Abstract
Prescription drug abuse in the USA claims over 16,000 lives annually. The risk of overdose is real, and most deaths are unintentional. Multiple risk factors exist independent of the medication used (medical and psychiatric comorbidities). Treatment of opioid overdose can be accomplished with nasal or injectable naloxone. Laypersons can be trained to recognize opioid overdose and treat it immediately; however, emergency responders should be called immediately upon a witnessed overdose (911) and appropriate medical care provided at a facility.
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References
Kochanek K, et al. National vital statistics report 2011. CDC vital signs. Prescription painkiller overdoses. Use and abuse of methadone as a painkiller. 2012;60:1–117.
Warner M, et al. Drug poisoning deaths in the United States, 1980–2008. NCHS data brief. Hyattsville MD: National Center for Health Statistics. 2011;81.
Clark et al. A systematic review of community opioid overdose prevention and naloxone distribution programs. J Addict Med. 2014;8(3).
Project Lazarus. http://projectlazarus.org/.
Bohnert A, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA. 2011;305:1315–1321.
Paulozzi LJ, Logan JE, Hall AJ, McKinstry E, Kaplan JA, Crosby AE. A comparison of drug overdose deaths involving methadone and other opioid analgesics in West Virginia. Addiction (Abingdon, England). 2009;104:1541–1548.
Green TC, Grau LE, Carver HW, Kinzly M, Heimer R. Epidemiologic trends and geographic patterns of fatal opioid intoxications in Connecticut, USA: 1997–2007. Drug Alcohol Depend. 2011;115:221–8.
Dunn K, et al. Opioid prescriptions for chronic pain and overdose. Ann Intern Med. 2010;152:85–92.
Burrows D, et al. A fatal drug interaction between oxycodone and clonazepam. J Forensic Sci. 2003;48:683–6.
Zedler B, Xie L, Wang L, Joyce A, Vick C, Brigham Rands J, Kariburyo F, Baser O, Murrelle L. Risk factors for serious prescription opioid-related toxicity or overdose among veterans health administration patients. Pain Med. 2014.
Ruan X, et al. Respiratory failure following delayed intrathecal morphine pump refill: a valuable, but costly lesson. Pain Physician. 2010;13(4):337–41.
Coffey RJ, et al. Mortality associated with implantation and management of intrathecal opioid drug infusion systems to treat noncancer pain. Anesthesiology. 2009;111(4).
Jumbelic M. Deaths with transdermal fentanyl patches. Am J Forensic Med Pathol. 2010;31:18–21.
Zedler B, Xie L, Wang L, Joyce A, Vick C, Brigham Rands J, Kariburyo F, Baser O, Murrelle L. Risk factors for serious prescription opioid-related toxicity or overdose among veterans health administration patients. Pain Med. 2014.
Substance Abuse and Mental Health Services Administration. SAMHSA opioid overdose prevention toolkit. HHS Publication No. (SMA) 14–4742. Rockville MD: Substance Abuse and Mental Health Services Administration. 2014.
Wolfe TR. Bernstone T intranasal drug delivery: An alternative to intravenous administration in selected emergency cases. J Emerg Nurs. 2004;30(2):141–7.
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Silverman, S.M., Staats, P.S. (2016). Naloxone Treatment of Opioid Overdose. In: Staats, P., Silverman, S. (eds) Controlled Substance Management in Chronic Pain. Springer, Cham. https://doi.org/10.1007/978-3-319-30964-4_11
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DOI: https://doi.org/10.1007/978-3-319-30964-4_11
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