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Naloxone Treatment of Opioid Overdose

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Controlled Substance Management in Chronic Pain

Abstract

Prescription drug abuse in the USA claims over 16,000 lives annually. The risk of overdose is real, and most deaths are unintentional. Multiple risk factors exist independent of the medication used (medical and psychiatric comorbidities). Treatment of opioid overdose can be accomplished with nasal or injectable naloxone. Laypersons can be trained to recognize opioid overdose and treat it immediately; however, emergency responders should be called immediately upon a witnessed overdose (911) and appropriate medical care provided at a facility.

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References

  1. Kochanek K, et al. National vital statistics report 2011. CDC vital signs. Prescription painkiller overdoses. Use and abuse of methadone as a painkiller. 2012;60:1–117.

    Google Scholar 

  2. Warner M, et al. Drug poisoning deaths in the United States, 1980–2008. NCHS data brief. Hyattsville MD: National Center for Health Statistics. 2011;81.

    Google Scholar 

  3. www.cdc.gov/homeandrecreationalsafety/rxbrief.

  4. Clark et al. A systematic review of community opioid overdose prevention and naloxone distribution programs. J Addict Med. 2014;8(3).

    Google Scholar 

  5. Project Lazarus. http://projectlazarus.org/.

  6. Bohnert A, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA. 2011;305:1315–1321.

    Google Scholar 

  7. Paulozzi LJ, Logan JE, Hall AJ, McKinstry E, Kaplan JA, Crosby AE. A comparison of drug overdose deaths involving methadone and other opioid analgesics in West Virginia. Addiction (Abingdon, England). 2009;104:1541–1548.

    Google Scholar 

  8. Green TC, Grau LE, Carver HW, Kinzly M, Heimer R. Epidemiologic trends and geographic patterns of fatal opioid intoxications in Connecticut, USA: 1997–2007. Drug Alcohol Depend. 2011;115:221–8.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Dunn K, et al. Opioid prescriptions for chronic pain and overdose. Ann Intern Med. 2010;152:85–92.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Burrows D, et al. A fatal drug interaction between oxycodone and clonazepam. J Forensic Sci. 2003;48:683–6.

    PubMed  Google Scholar 

  11. Zedler B, Xie L, Wang L, Joyce A, Vick C, Brigham Rands J, Kariburyo F, Baser O, Murrelle L. Risk factors for serious prescription opioid-related toxicity or overdose among veterans health administration patients. Pain Med. 2014.

    Google Scholar 

  12. Ruan X, et al. Respiratory failure following delayed intrathecal morphine pump refill: a valuable, but costly lesson. Pain Physician. 2010;13(4):337–41.

    Google Scholar 

  13. Coffey RJ, et al. Mortality associated with implantation and management of intrathecal opioid drug infusion systems to treat noncancer pain. Anesthesiology. 2009;111(4).

    Google Scholar 

  14. Jumbelic M. Deaths with transdermal fentanyl patches. Am J Forensic Med Pathol. 2010;31:18–21.

    Article  PubMed  Google Scholar 

  15. Zedler B, Xie L, Wang L, Joyce A, Vick C, Brigham Rands J, Kariburyo F, Baser O, Murrelle L. Risk factors for serious prescription opioid-related toxicity or overdose among veterans health administration patients. Pain Med. 2014.

    Google Scholar 

  16. Substance Abuse and Mental Health Services Administration. SAMHSA opioid overdose prevention toolkit. HHS Publication No. (SMA) 14–4742. Rockville MD: Substance Abuse and Mental Health Services Administration. 2014.

    Google Scholar 

  17. Wolfe TR. Bernstone T intranasal drug delivery: An alternative to intravenous administration in selected emergency cases. J Emerg Nurs. 2004;30(2):141–7.

    Article  PubMed  Google Scholar 

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Correspondence to Sanford M. Silverman MD .

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© 2016 Springer International Publishing Switzerland

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Silverman, S.M., Staats, P.S. (2016). Naloxone Treatment of Opioid Overdose. In: Staats, P., Silverman, S. (eds) Controlled Substance Management in Chronic Pain. Springer, Cham. https://doi.org/10.1007/978-3-319-30964-4_11

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  • DOI: https://doi.org/10.1007/978-3-319-30964-4_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-30962-0

  • Online ISBN: 978-3-319-30964-4

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