Abstract
Melanoma is steadily increasing in incidence while mortality is steady or only increasing slightly. Patterns of incidence, including anatomic site, differ by age and sex as well as geographic location. Light pigmentation and multiple nevi are critical risk factors for the development of melanoma as are family history and intermittent sun exposure. Tanning lamp exposure has been clearly identified as adverse risk for melanoma and other environmental factors are under new evaluation: pesticides, arsenic, polychlorinated biphenyls. Genetic factors modify response to environmental factors, and these are currently being uncovered.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aguilera P, Malvehy J, Carrera C, Palou J, Puig-Buille JA, Alos L, Badenas C, Puig S (2014) Clinical and histopathological characteristics between familial and sporadic melanoma in Barcelona, Spain. J Clin Exp Dermatol Res 5:231
Armstrong BK, Kricker A (1993) How much melanoma is caused by sun exposure? Melanoma Res 3:395–401
Armstrong BK, Kricker A (2001) The epidemiology of UV induced skin cancer. J Photochem Photobiol B 63:8–18
Armstrong BK, Kricker A, English DR (1997) Sun exposure and skin cancer. Australas J Dermatol 38(Suppl 1):S1–S6
Autier P, Dore JF (1998) Influence of sun exposures during childhood and during adulthood on melanoma risk. EPIMEL and EORTC Melanoma Cooperative Group. European Organisation for Research and Treatment of Cancer. Int J Cancer 77:533–537
Autier P, Koechlin A, Boniol M (2015) The forthcoming inexorable decline of cutaneous melanoma mortality in light-skinned populations. Eur J Cancer 51:869–878
Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Reintgen DS, Cascinelli N, Urist M, McMasters KM, Ross MI, Kirkwood JM, Atkins MB, Thompson JA, Coit DG, Byrd D, Desmond R, Zhang Y, Liu PY, Lyman GH, Morabito A (2001) Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 19:3622–3634
Barón AE, Asdigian NL, Gonzalez V, Aalborg J, Terzian T, Stiegmann RA, Torchia EC, Berwick M, Dellavalle RP, Morelli JG, Modrohisky ST, Crane LA, Box NF (2014) Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes. Cancer Epidemiol Biomarkers Prev 23:2829–2839
Beane Freeman LE, Dennis LK, Lynch CF, Thorne PS, Just CL (2004) Toenail arsenic content and cutaneous melanoma in Iowa. Am J Epidemiol 160:679–687
Bechetoille N, Dezutter-Dambuyant C, Damour O, Andre V, Orly I, Perrier E (2007) Effects of solar ultraviolet radiation on engineered human skin equivalent containing both Langerhans cells and dermal dendritic cells. Tissue Eng 13:2667–2679
Begg C, Berwick M (1997) A note on the estimation of relative risks of rare genetic susceptibility markers. Cancer Epidemiol Biomarkers Prev 6:99–103
Begg CB, Hummer A, Mujumdar U, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Klotz JB, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Berwick M, GEM Study Group (2004) Familial aggregation of melanoma risks in a large population-based sample of melanoma cases. Cancer Causes Control 15:957–965
Berthier-Vergnes O, Gaucherand M, Péguet-Navarro J, Plouet J, Pageaux JF, Schmitt D, Staquet MJ (2001) Human melanoma cells inhibit the earliest differentiation steps of human Langerhans cell precursors but failed to affect the functional maturation of epidermal Langerhans cells. Br J Cancer 85:1944–1951
Berwick M, Begg C, Fine JA, Roush GC, Barnhill RL. Screening for malignant melanoma by skin self-examination. J Natl Cancer Inst 1996:88:17–23. PMID 8847720
Berwick M, Chen YT (1995) Reliability of reported sunburn history in a case–control study of cutaneous malignant melanoma. Am J Epidemiol 141:1033–1037
Berwick M, Armstrong BK, Ben-Porat L, Fine J, Kricker A, Eberle C, Barnhill R (2005) Sun exposure and mortality from melanoma. J Natl Cancer Inst 97:195–199
Bradford PT, Anderson WF, Purdue MP, Goldstein AM, Tucker MA (2010) Rising melanoma incidence rates of the trunk among younger women in the United States. Cancer Epidemiol Biomarkers Prev 19:2401–2406
Bulliard J, Cox B (1999) Trends by anatomical site in Incidence of cutaneous malignant melanoma in Canada: 1963–1993. Cancer Causes Control 10:407–416
Bulger AL, Mayer JE, Gershenwald JE, Guild SR, Gottlieb MA, Geller AC (2015) Enforcement provisions of indoor tanning bans for minors: an analysis of the first 6 US states. Am J Public Health 105:310–312
Bulliard J, Cox B (2000) Incidence of cutaneous malignant melanoma in New Zealand by anatomical site: 1963–1993. Int J Epidemiol 29:416–423
Bykov VJ, Marcusson JA, Hemminki K (2000) Effect of constitutional pigmentation on ultraviolet B-induced DNA damage in fair-skinned people. J Invest Dermatol 114:40–43
Byrom L, Olsen CM, Knight L, Khosrotehrani K, Green AC (2015) Does pregnancy after a diagnosis of melanoma affect prognosis? Systematic review and meta-analysis. Dermatol Surg 41:875–882
Campbell LB, Kreicher BA, Gittleman HR, Strodtbeck K, Barnholtz-Sloan J, Bordeaux JS (2015) Melanoma incidence in children and adolescents: decreasing trends in the United States. J Pediatr 166:1505–1513
Chang C, Murzaku EC, Penn L, Abbasi NR, Davis PD, Berwick M, Polsky D (2014) More skin, more sun, more tan, more melanoma. Am J Public Health 104:e92–e99
Cho H, Mariotto AB, Schwartz LM, Luo J, Woloshin S (2014) When do changes in cnacer survival mean progress? the insight from population incidence and mortality. J Natl Cancer Inst Monogr 49:187–197
Clairwood M, Ricketts J, Grant-Kels J, Gonsalves L (2014) Melanoma in skin of color in Connecticut: an analysis of melanoma incidence and stage at diagnosis in non-Hispanic blacks, non-Hispanic whites, and Hispanics. Int J Dermatol 53:425–433
Cockburn MG, Zadnick J, Deapen D (2006) Developing epidemic of melanoma in the Hispanic population of California. Cancer 106:1162–1168
Criscione VD, Weinstock MA (2010) Melanoma thickness trends in the United States, 1988–2006. J Invest Dermatol 130:793–797
Crocetti E, Fancelli L, Manneschi G, Caldarella A, Pimpinelli N, Chiarugi A, Nardini P, Buzzoni C (2016) Melanoma survival: sex does matter, but we do not know how. Eur J Cancer Prev 25(5):404–409
de Giorgi V, Mavilla C, Massi D, Gozzini A, Aragona P, Tanini A, Sestini S, Paglieranti M, Boddi V, Brandi ML, Lottti T (2009) Estrogen receptor expression in cutaneous melanoma. Arch Dermatol 145:30–36
Dennis LK, Lynch CF, Sandler DP, Alavanja MC (2010) Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. Environ Health Perspect 118:812–817
deVries E, Nijsten TE, Visser O, Bastiaannet E, van Hattem S, Janssen-Heijnen ML, Coebergh JW (2008) Superior survival of females among 19,538 Dutch melanoma patients is independent of Breslow thickness, histologic type and tumor site. Ann Oncol 19:583–589
Diffey BL (2007) Sunbeds, beauty and melanoma. Br J Dermatol 157:215–216
Dinh QQ, Chong AH (2007) Melanoma in organ transplant recipients: the old enemy finds a new battleground. Australas J Dermatol 48:199–207
Elwood JM, Jopson J (1997) Melanoma and sun exposure: an overview of published studies. Int J Cancer 73:198–203
English DR, Armstrong BK, Kricker A (1998) Reproducibility of reported measurements of sun exposure in a case–control study. Cancer Epidemiol Biomarkers Prev 7:857–863
Erickson C, Driscoll MS (2010) Melanoma epidemic: facts and controversies. Clin Dermatol 28:281–286
Espinosa Arranz J, Sanchez Hernandez JJ, Bravo Fernandez P, Gonzalez-Baron M, Zamora Auñon P, Espinosa Arranz E, Jalon Lopez JI, Ordoñez GA (1999) Cutaneous malignant melanoma and sun exposure in Spain. Melanoma Res 2:199–205
Faurschou A, Wulf HC (2007) Ecological analysis of the relation between sunbeds and skin cancer. Photodermatol Photoimmunol Photomed 23:120–125
Ford D, Bliss JM, Swerdlow AJ, Armstrong BK, Franceschi S, Green A, Holly EA, Mack T, Mackie RM, Østerlind A, Walter SD, Peto J, Easton DF (1995) Risk of cutaneous melanoma associated with a family history of the disease. Int J Cancer 62:377–381
Gallagher RP, Elwood JM, Yang CP (1989) Is chronic sunlight exposure important in accounting for increases in melanoma incidence? Int J Cancer 44:813–815
Gallagher RP, Spinelli JJ, Lee TK (2005) Tanning beds, sunlamps and risk of cutaneous malignant melanoma. Cancer Epidemiol Biomarkers Prev 4:562–566
Gallagher RP, MacArthur AC, Lee TK, Weber J-P, Leblanc A, Elwood JM, Borugian M, Zbanto Z, Spinelli JJ (2011) Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma: a preliminary study. Int J Cancer 128(8):1872–1880
Gandini S, Sera F, Cattaruzza MS, Pasquini P, Picconi O, Boyle P, Melchi CF (2005) Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. Eur J Cancer 41:45–60
Garbe C, Buettner PG, Weiss J, Soyer HP, Stocker U, Krüger S, Roser M, Weckbecker J, Panizzon R, Bahmer F et al (1994) Risk factors for developing cutaneous melanoma and criteria for identifying persons at risk: multicenter case–control study of central malignant melanoma registry of the German dermatological society. J Invest Dermatol 102:695–699
Garbe C, McLeod GR, Buettner PG (2000) Time trends in cutaneous melanoma in Queensland, Australia and Central Europe. Cancer 89:1269–1278
Geller AC, Miller DR, Annas GD, Demierre MF, Gilchrest BA, Koh HK (2002) Melanoma incidence and mortality among US whites, 1969–1999. JAMA 288:1719–1720
Gould Rothberg BE, Rimm DL (2010) Biomarkers: the useful and the not so useful–an assessment of molecular prognostic markers for cutaneous melanoma. J Invest Dermatol 130:1971–1987
Green A (1992) A theory of the site distribution of melanomas: Queensland, Australia. Cancer Causes Control 3:513–516
Greene MH, Fraumeni JJ (1979) The hereditary variant of malignant melanoma. In: Clark WH, Goldman LI, Mastrangelo MJ (eds) Human malignant melanoma. Grune & Stratton, New York
Grob JJ, Richard MA, Gouvernet J, Avril MF, Delaunay M, Wolkenstein P, Souteyrand P, Bonerandi JJ, Machet L, Guillaume JC, Chevrant-Breton J, Vilmer C, Aubin F, Guillot B, Beylot-Barry M, Lok C, Raison-Peyron N, Chemaly P (2002) The kinetics of the visible growth of a primary melanoma reflects the tumor aggressiveness and is an independent prognostic marker: a prospective study. Int J Cancer 102:34–38
Guy GP Jr, Thomas CC, Thompson T, Watson M, Massetti GM, Richardson LC (2015) Vital signs: Melanoma incidence and mortality trends and projections – United States, 1982–2030. MMWR Morb Mortal Wkly Rep 64(21):591–596
Hersey P, Bradley DE, Hasic E, Haran G, Edwards A, McCarthy WH (1983) Immunological effects of solarium exposure. Lancet 1:545–548
Holly EA, Aston DA, Cress RD, Ahn DK, Kristiansen JJ (1995) Cutaneous melanoma in women. I. Exposure to sunlight, ability to tan, and other risk factors related to ultraviolet light. Am J Epidemiol 141:923–933
Huynh PM, Glusac EJ, Alvarez-Franco M, Berwick M, Bolognia J (2003) Numerous small darkly pigmented melanocytic nevi: the cheetah phenotype. J Am Acad Dermatol 48:707–713
International Agency for Research on Cancer (WHO) and International Association of Cancer Registries; Curado MP, Edwards B, Shin HR, Storm H, Ferlay J, Heanue M, Boyle P (eds) (2007) Cancer incidence in five continents, vol 9. IARC Scientific Publication No. 160. International Agency for Research on Cancer, Lyon
International Agency for Research on Cancer Working Group on artificial ultraviolet (UV) light and skin cancer (2007) The association of use of sunbeds with cutaneous malignant melanoma and other skin cancers: a systematic review. Int J Cancer 120:1116–1122
Juhl AL, Byers TE, Robison WA, Morelli JG, Crane LA (2009) The anatomic distribution of melanoma and relationships with childhood nevus distribution in Colorado. Melanoma Res 19:252–259
Kanetsky PA, Panossian S, Elder DE et al (2010) Does MC1R genotype convey information about melanoma risk beyond risk phenotypes? Cancer 116:2416–2428
Karlsson MA, Rodvall Y, Wahlgren CF, Wiklund K, Lindelof B (2015) Similar anatomical distributions of childhood naevi and cutaneous melanoma in young adults residing in northern and southern Sweden. Eur J Cancer 51:2067–2075
Khosrotehrani K, Dasgupta P, Byrom L, Youlden DR, Baade PD, Green AC (2015) Melanoma survival is superior in females across all tumour stages but is influenced by age. Arch Dermatol Res 307:731–740
Kjems E, Krag C (1993) Melanoma and pregnancy. A review. Acta Oncol 32:371–378
Kraemer KH, Lee MM, Andrews AD, Lambert WC (1994) The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch Dermatol 130:1018–1021
Kricker A, Armstrong BK, English DR, Heenan PJ (1995) A dose–response curve for sun exposure and basal cell carcinoma. Int J Cancer 60:482–488
Lachiewicz A, Berwick M, Wiggins CL, Thomas NE (2008) Epidemiologic support for melanoma heterogeneity using the surveillance, epidemiology, and end results program. J Invest Dermatol 128:1340–1342
Lazovich D, Forster J (2005) Indoor tanning by adolescents: prevalence, practices and policies. Eur J Cancer 41:20–27
Lazovich D, Vogel RI, Berwick M, Weinstock MA, Anderson KE, Warshaw EM (2010) Indoor tanning and risk of melanoma: a case–control study in a highly exposed population. Cancer Epidemiol Biomarkers Prev 19:1557–1568
Lerro CC, Coutros S, Adreotti G, Hines CJ, Blair A, Lubin J, Ma X, LE Zhang B-F (2015) Use of acetochlor and cancer incidence in the Agricultural Health Study. Int J Cancer 137:1167–1175
Liu W, Dowling JP, Murray WK, McArthur GA, Thompson JF, Wolfe R, Kelly JW (2006) Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas. Arch Dermatol 142:1551–1558
Malagoli C, Malavolti M, Agnoli C, Crespi CM, Fiorentini CFarnetani F, Longo C, Ricci C, Albertini G, Lanzoni A, Venziano L, An V, Pagliarello C, Santini M, Fanti PA, Em D, Sieri S, Krogh V, Pellacani G, Vinceti M (2015) Diet quality and risk of melanoma in an Italian population. J Nutr 145:1800–1807
Marrett LD, Nguyen HL, Armstrong BK (2001) Trends in the incidence of cutaneous malignant melanoma in New South Wales, 1983–1996. Int J Cancer 92:457–462
Merrill SJ, Ashrafi S, Subramanian M, Godar DE (2015) Exponentially increasing incidences of cutaneous malignant melanoma in Europe correlate with low personal annual UV doses and suggests 2 major risk factors. Dermato Endocrinol 7(1): e1004018. Open access.
Miura K, Zens MS, Peart T, Holly EA, Berwick M, Gallagher RP, Mack TM, Elwood JM, Karagas MR, Green AC (2015) Alcohol consumption and risk of melanoma among women: pooled analysis of eight case–control studies. Arch Dermatol Res 307:819–828
Moan J, Dahlback A, Setlow RB (1999) Epidemiological support for an hypothesis for melanoma induction indicating a role for UVA radiation. Photochem Photobiol 70:243–247
Muller HK, Malley RC, McGee HM, Scott DK, Wozniak T, Woods GM (2008) Effect of UV radiation on the neonatal skin immune system – implications for melanoma. Photochem Photobiol 84:47–54
Murphy GM, Norris PG, Young AR, Corbett MF, Hawk JL (1993) Low-dose ultraviolet-B irradiation depletes human epidermal Langerhans cells. Br J Dermatol 129:674–677
Naidoo J, Page DB, Wolchok JD (2014) Immune modulation for cancer therapy. Br J Cancer 111:2214–2219
Nedergaard BS, Ladekarl M, Thomsen HF, Nyengaard JR, Nielsen K (2007) Low density of CD3+, CD4+ and CD8+ cells is associated with increased risk of relapse in squamous cell cervical cancer. Br J Cancer 97:1135–1138
Nelemans PJ, Rampen FHJ, Ruiter DJ, Verbeek ALM (1995) An addition to the controversy on sunlight exposure and melanoma risk: a meta-analytical approach. J Clin Epidemol 58:1331–1342
Nilsen LTN, Hannevik M, Veierod MB (2016) UV exposure from indoor tanning devices: a systematic review. Br J Dermatol 174(4):730–740
Norval M (2006) The mechanisms and consequences of ultraviolet-induced immunosuppression. Prog Biophys Mol Biol 92:108–118
Olsen CM, Neale RE, Green AC, Webb PM, QSkin Study, Epigene Study, Whiteman DC (2015) Independent validation of six melanoma risk prediction models. J Invest Dermatol 135:1377–1384
Orlow I, Roy P, Reiner AS, Yoo S, Patel H, Paine S, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Thomas NE, Gruber SB, Anton-Culver H, Rosso S, Gallgaher RP, Dwyer T, Kanetsky PA, Busam K, From L, Begg CB, Berwick M, GEM Study Group (2012) Vitamin D receptor polymorphisms in patients with cutaneous melanoma. Int J Cancer 130:405–418
Osterlind A, Engholm G, Jensen OM (1988) Trends in cutaneous malignant melanoma in Denmark 1943–1982 by anatomical site. APMIS 96:953–963
Palmer JS, Duffy DL, Box NF et al (2000) Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype? Am J Hum Genet 66:176–186
Pasquali E, Garcia-Borrón JC, Fargnoli MC, Gandini S, Maisonneuve P, Bagnardi V, Specchia C, Liu F, Kayser M, Nijsten T, Nagore E, Kumar R, Hansson J, Kanetsky PA, Ghiorzo P, Debniak T, Branicki W, Gruis NA, Han J, Dwyer T, Blizzard L, Landi MT, Palmieri G, Ribas G, Stratigos A, Council ML, Autier P, Little J, Newton-Bishop J, Sera F, Raimondi S, M-SKIP Study Group (2015) MC1R variants increase the risk of sporadic cutaneous melanoma in darker-pigmentd Caucasians: a pooled-analysis from the M-SKIP project. Int J Cancer 136:618–631
Petersen B, Thieden E, Lerche CM, Wulf HC (2013) Validation of self-reported erythema: comparison of self-reports, researcher assessment and objective measurements in sun worshippers and skiers. J Eur Acad Dermatol Venereol 27:214–219
Purdue MP, Freeman LE, Anderson WF, Tucker MA (2008) Recent trends in incidence of cutaneous melanoma among US Caucasian young adults. J Invest Dermatol 128:2905–2908
Roh MR, Eliades P, Gupta SM, Grant-Kels JM, Tsao H (2015) Cutaneous melanoma in women. Int J Womens Dermatol 1:21–25
Rossman TG, Uddin AN, Burns FJ (2004) Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198:394–404
Rosso S, Zanetti R, Martinez C, Tormo MJ, Schraub S, Sancho-Garnier H, Franceschi S, Gafa L, Perea E, Navarro C, Laurent R, Schrameck C, Talamini R, Tumino R, Wechsler J (1996) The multicentre south European study “Helios” II: different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin. Br J Cancer 73:1447–1454
Rouhani P, Pinheiro PS, Sherman R, Arheart K, Fleming LE, Mackinnon J, Kirsner RS (2010) Increasing rates of melanoma among nonwhites in Florida compared with the United States. Arch Dermatol 146:741–746
Seggato MM, Bananigo RR, Hohman CB, Müller KR, Bakos L, Matrroeni S, Fortes C (2015) Residential and occupational exposure to pesticides may increase risk for cutaneous melanoma: a case–control study conducted in the south of Brazil. Int J Dermatol 54:e527–e538
Seité S, Zucchi H, Moyal D, Tison S, Compan D, Christiaens F, Gueniche A, Fourtanier A (2003) Alterations in human epidermal Langerhans cells by ultraviolet radiation: quantitative and morphological study. Br J Dermatol 148:291–299
Shaikh WR, Dusza SW, Weinstock MA, Oliveria SA, Geller AC, Halpern AC (2016) Melanoma thickness and survival trends in the United States, 1989 to 2009. J Natl Cancer Inst 108:1–7
Sinclair CA, Makin JK, Tang A, Brozek I, Rock V (2014) The role of public health advocacy in achieving an outright ban on commercial tanning beds in Australia. Am J Public Health 104:e7–e9
Stern RS (2005) Proportion of lifetime UV dose received by age 18, what Stern et al actually said in 1986. J Invest Dermatol 124:1079–1080
Surveillance Epidemiology and End Results (SEER) Program (2009) Cancer statistics review. National Cancer Institute, Bethesda
Thiam A, Zhao Z, Quinn C, Barber B (2015) Years of life lost due to metastatic melanoma in 12 countries. J Med Econ 25:1–6
Thomas NE, Kricker A, From L, Busam KJ, Millikan RC, Ritchey ME, Armstrong BK, Lee-Taylor J, Marrett L, Anton-Culver H, Zanetti R, Rosso S, Gallagher RP, Dwyer T, Goumas C, Kanetsky PA, Begg CB, Orlow I, Wilcox H, Paine S, Berwick M (2010) Associations of cumulative sun exposure and phenotypic characteristics with histologic solar elastosis. Cancer Epidemiol Biomarkers Prev 19:2932–2941
Thomas NE, Busam KJ, From L, Kricker A, Armstrong BK, Anton-Culver H, Gruber SB, Gallagher RP, Zanetti R, Rosso S, Dwyer T, Venn A, Kanetsky PA, Groben PA, Hao H, Orlow I, Reiner AS, Luo L, Paine S, Ollila DW, Wilcox H, Begg CB, Berwick M (2014) Tumor-infiltrating lymphocyte grade in primary melanomas is independently associated with melanoma-specific survival in the population-based genes, environment and melanoma study. J Clin Oncol 31:4252–4259
Tran TT, Schulman J, Fisher DE (2008) UV and pigmentation: molecular mechanisms and social controversies. Pigment Cell Melanoma Res 21:509–516
Vajdic CM, van Leeuwen MT, Webster AC, McCredie MRE, Stewart JH, Chapman JR, Amin J, McDonald SP, Grulich AE (2009) Cutaneous melanoma is related to immune suppression in kidney transplant recipients. Cancer Epidemiol Biomarkers Prev 18:2297–2303
Veierød MB, Weiderpass E, Thörn M, Hansson J, Lund E, Armstrong B, Adami HO (2003) A prospective study of pigmentation, sun exposure, and risk of cutaneous malignant melanoma in women. J Natl Cancer Inst 95:1530–1538
Vogel RI, Ahmed RL, Nelson HH, Berwick M, Weinstock MA, Lazovich D (2014) Exposure to indoor tanning without burning and melanoma risk by sunburn history. J Natl Cancer Inst 106:dju112
Wagner JK, Parra EJ, Norton HL, Jovel C, Shriver MD (2002) Skin responses to ultraviolet radiation: effects of constitutive pigmentation, sex, and ancestry. Pigment Cell Res 15:385–390
Wang J, Li X, Zhang D (2016) Coffee consumption and the risk of cutaneous melanoma: a meta-analysis. Eur J Nutr 55(4):1317–1329
Wei Q, Lee JE, Gershenwald JE, Ross MI, Mansfield PF, Strom SS, Wang LE, Guo Z, Qiao Y, Amos CI, Spitz MR, Duvic M (2003) Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma. J Natl Cancer Inst 95:308–315
Welch HG, Black WC (2010) Overdiagnosis in cancer. J Natl Cancer Inst 102:605–613
Wester U, Boldemann C, Jansson B, Ullén H (1999) Population UV-dose and skin area – do sunbeds rival the sun? Health Phys 77:436–440
Westerdahl J, Anderson H, Olsson H, Ingvar C (1996) Reproducibility of a self-administered questionnaire for assessment of melanoma risk. Int J Epidemiol 25:245–251
White E, Kirkpatrick CS, Lee JA (1994) Case–control study of malignant melanoma in Washington State. I. Constitutional factors and sun exposure. Am J Epidemiol 139:857–868
Whiteman DC, Watt P, Purdie DM, Hughes MC, Hayward NK, Green AC (2003) Melanocytic nevi, solar keratoses and divergent pathways to cutaneous melanoma. J Natl Cancer Inst 95:806–812
Whiteman DC, Whiteman CA, Green AC (2001) Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies. Cancer Causes Control 12:69–82
Yager JW, Erdei E, Myers O, Siegel M, Berwick M (2016) Arsenic and ultraviolet radiation exposure: melanoma in a New Mexico no-Hispanic white population. Environ Geochem Health 38(3):897–910
Yamaguchi Y, Takahashi K, Zmudzka BZ, Kornhauser A, Miller SA, Tadokoro T, Berens W, Beer JZ, Hearing VJ (2006) Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. FASEB J 20(9):1486–1488
Yew YW, Lai YC, Schwartz RA (2016) Coffee consumption and melanoma: a systematic review and meta-analysis of observational studies. Am J Clin Dermatol 17(2):113–123
Acknowledgments
I acknowledge assistance with the SEER and IARC data from Angela Meisner and Dr. Charles Wiggins. This work was supported by NCI R01 CA 112425 and by the University of New Mexico Cancer Center and the University of New Mexico Department of Internal Medicine.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Berwick, M. (2017). Melanoma Epidemiology. In: Bosserhoff, A. (eds) Melanoma Development. Springer, Cham. https://doi.org/10.1007/978-3-319-41319-8_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-41319-8_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-41317-4
Online ISBN: 978-3-319-41319-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)