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Immunosenescence and the Ageing Lung

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The Ageing Immune System and Health

Abstract

Ageing is generally defined as the progressive decline of homeostasis that occurs after the reproductive phase of life is complete and the “soma becomes disposable” and death is inevitable according to one theory of ageing. The complexity of the ageing process becomes strikingly evident in the lung where tissue maintenance and repair suffer from damage at the genetic level as well as tissue level. Moreover, lung function declines steadily in adulthood and if data for older adults are extrapolated, the outcome suggests an upper age limit beyond which life becomes impossible. In this chapter we cover the main changes to lung structure and function with age and the impact on respiratory health. We also describe the role that an aged immune system may play in the age-related decline in lung function and the major involvement of altered signalling through developmental pathways with special focus on PPARγ.

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Authors and Affiliations

  1. Department of Pharmaceutical Biotechnology, School of Pharmacy, and Szentagothai Research Center, University of Pecs, 2 Rokus Str, Pecs, 7624, Hungary

    Krisztian Kvell & Judit E. Pongracz

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  1. Krisztian Kvell
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  2. Judit E. Pongracz
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Correspondence to Judit E. Pongracz .

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Editors and Affiliations

  1. Department of Microbiology, Immunology and Parasitology UNIFESP Federal University of São Paulo, Sao Paulo, São Paulo, Brazil

    Valquiria Bueno

  2. MRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing Birmingham University Medical School Birmingham, Birmingham, United Kingdom

    Janet M. Lord

  3. Institute of Inflammation and Ageing, University of Birmingham University of Birmingham Research Laboratories, Birmingham, United Kingdom

    Thomas A. Jackson

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Kvell, K., Pongracz, J.E. (2017). Immunosenescence and the Ageing Lung. In: Bueno, V., Lord, J., Jackson, T. (eds) The Ageing Immune System and Health. Springer, Cham. https://doi.org/10.1007/978-3-319-43365-3_6

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