentation: multicenter randomized trial. J Vasc Surg. 2003;38:896–903.

    Article  PubMed  Google Scholar 

  34. Sadick NS. Laser treatment of leg veins. Skin Ther Lett. 2004;9.

    Google Scholar 

  35. Passeron T, et al. The new 940 nanometer diode laser: an effective treatment for leg venulectasia. J Am Acad Dermatol. 2003;48:768–74.

    Article  PubMed  Google Scholar 

  36. Fournier N, et al. Treatment of leg telangiectasias with a 532 nm KTP laser in multi-pulse model. Dermatol Surg. 2002;28:564–71.

    CAS  PubMed  Google Scholar 

  37. Anderson RR, et al. Mechanisms of selective vascular changes caused by dye lasers. Lasers Surg Med. 1983;3:211–5.

    Article  CAS  PubMed  Google Scholar 

  38. Sadick N, et al. Laser treatment of telangiectasias and reticular veins. In: Bergan J, editor. The vein book. Boston: Elsevier; 2007.

    Google Scholar 

  39. Lupton J, et al. Clinical comparison of sclerotherapy versus long-pulsed Nd: YAG laser treatment for lower extremity telangiectasias. Dermatol Surg. 2002;28:694–7.

    PubMed  Google Scholar 

  40. Carroll C, Hummel S, Leaviss J, Ren S, Stevens JW, Everson-Hock E, Cantrell A, Stevenson M, Michaels J. Clinical effectiveness and cost-effectiveness of minimally invasive techniques to manage varicose veins: a systematic review and economic evaluation. Health Technol Assess. 2013;17(48):i–xvi, 1–141.

    Google Scholar 

  41. VNUS Medical Technologies, Inc. VNUS Closure FAST Radiofrequency brochure. San Jose: VNUS Medical Technologies Inc [VN25-91-A]; 2006.

    Google Scholar 

  42. Goldman MP. Intravascular lasers in the treatment of varicose veins. J Cosmet Dermatol. 2004;3:162–6.

    Article  CAS  PubMed  Google Scholar 

  43. Rasmussen LH, et al. Randomized trial comparing endovenous laser ablation of the great saphenous vein with high ligation and stripping in patients with varicose veins: short-term results. J Vasc Surg. 2007;46:308–15.

    Article  PubMed  Google Scholar 

  44. Rasmussen LH, et al. Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Br J Surg. 2011;98:1079–87.

    Article  CAS  PubMed  Google Scholar 

  45. Siribumrungwong B, Noorit P, Wilasrusmee C, Attia J, Thakkinstian A. A systematic review and meta-analysis of randomized controlled trials comparing endovenous ablation and surgical intervention in patients with varicose vein. Eur J Vasc Endovasc Surg. 2012;44(2):214–23.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Maíra Faria Braga Pires .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Pires, M.F.B., Nogueira, R.F., Navarro, T.P. (2017). Chronic Venous Disease and Varicose Veins. In: Navarro, T., Dardik, A., Junqueira, D., Cisneros, L. (eds) Vascular Diseases for the Non-Specialist. Springer, Cham. https://doi.org/10.1007/978-3-319-46059-8_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-46059-8_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-46057-4

  • Online ISBN: 978-3-319-46059-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics