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Procedural Aspects of Renal Sympathetic Denervation

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Interventional Therapies for Secondary and Essential Hypertension

Abstract

Renal sympathetic denervation (RDN) has, until recently, been a black box procedure, driven by incomplete knowledge on the anatomy of the sympathetic nervous system. In recent years, several procedural advancements have been made. The distribution of sympathetic nerves in the relation to the renal arteries has been further analyzed. The impact of different lesion sites, lesion numbers, and patterns has been evaluated. The spectrum of denervation techniques and systems has been expanded and adjusted according to new anatomical findings. In addition, possibilities of intra-procedural efficacy evaluation are being developed. The following chapter summarizes our current knowledge and recent developments on procedural aspects of renal denervation. It then outlines steps prior, during, and post procedure with instructions on the commercially available renal denervation systems.

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Abbreviations

BP:

Blood pressure

HTN:

Hypertension

RDN:

Renal denervation

References

  1. Ozkan U, Oguzkurt L, Tercan F, Kizilkilic O, Koc Z, Koca N (2006) Renal artery origins and variations: angiographic evaluation of 855 consecutive patients. Diagn Interv Radiol 12(4):183–186

    PubMed  Google Scholar 

  2. Turba UC, Uflacker R, Bozlar U, Hagspiel KD (2009) Normal renal arterial anatomy assessed by multidetector CT angiography: are there differences between men and women? Clin Anat 22(2):236–242. doi:10.1002/ca.20748

    Article  PubMed  Google Scholar 

  3. Manso JC, DiDio LJ (2000) Anatomical variations of the human suprarenal arteries. Ann Anat 182(5):483–488. doi:10.1016/S0940-9602(00)80064-3

    Article  CAS  PubMed  Google Scholar 

  4. Tsioufis C, Mahfoud F, Mancia G, Redon J, Damascelli B, Zeller T, Schmieder RE (2014) What the interventionalist should know about renal denervation in hypertensive patients: a position paper by the ESH WG on the interventional treatment of hypertension. EuroIntervention 9(9):1027–1035. doi:10.4244/EIJV9I9A175

    Article  PubMed  Google Scholar 

  5. Esler M (2015) The sympathetic nervous system in hypertension: back to the future? Curr Hypertens Rep 17(2):11. doi:10.1007/s11906-014-0519-8

    Article  PubMed  Google Scholar 

  6. Tellez A, Rousselle S, Palmieri T, Rate WR, Wicks J, Degrange A, Hyon CM, Gongora CA, Hart R, Grundy W, Kaluza GL, Granada JF (2013) Renal artery nerve distribution and density in the porcine model: biologic implications for the development of radiofrequency ablation therapies. Transl Res 162(6):381–389. doi:10.1016/j.trsl.2013.07.002

    Article  PubMed  Google Scholar 

  7. Atherton DS, Deep NL, Mendelsohn FO (2012) Micro-anatomy of the renal sympathetic nervous system: a human postmortem histologic study. Clin Anat 25(5):628–633. doi:10.1002/ca.21280

    Article  PubMed  Google Scholar 

  8. Sakakura K, Ladich E, Cheng Q, Otsuka F, Yahagi K, Fowler DR, Kolodgie FD, Virmani R, Joner M (2014) Anatomic assessment of sympathetic peri-arterial renal nerves in man. J Am Coll Cardiol 64(7):635–643. doi:10.1016/j.jacc.2014.03.059

    Article  PubMed  Google Scholar 

  9. Mahfoud F, Edelman ER, Böhm M (2014) Catheter-based renal denervation is no simple matter: lessons to be learned from our anatomy? J Am Coll Cardiol 64(7):644–646. doi:10.1016/j.jacc.2014.05.037

    Google Scholar 

  10. Mahfoud F, Tunev S, Ewen S, Cremers B, Ruwart J, Schulz-Jander D, Linz D, Davies J, Kandzari DE, Whitbourn R, Böhm M, Melder RJ (2015) Impact of lesion placement on efficacy and safety of catheter-based radiofrequency renal denervation. J Am Coll Cardiol 66(16):1766–1775. doi:10.1016/j.jacc.2015.08.018

    Google Scholar 

  11. Tzafriri AR, Mahfoud F, Keating JH, Markham PM, Spognardi A, Wong G, Fuimaono K, Böhm M, Edelman ER (2014) Innervation patterns may limit response to endovascular renal denervation. J Am Coll Cardiol 64(11):1079–1087. doi:10.1016/j.jacc.2014.07.937

    Google Scholar 

  12. Kandzari DE, Bhatt DL, Brar S, Devireddy CM, Esler M, Fahy M, Flack JM, Katzen BT, Lea J, Lee DP, Leon MB, Ma A, Massaro J, Mauri L, Oparil S et al (2015) Predictors of blood pressure response in the SYMPLICITY HTN-3 trial. Eur Heart J 36(4):219–227. doi:10.1093/eurheartj/ehu441

    Article  PubMed  Google Scholar 

  13. Rosa J, Widimsky P, Tousek P, Petrak O, Curila K, Waldauf P, Bednar F, Zelinka T, Holaj R, Strauch B, Somloova Z, Taborsky M, Vaclavik J, Kocianova E, Branny M et al (2015) Randomized comparison of renal denervation versus intensified pharmacotherapy including spironolactone in true-resistant hypertension: six-month results from the Prague-15 study. Hypertension 65(2):407–413. doi:10.1161/HYPERTENSIONAHA.114.04019

    Article  CAS  PubMed  Google Scholar 

  14. Schmid A, Ditting T, Sobotka PA, Veelken R, Schmieder RE, Uder M, Ott C (2013) Does renal artery supply indicate treatment success of renal denervation? Cardiovasc Intervent Radiol 36(4):987–991. doi:10.1007/s00270-013-0652-9

    Article  PubMed  Google Scholar 

  15. Id D, Kaltenbach B, Bertog SC, Hornung M, Hofmann I, Vaskelyte L, Sievert H (2013) Does the presence of accessory renal arteries affect the efficacy of renal denervation? JACC Cardiovasc Interv 6(10):1085–1091. doi:10.1016/j.jcin.2013.06.007

    Article  PubMed  Google Scholar 

  16. Kandzari DE, Kario K, Mahfoud F, Cohen SA, Pilcher G, Pocock S, Townsend R, Weber MA, Böhm M (2016) The SPYRAL HTN global clinical trial program: rationale and design for studies of renal denervation in the absence (SPYRAL HTN OFF-MED) and presence (SPYRAL HTN ON-MED) of antihypertensive medications. Am Heart J 171(1):82–91. doi:10.1016/j.ahj.2015.08.021

    Google Scholar 

  17. Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham WT, Esler M (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373(9671):1275–1281. doi:10.1016/S0140-6736(09)60566-3

    Article  PubMed  Google Scholar 

  18. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Böhm M (2010) Renal sympathetic denervation in patients with treatment-resistant hypertension (the symplicity HTN-2 trial): a randomised controlled trial. Lancet 376(9756):1903–1909. doi:10.1016/S0140-6736(10)62039-9

  19. Bhatt DL, Kandzari DE, O’Neill WW, D’Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, Cohen SA, Oparil S, Rocha-Singh K, Townsend RR, Bakris GL et al (2014) A controlled trial of renal denervation for resistant hypertension. N Engl J Med 370(15):1393–1401. doi:10.1056/NEJMoa1402670

    Article  CAS  PubMed  Google Scholar 

  20. Patel HC, Dhillon PS, Mahfoud F, Lindsay AC, Hayward C, Ernst S, Lyon AR, Rosen SD, di Mario C (2014) The biophysics of renal sympathetic denervation using radiofrequency energy. Clin Res Cardiol 103(5):337–344. doi:10.1007/s00392-013-0618-6

    Article  PubMed  Google Scholar 

  21. Worthley SG, Tsioufis CP, Worthley MI, Sinhal A, Chew DP, Meredith IT, Malaiapan Y, Papademetriou V (2013) Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial. Eur Heart J 34(28):2132–2140. doi:10.1093/eurheartj/eht197

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Pathak A, Coleman L, Roth A, Stanley J, Bailey L, Markham P, Ewen S, Morel C, Despas F, Honton B, Senard JM, Fajadet J, Mahfoud F (2015) Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity. EuroIntervention 11(4):477–484. doi:10.4244/EIJV11I4A96

    Article  PubMed  Google Scholar 

  23. Gertner M, Crura F, Zhang J (2015) Renal denervation using externally delivered focused ultrasound: summary of clinical experience to date and validation of supporting computational simulations. J Ther Ultrasound 3(Suppl 1):O68. doi:10.1186/2050-5736-3-S1-O68

    Article  PubMed Central  Google Scholar 

  24. Fischell TA, Fischell DR, Ghazarossian VE, Vega F, Ebner A (2015) Next generation renal denervation: chemical “perivascular” renal denervation with alcohol using a novel drug infusion catheter. Cardiovasc Revasc Med 16(4):221–227. doi:10.1016/j.carrev.2015.04.008

    Article  PubMed  Google Scholar 

  25. Schlaich MP, Schmieder RE, Bakris G, Blankestijn PJ, Böhm M, Campese VM, Francis DP, Grassi G, Hering D, Katholi R, Kjeldsen S, Krum H, Mahfoud F, Mancia G, Messerli FH et al (2013) International expert consensus statement: percutaneous transluminal renal denervation for the treatment of resistant hypertension. J Am Coll Cardiol 62(22):2031–2045. doi:10.1016/j.jacc.2013.08.1616

    Google Scholar 

  26. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE et al (2013) 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 34(28):2159–2219. doi:10.1093/eurheartj/eht151

  27. Persu A, Jin Y, Baelen M, Vink E, Verloop WL, Schmidt B, Blicher MK, Severino F, Wuerzner G, Taylor A, Pechere-Bertschi A, Jokhaji F, Fadl Elmula FE, Rosa J, Czarnecka D et al (2014) Eligibility for renal denervation: experience at 11 European expert centers. Hypertension 63(6):1319–1325. doi:10.1161/HYPERTENSIONAHA.114.03194

    Article  CAS  PubMed  Google Scholar 

  28. Böhm M, Mahfoud F, Ukena C, Hoppe UC, Narkiewicz K, Negoita M, Ruilope L, Schlaich MP, Schmieder RE, Whitbourn R, Williams B, Zeymer U, Zirlik A, Mancia G, Investigators GSR (2015) First report of the Global SYMPLICITY Registry on the effect of renal artery denervation in patients with uncontrolled hypertension. Hypertension 65(4):766–774. doi:10.1161/HYPERTENSIONAHA.114.05010

    Article  PubMed  Google Scholar 

  29. Desch S, Okon T, Heinemann D, Kulle K, Rohnert K, Sonnabend M, Petzold M, Muller U, Schuler G, Eitel I, Thiele H, Lurz P (2015) Randomized sham-controlled trial of renal sympathetic denervation in mild resistant hypertension. Hypertension 65(6):1202–1208. doi:10.1161/HYPERTENSIONAHA.115.05283

    Article  CAS  PubMed  Google Scholar 

  30. Azizi M, Sapoval M, Gosse P, Monge M, Bobrie G, Delsart P, Midulla M, Mounier-Vehier C, Courand PY, Lantelme P, Denolle T, Dourmap-Collas C, Trillaud H, Pereira H, Plouin PF et al (2015) Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial. Lancet 385(9981):1957–1965. doi:10.1016/S0140-6736(14)61942-5

    Article  PubMed  Google Scholar 

  31. Ott C, Mahfoud F, Schmid A, Toennes SW, Ewen S, Ditting T, Veelken R, Ukena C, Uder M, Böhm M, Schmieder RE (2015) Renal denervation preserves renal function in patients with chronic kidney disease and resistant hypertension. J Hypertens 33(6):1261–1266. doi:10.1097/HJH.0000000000000556

    Google Scholar 

  32. Ribichini F, Ferrara A, Pighi M, Pesarini G, Gambaro A, Valvo E, Lupo A, Vassanelli C (2014) Single-side renal sympathetic denervation to treat malignant refractory hypertension in a solitary kidney patient. J Nephrol. doi:10.1007/s40620-014-0059-y

    Google Scholar 

  33. Rountas C, Vlychou M, Vassiou K, Liakopoulos V, Kapsalaki E, Koukoulis G, Fezoulidis IV, Stefanidis I (2007) Imaging modalities for renal artery stenosis in suspected renovascular hypertension: prospective intraindividual comparison of color Doppler US, CT angiography, GD-enhanced MR angiography, and digital substraction angiography. Ren Fail 29(3):295–302. doi:10.1080/08860220601166305

    Article  CAS  PubMed  Google Scholar 

  34. Mahfoud F, Tunev S, Ruwart J, Schulz-Jander D, Cremers B, Linz D, Zeller T, Bhatt DL, Rocha-Singh K, Böhm M, Melder RJ (2014) Efficacy and safety of catheter-based radiofrequency renal denervation in stented renal arteries. Circ Cardiovasc Interv 7(6):813–820. doi:10.1161/CIRCINTERVENTIONS.114.001506

    Google Scholar 

  35. Ziegler AK, Franke J, Bertog SC (2013) Renal denervation in a patient with prior renal artery stenting. Catheter Cardiovasc Interv 81(2):342–345. doi:10.1002/ccd.24507

    Article  PubMed  Google Scholar 

  36. Templin C, Jaguszewski M, Ghadri JR, Sudano I, Gaehwiler R, Hellermann JP, Schoenenberger-Berzins R, Landmesser U, Erne P, Noll G, Luscher TF (2013) Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity catheter system and the EnligHTN multi-electrode renal denervation catheter. Eur Heart J 34(28):2141–2148, 2148b. doi:10.1093/eurheartj/eht141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Chinushi M, Izumi D, Iijima K, Suzuki K, Furushima H, Saitoh O, Furuta Y, Aizawa Y, Iwafuchi M (2013) Blood pressure and autonomic responses to electrical stimulation of the renal arterial nerves before and after ablation of the renal artery. Hypertension 61(2):450–456. doi:10.1161/HYPERTENSIONAHA.111.00095

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Felix Mahfoud MD, FESC .

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Zivanovic, I., Ewen, S., Böhm, M., Mahfoud, F. (2016). Procedural Aspects of Renal Sympathetic Denervation. In: Tsioufis, C., Schmieder, R., Mancia, G. (eds) Interventional Therapies for Secondary and Essential Hypertension. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-34141-5_14

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  • DOI: https://doi.org/10.1007/978-3-319-34141-5_14

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