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Efficacy of Renal Denervation on Blood Pressure Reduction

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Interventional Therapies for Secondary and Essential Hypertension

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

Increased renal sympathetic activity plays a dominant role in the pathogenesis of hypertension and along with the unmet needs for improving the rate of controlled hypertension provides the rationale for renal nerve ablation. Renal denervation has demonstrated a significant reduction in unblinded studies of resistant hypertensive studies, but HTN-3, the first randomized trial of renal denervation versus sham control, failed its primary efficacy end point. Subanalysis of HTN-3 generated many questions for potentially confounding factors related to procedural aspects, drug changes and adherence, and the study population. New studies have been designed to overcome the limitations associated with previous renal denervation studies and definitely answer the question about the renal denervation efficacy on blood pressure reduction.

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Abbreviations

BP:

Blood pressure

dRHTN:

Drug-resistant HTN

HTN:

Hypertension

RDN:

Renal denervation

SHR:

Spontaneously hypertensive rats

SNS:

Sympathetic nervous system

SSAHT:

Standardized stepped-care antihypertensive treatment

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Authors and Affiliations

  1. 1st Cardiology Clinic, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece

    Costas P. Tsioufis & Dimitrios Tousoulis

Authors
  1. Costas P. Tsioufis
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  2. Dimitrios Tousoulis
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Correspondence to Costas P. Tsioufis .

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Editors and Affiliations

  1. First Cardiology Clinic, National and Kapodistrian University of Athens, Athens, Greece

    Costas Tsioufis

  2. Department of Nephrology and Hypertension, University Hospital Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

    Roland E. Schmieder

  3. IRCCS Istituto Auxologico Italiano, University Milano-Bicocca, Milano Monza, Italy

    Giuseppe Mancia

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Tsioufis, C.P., Tousoulis, D. (2016). Efficacy of Renal Denervation on Blood Pressure Reduction. In: Tsioufis, C., Schmieder, R., Mancia, G. (eds) Interventional Therapies for Secondary and Essential Hypertension. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-34141-5_16

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  • DOI: https://doi.org/10.1007/978-3-319-34141-5_16

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