Abstract
This paper presents a new envisaged micro-rheometer device based on a Lab-on-a-Chip solution, focused to biomedical applications with small volume of sample (less than 50 µL). Based on capturing the fluids velocity along a microchannel, this novel device presents great advantages over products already on the market for measuring the fluid viscosity, ranging from the cost to the simplicity of operation. The presented device has the capability to extract the viscosity of any type of fluid with a microdevice manufactured with PDMS (polydimethylsiloxane) and electrodes screen-printed over a PET (polyethylene terephthalate) surface. In the present work Newtonian fluids, such as water and ethylene glycol at different concentrations, have been used to calibrate the device, and non-Newtonian fluids such as blood has been employed to test it. We have observed in our initial experiments the predictable Newtonian behavior in the case of water and ethylene glycol and with blood, the non-Newtonian nature of the sample. Analyzing the results, the precision and accuracy of the device has been validated obtaining values of viscosity, with the presented set-up, which differ from those in the literature by a 10%.
The original version of this chapter was inadvertently published with an incorrect chapter pagination 451–455 and DOI 10.1007/978-3-319-32703-7_88. The page range and the DOI has been re-assigned. The correct page range is 457–461 and the DOI is 10.1007/978-3-319-32703-7_89. The erratum to this chapter is available at DOI: 10.1007/978-3-319-32703-7_260
An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-32703-7_260
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
St John A. The Evidence to Support Point-of-Care Testing. The Clinical Biochemist Reviews. 2010; 31(3):111-119.
Labcompare at http://www.labcompare.com/Clinical-Diagnostics/5096-POC-Diagnostic-Devices/
Evans PA, Hawkins K, Lawrence M, Williams RL, Barrow MS, Thirumalai N, Williams PR. Rheometry and associated techniques for blood coagulation studies. Medical engineering & physics. 2008; 30(6), 671-679.
Shander A, Gross I, Hill S, Javidroozi M, Sledge S. A new perspective on best transfusion practices. Blood Transfusion. 2013; 11(2):193-202. doi:10.2450/2012.0195-12.
Ochoa B, Kruspe T, Goodbread J. A New Sensor for Viscosity and Fluid Density Measurement for Oil Well Drilling Applications. Sensors and Measuring Systems 2014; 17. ITG/GMA Symposium; Proceedings of (pp. 1-6). VDE.
Kažys R, Rekuvienė R. Viscosity and density measurement methods for polymer melts. Ultragarsas “Ultrasound”. 2012; 66(4), 20-25.
Cao Y, Liu Z, Gao X, Yu J, Hu Z, Liang Z. Dynamic Rheological Studies of Poly(p-phenyleneterephthalamide) and Carbon Nanotube Blends in Sulfuric Acid. International Journal of Molecular Sciences. 2010;11(4):1352-1364.
Chen SM, Fan CC, Chiue MS, Chou C, Chen JH, Hseu RS. Hemodynamic and Neuropathological Analysis in Rats with Aluminum Trichloride-Induced Alzheimer’s Disease. Sensi SL, ed. PLoS ONE. 2013;8(12):e82561.
Zell ZA, Nowbahar A, Mansard V, et al. Surface shear inviscidity of soluble surfactants. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(10):3677-3682.
Charles Coulomb Laboratoire at http://www.coulomb.univ-montp2.fr/perso/instrumentation/Presentation_Appareils/Instruments/Rheometer/Rheometric_fluids_spectrometer_RFS_II.html
Malvern at http://www.anamet.cz/sites/all/storage/school_of_rheology_part_1_rotational.pdf
Christopher GF, Yoo JM, Dagalakis N, Hudson SD, Migler KB. Development of a MEMS based dynamic rheometer. Lab on a chip. 2010;10(20):2749-2757.
Hudson SD, Sarangapani P, Pathak JA, Migler KB. A microliter capillary rheometer for characterization of protein solutions. Journal of pharmaceutical sciences. 2015;104(2):678-685.
Namgung B, Ng YC, Nam J, Leo HL, Kim S. Alteration of Blood Flow in a Venular Network by Infusion of Dextran 500: Evaluation with a Laser Speckle Contrast Imaging System. Connes P, ed. PLoS ONE. 2015;10(10):e0140038.
Engineeringtool box at http://www.engineeringtoolbox.com/ethylene-glycol-d_146.html
Method, apparatus and micro-rheometer for measuring rheological properties of Newtonian and non-Newtonian fluids (No. EP 15382248.1).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this paper
Cite this paper
Ortega Tañá, L., Cid, J., Rodríguez Villarreal, A.I., Colomer-Farrarons, J., Miribel-Català, P.L. (2016). Design and Implementation of a Micro-rheometer for POC Applications. In: Kyriacou, E., Christofides, S., Pattichis, C. (eds) XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. IFMBE Proceedings, vol 57. Springer, Cham. https://doi.org/10.1007/978-3-319-32703-7_89
Download citation
DOI: https://doi.org/10.1007/978-3-319-32703-7_89
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-32701-3
Online ISBN: 978-3-319-32703-7
eBook Packages: EngineeringEngineering (R0)