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Tissue Engineering Approaches for Rotator Cuff Repair

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Bone and Cartilage Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

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Abstract

Rotator cuff tears follow three main patterns. They may be the result of a traumatic tear in a young healthy patient, a traumatic tear in the old degenerate tendon, or result from an atraumatic degenerate tear, again in the older patient. Both intrinsic and extrinsic factors contribute to tears. Those who are particularly at risk partake in overhead activities and overuse their rotator cuff.

Treating acute tears surgically is now common practice. Arthroscopic surgery is most commonly employed and has very good results. Difficulties are however encountered in the degenerate tendons, and massive tears which may be deemed irrepairable.

Tissue engineering has developed significantly in this field, and this chapter aims to highlight the differing therapies, which have been developed. These include gene therapy, cell therapy, engineering of both biological and non-biological scaffolds and use of growth factors. Results have shown promise in animal models, but few human clinical trials have offered groundbreaking changes.

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Authors and Affiliations

  1. Department of Trauma & Orthopaedics, Barts Health NHS Trust, The Royal London Hospital, Whitechapel, London, E1 1BB, UK

    Nick Aresti

  2. Division of Trauma and Orthopaedics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CB2 2QQ, UK

    Wasim S. Khan

  3. Department of Trauma and Orthopaedics, Buckinghamshire NHS Trust, Stoke Mandeville Hospital, Aylesbury, HP21 8BD, UK

    Atif A. Malik

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  1. Nick Aresti
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  2. Wasim S. Khan
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  3. Atif A. Malik
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Correspondence to Atif A. Malik .

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Editors and Affiliations

  1. Laboratory of Stem Cell Research and Application, University of Science Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Aresti, N., Khan, W.S., Malik, A.A. (2016). Tissue Engineering Approaches for Rotator Cuff Repair. In: Pham, P. (eds) Bone and Cartilage Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-40144-7_13

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