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Stem Cell Therapy for Avascular Femoral Head Necrosis: From Preclinical to Clinical Study

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Bone and Cartilage Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

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Abstract

Avascular necrosis of the femoral head (AVNFH) is a condition involving low blood supply to the femoral head. Lacking blood, the femoral head degenerates. Although there are certain techniques to treat this disease, the treatment efficiency does not significantly improve the symptoms, especially in the late stage of AVNFH. Currently, AVNFH is treated with stem cells. Various sources of stem cells, such as bone marrow- and adipose tissue-derived stem cells, have been applied with promising results. This chapter reviews and summarizes some of the results of AVNFH treatment by stem cell transplantation from preclinical study to the clinic.

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Abbreviations

ADSCs:

Adipose-derived stem cells

AVNFH:

Avascular necrosis of the femoral head

BM:

Bone marrow

BMMNCs:

Bone marrow mononuclear cells

BMMSCs:

Bone marrow mesenchymal stem cells

BMP:

Bone morphogenetic protein

cBMMNC:

Cryopreserved bone marrow mononuclear cells

CT:

Computed tomography

EPCs:

Endothelial progenitor cells

HGF:

Hepatocyte growth factor

hIDPSC:

Human immature dental pulp stem cells

HIF-1α:

Hypoxia-inducible factor-1α

MRI:

Magnetic resonance imaging

MSCs:

Mesenchymal stem cells

PBSC:

Peripheral blood stem cells

SCPP:

Strontium-doped calcium polyphosphate

TCP:

Tricalcium phosphate

THA:

Total hip arthroplasty

UC-MSCs:

Umbilical cord mesenchymal stem cells

VAS:

Visual analogue scale

VEGF:

Vascular endothelial growth factor

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Acknowledgment

This work was funded by the Ministry of Science and Technology under grant number DM.10.DA/15.

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  1. Laboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham & Ngoc Bich Vu

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  1. Phuc Van Pham
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Correspondence to Phuc Van Pham .

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  1. Laboratory of Stem Cell Research and Application, University of Science Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Van Pham, P., Vu, N.B. (2016). Stem Cell Therapy for Avascular Femoral Head Necrosis: From Preclinical to Clinical Study. In: Pham, P. (eds) Bone and Cartilage Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-40144-7_5

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