Abstract
Adrenomedullary chromaffin cells are widely used as a valuable model to study calcium-induced exocytosis of dense vesicles. Functional studies demonstrated the important role of organelles in shaping calcium signals in this cell type. Therefore, the study of mitochondria distribution in relation with exocytotic sites is relevant to understand the nature of such modulation. In this paper, we discuss the spatial distribution of mitochondria in bovine chromaffin cells in culture inferred from experimental observations and use a theoretical model for understanding the role played by these organelles in the fine tuning of calcium signals and the modulation of secretion.
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Acknowledgements
This study was supported by grants from the Spanish Ministerio de Economia y Competitividad (BFU2011-25095 to LMG).
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Gil, A., González-Vélez, V., Villanueva, J., Gutiérrez, L.M. (2017). Understanding the Role of Mitochondria Distribution in Calcium Dynamics and Secretion in Bovine Chromaffin Cells. In: Graw, F., Matthäus, F., Pahle, J. (eds) Modeling Cellular Systems. Contributions in Mathematical and Computational Sciences, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-319-45833-5_5
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DOI: https://doi.org/10.1007/978-3-319-45833-5_5
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