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Pendrin and Its Partners in the Kidney: Roles in Vascular Volume and Acid Base Regulation

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The Role of Pendrin in Health and Disease

Abstract

The Cl−/HCO3 − exchanger pendrin (SLC26A4, PDS) is located on the apical membrane of B-intercalated cells in the kidney cortical collecting duct (CCD) and the connecting tubules (CNTs) and mediates the secretion of bicarbonate and the reabsorption of chloride. Recent studies demonstrate the coordinated interaction of pendrin with several ion transporters and/or channels in the kidney distal nephron, resulting in systemic electrolyte and vascular volume homeostasis and acid base regulation. In this chapter, we will discuss the latest developments on the role of pendrin and its interacting partners in salt and water absorption in the distal nephron and their relevance to pathophysiologic states.

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Authors and Affiliations

  1. Department of Medicine, University of Cincinnati, Cincinnati, OH, USA

    Manoocher Soleimani MD

  2. Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy

    Giovanna Valenti PhD

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  1. Manoocher Soleimani MD
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  2. Giovanna Valenti PhD
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Correspondence to Manoocher Soleimani MD or Giovanna Valenti PhD .

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Editors and Affiliations

  1. Paracelsus Medical University Institute of Pharmacology and Toxicology, Salzburg, Austria

    Silvia Dossena

  2. Paracelsus Medical University Institut of Pharmacology and Toxicology, Salzburg, Austria

    Markus Paulmichl

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Soleimani, M., Valenti, G. (2017). Pendrin and Its Partners in the Kidney: Roles in Vascular Volume and Acid Base Regulation. In: Dossena, S., Paulmichl, M. (eds) The Role of Pendrin in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-43287-8_8

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