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Stem Cell Therapy for the Treatment of Cartilage Defects and Osteoarthritis

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Bone and Cartilage Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

Abstract

Cartilage defects (CDs) and osteoarthritis (OA) are notorious for their reluctance to current therapeutic measures. Pathogenic mechanisms, onset, and severity of cartilage diseases are largely variable; however, they share the common trait of increased incidence and prevalence. Stem cell therapies are new therapeutic tools that could lead to complete structural and functional cartilage regeneration. Basic, preclinical, and clinical research using different types of stem cell population are available, showing promising preliminary results. For reasons such as availability, relatively simple processing steps, and clearance of ethical concerns, mesenchymal stem cells (MSCs) appear to be the source that has already made its way to clinical settings. Case reports, several results from different phase clinical trials as well as a couple of pertinent meta analyses are available, pointing towards an increased interest in the field in both scientific as well as clinical practice. This chapter will briefly describe type and epidemiology of CD and OA, further introducing MSC treatment as a concept as well as facts about the therapeutic opportunity with a focus on already published results from case series and clinical trials.

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Acknowledgements

Authors thank Dr. Cionca Dan for providing the arthroscopic images and for the logistic support.

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Authors and Affiliations

  1. Faculty of Health and Medical Sciences, Department of Veterinary Clinical and Animal Sciences, Section for Anatomy, Biochemistry, University of Copenhagen, Grønnegårdsvej, 71870, Frederiksberg C, Denmark

    Luminita Labusca & Florin Zugun-Eloae

  2. Orthopedic and Traumatology Clinic, Emergency University Hospital Saint Spiridon, Piaṭa Independenṭei 1, Iasi, 700111, Romania

    Luminita Labusca & Florin Zugun-Eloae

  3. National Institute of Research and Development for Technical Physics, 47 Mangeron Blvd., 833, P.O. 3, RO-700050, Iasi, Romania

    Luminita Labusca & Florin Zugun-Eloae

  4. Department of Molecular Genetics and Immunology, Gr.T.Popa: University of Medicine and Pharmacy Iasi, 16 Universitatii Street, 700000, Iasi, Romania

    Luminita Labusca & Florin Zugun-Eloae

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  1. Luminita Labusca
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  2. Florin Zugun-Eloae
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Correspondence to Luminita Labusca .

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  1. Laboratory of Stem Cell Research and Application, University of Science Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Labusca, L., Zugun-Eloae, F. (2016). Stem Cell Therapy for the Treatment of Cartilage Defects and Osteoarthritis. In: Pham, P. (eds) Bone and Cartilage Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-40144-7_2

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