Skip to main content

Part of the book series: Springer Theses ((Springer Theses))

  • 499 Accesses

Abstract

Studies of fixation dynamics in Markov processes predominantly focus on the mean time to absorption. This may be inadequate if the distribution is broad and skewed. We compute the distribution of fixation times in one-step birth-death processes with two absorbing states. These are expressed in terms of the spectrum of the process, and we provide different representations as forward-only processes in eigenspace. These allow efficient sampling of fixation time distributions. As an application we study evolutionary game dynamics, where invading mutants can reach fixation or go extinct. We also highlight the median fixation time as a possible analog of mixing times in systems with small mutation rates and no absorbing states, whereas the mean fixation time has no such interpretation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    Samuel Karlin (1924–2007) and James McGregor (1921–1988).

  2. 2.

    All samples were generated on the same computer, a 2012 MacBook Air with 1.8 GHz i5 processor running OSX 10.10.4. Software used is Mathematica 9.0.1, and times were measured using the \(\texttt {AbsoluteTiming[]}\) function.

References

  1. D. Dingli, A. Traulsen, J.M. Pacheco, Stochastic dynamics of hematopoietic tumor stem cells. Cell Cycle 6, 461 (2007)

    Article  Google Scholar 

  2. P.M. Altrock, A. Traulsen, F.A. Reed, Stability properties of underdominance in finite subdivided populations. PLoS Comput. Biol. 7, e1002260 (2011)

    Article  ADS  MathSciNet  Google Scholar 

  3. P. Ashcroft, A. Traulsen, T. Galla, When the mean is not enough: calculating fixation time distributions in birth-death processes. Phys. Rev. E 92, 042154 (2015)

    Article  ADS  Google Scholar 

  4. N. Goel, N. Richter-Dyn, Stochastic Models in Biology (Academic Press, New York, 1974)

    Google Scholar 

  5. W.J. Ewens, Mathematical Population Genetics. I. Theoretical Introduction (Springer, New York, 2004)

    Book  MATH  Google Scholar 

  6. S. Karlin, J. McGregor, Coincidence properties of birth and death processes. Pacific J. Math 9, 1109 (1959)

    Article  MathSciNet  MATH  Google Scholar 

  7. J. Keilson, Markov Chain Models: Rarity and Exponentiality (Springer, New York, 1979)

    Book  MATH  Google Scholar 

  8. M. Brown, Y.-S. Shao, Identifying coefficients in the spectral representation for first passage time distributions. Probab. Eng. Inform. Sc. 1, 69 (1987)

    Article  MATH  Google Scholar 

  9. J.A. Fill, Time to stationarity for a continuous-time markov chain. Probab. Eng. Inform. Sc. 5, 61 (1991)

    Article  MathSciNet  MATH  Google Scholar 

  10. M. Brown, Interlacing eigenvalues in time reversible markov chains. Math. Oper. Res. 24, 847 (1999)

    Article  MathSciNet  MATH  Google Scholar 

  11. J.A. Fill, The passage time distribution for a birth-and-death chain: strong stationary duality gives a first stochastic proof. J. Theoret. Probab. 22, 543 (2009)

    Article  MathSciNet  MATH  Google Scholar 

  12. P. Diaconis, L. Miclo, On times to quasi-stationarity for birth and death processes. J. Theoret. Probab. 22, 558 (2009)

    Article  MathSciNet  MATH  Google Scholar 

  13. J.A. Fill, On hitting times and fastest strong stationary times for skip-free and more general chains. J. Theoret. Probab. 22, 587 (2009)

    Article  MathSciNet  MATH  Google Scholar 

  14. L. Miclo, On absorption times and dirichlet eigenvalues. ESAIM Probab. Stat. 14, 117 (2010)

    Article  MathSciNet  MATH  Google Scholar 

  15. Y. Gong, Y.-H. Mao, C. Zhang, Hitting time distributions for denumerable birth and death processes. J. Theoret. Probab. 25, 950 (2012)

    Article  MathSciNet  MATH  Google Scholar 

  16. M. Barrio, A. Leier, T.T. Marquez-Lago, Reduction of chemical reaction networks through delay distributions. J. Chem. Phys. 138, 104114 (2013)

    Article  ADS  Google Scholar 

  17. A. Leier, M. Barrio, T.T. Marquez-Lago, Exact model reduction with delays: Closed-form distributions and extensions to fully bi-directional monomolecular reactions. J. R. Soc. Interface 11, 20140108 (2014)

    Article  Google Scholar 

  18. H. Risken, The Fokker-Planck Equation (Springer, Berlin, 1989)

    Book  MATH  Google Scholar 

  19. T. Antal, I. Scheuring, Fixation of strategies for an evolutionary game in finite populations. Bull. Math. Biol. 68, 1923 (2006)

    Article  MathSciNet  MATH  Google Scholar 

  20. C. Taylor, Y. Iwasa, M.A. Nowak, A symmetry of fixation times in evolutionary dynamics. J. Theor. Biol. 243, 245 (2006)

    Article  MathSciNet  Google Scholar 

  21. D.T. Gillespie, Exact stochastic simulation of coupled chemical reactions. J. Phys. Chem. 81, 2340 (1977)

    Article  Google Scholar 

  22. D.A. Levin, Y. Peres, E.L. Wilmer, Markov Chains and Mixing Times (AMS Publishing, Providence RI, 2009)

    MATH  Google Scholar 

  23. A.J. Black, A. Traulsen, T. Galla, Mixing times in evolutionary games. Phys. Rev. Lett. 109, 028101 (2012)

    Article  ADS  Google Scholar 

  24. W.H. Press, S.A. Teukolsky, W.T. Vetterling, B.P. Flannery, Numerical Recipes: The Art of Scientific Computing (Cambridge University Press, Cambridge UK, 2007)

    MATH  Google Scholar 

  25. M.A. Nowak, Evolutionary Dynamics (Harvard University Press, Cambridge MA, 2006)

    MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Peter Ashcroft .

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Ashcroft, P. (2016). Fixation Time Distributions in Birth–Death Processes. In: The Statistical Physics of Fixation and Equilibration in Individual-Based Models. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-41213-9_4

Download citation

Publish with us

Policies and ethics