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In Vivo Agents and Markers for Endomicroscopy

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Endoscopic Imaging Techniques and Tools

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Abstract

Novel in vivo agents and molecular markers are steadily enhancing the field of endoscopy. By resolving glandular patterns and subcellular features, these targeted agents can provide endoscopists with near histologic-grade images of gastrointestinal disease. This chapter will review the clinical research in vital-dye, contrast, peptide, molecular, and mucolytic agents that have been studied to better target suspicious lesions for biopsy. To start off, the characteristics of each agent will be summarized. Then, the chapter will examine each organ system (esophagus, stomach, and colon) in turn and discuss how agents and their respective imaging systems have performed.

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Abbreviations

2-NBDG:

2-[N-(7-nitrobenz-2-oxa-1,3-diaxol-4-yl) amino]-2-deoxyglucose

CLE:

Confocal laser endomicroscopy

eCLE:

Endoscopic-integrated CLE

ECS:

Endocytoscopy

HRME:

High-resolution microendoscopy

IBD:

Inflammatory bowel disease

MCE:

Magnification chromoendoscopy

MDM:

Multispectral digital microscope

mTNF:

Membrane-bound tumor necrosis factor

NIR:

Near-infrared imaging

pCLE:

Probe-based CLE

WLE:

White-light endoscopy

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Authors and Affiliations

  1. Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA

    Daniel P. Perl M.D.

  2. Medicine and Gastroenterology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA

    Sharmila Anandasabapathy M.D.

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  1. Daniel P. Perl M.D.
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Correspondence to Sharmila Anandasabapathy M.D. .

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Editors and Affiliations

  1. Department of Medicine, University of Chicago Medicine, Chicago, Illinois, USA

    Vani J.A. Konda

  2. Biological Sciences, University of Chicago Medicine, Chicago, Illinois, USA

    Irving Waxman

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Perl, D.P., Anandasabapathy, S. (2016). In Vivo Agents and Markers for Endomicroscopy. In: Konda, V., Waxman, I. (eds) Endoscopic Imaging Techniques and Tools. Springer, Cham. https://doi.org/10.1007/978-3-319-30053-5_9

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  • DOI: https://doi.org/10.1007/978-3-319-30053-5_9

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