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Heterologous Pathway Engineering

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Metabolic Engineering for Bioprocess Commercialization

Abstract

Heterologous pathways encompass both natural and artificial biosynthetic routes. Expression of a heterologous pathway expands the molecular diversity that can be realized by the host organism. The engineering efforts often benefit from a well-established technological platform of the host. This chapter discusses recent progress and key challenges in implementing heterologous pathways. Major topics include enzyme discovery for artificial pathway assembly, methods for studying and tuning the performance of a pathway, and examples of heterologous pathway engineering.

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Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, University of Nebraska–Lincoln, Lincoln, NE, 68588, USA

    Wei Niu

  2. Department of Chemistry, University of Nebraska–Lincoln, Lincoln, NE, 68588, USA

    Jiantao Guo

  3. Genomatica, Inc., San Diego, CA, 92126, USA

    Steve Van Dien

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Correspondence to Wei Niu .

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  1. Genomatica, Inc. , San Diego, California, USA

    Stephen Van Dien

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Niu, W., Guo, J., Van Dien, S. (2016). Heterologous Pathway Engineering. In: Van Dien, S. (eds) Metabolic Engineering for Bioprocess Commercialization. Springer, Cham. https://doi.org/10.1007/978-3-319-41966-4_3

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