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Intralesional Collagenase Injection

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Atlas of Office Based Andrology Procedures

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Abstract

Collagenase clostridium histolyticum (Xiaflex®) is an enzyme, which acts to breakdown the collagenous Peyronie’s plaque. This enzyme is injected directly into the Peyronie’s plaque. The injection technique takes less than 2 min in duration. Bleeding complications (ecchymosis, hematoma formation) and penile fracture (corporal rupture) are the main complications.

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Suggested Reading

  • Auxillium Pharmaceuticals, Inc. Xiaflex—Collagenase clostridium histolyticum, Full Prescribing Information.

    Google Scholar 

  • Gelbard M, Goldstein I, Hellstrom WJ, McMahon CG, Smith T, Tursi J, et al. Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies. J Urol. 2013;190(1):199–207.

    Article  CAS  PubMed  Google Scholar 

  • Hellstrom WJ, Feldman RA, Coyne KS, Kaufman GJ, Smith TM, Tursi JP, et al. Self-report and clinical response to Peyronie’s disease treatment: Peyronie’s disease questionnaire results from 2 large double-blind, randomized, placebo-controlled phase 3 studies. Urology. 2015;86(2):291–8.

    Article  PubMed  Google Scholar 

  • Jordan GH, Carson CC, Lipshultz LI. Minimally invasive treatment of Peyronie’s disease: evidence-based progress. BJU Int. 2014;114(1):16–24.

    Article  PubMed  Google Scholar 

  • Levine LA, Cuzin B, Mark S, Gelbard MK, Jones NA, Liu G, et al. Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie’s disease: a phase 3 open-label study. J Sex Med. 2015;12(1):248–58.

    Article  PubMed  Google Scholar 

  • Lipshultz LI, Goldstein I, Seftel AD, Kaufman GJ, Smith TM, Tursi JP, et al. Clinical efficacy of collagenase Clostridium histolyticum in the treatment of Peyronie’s disease by subgroup: results from two large, double-blind, randomized, placebo-controlled, phase III studies. BJU Int. 2015;116(4):650–6.

    Article  CAS  PubMed  Google Scholar 

  • Peak TC, Mitchell GC, Yafi FA, Hellstrom WJ. Role of collagenase clostridium histolyticum in Peyronie’s disease. Biologics. 2015;9:107–16.

    PubMed  PubMed Central  Google Scholar 

  • Ziegelmann MJ, Viers BR, McAlvany KL, Bailey GC, Savage JB, Trost LW. Restoration of penile function and patient satisfaction with intralesional collagenase clostridium histolyticum injection for Peyronie’s disease. J Urol. 2016;195(4P1):1051–6.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Surgery, Section of Urology, Memorial Sloan Kettering Cancer Center, 16 East 60th Street, Suite 402, New York, NY, 10022, USA

    John P. Mulhall MD, MSc, FECSM, FACS & Lawrence C. Jenkins MD, MBA

Authors
  1. John P. Mulhall MD, MSc, FECSM, FACS
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  2. Lawrence C. Jenkins MD, MBA
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Corresponding author

Correspondence to John P. Mulhall MD, MSc, FECSM, FACS .

Editor information

Editors and Affiliations

  1. Section of Urology Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

    John P. Mulhall

  2. Section of Urology Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA

    Lawrence C. Jenkins

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© 2017 Springer International Publishing Switzerland

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Mulhall, J.P., Jenkins, L.C. (2017). Intralesional Collagenase Injection. In: Mulhall, J., Jenkins, L. (eds) Atlas of Office Based Andrology Procedures. Springer, Cham. https://doi.org/10.1007/978-3-319-42178-0_11

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  • DOI: https://doi.org/10.1007/978-3-319-42178-0_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42176-6

  • Online ISBN: 978-3-319-42178-0

  • eBook Packages: MedicineMedicine (R0)

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