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Autofluorescence Imaging

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Endoscopic Imaging Techniques and Tools

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Abstract

With the aim to reduce cancer mortality, early detection of neoplasia is one of the most challenging tasks in upper and lower of gastrointestinal endoscopy. Despite microscopic architectural and cellular differences between normal, premalignant and early malignant epithelia, standard endoscopy often fails to be sufficiently informative for the human eye, due to the lack of colour contrast in white-light mode. Autofluorescence imaging (AFI) is based on the property of short wavelengths to excite endogenous molecules in the gastrointestinal mucosa to emit fluorescence and exploits different fluorescent properties of neoplastic compared to normal tissue. Hence, AFI stands as a red-flag wide-field endoscopic technique for early cancer detection.

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Author information

Authors and Affiliations

  1. MRC Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK

    Massimiliano di Pietro M.D.

  2. NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the University of Nottingham, Queens Medical Centre Campus, Nottingham, NG7 2UH, UK

    Krish Ragunath M.D., F.R.C.P., F.A.S.G.E.

Authors
  1. Massimiliano di Pietro M.D.
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  2. Krish Ragunath M.D., F.R.C.P., F.A.S.G.E.
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Corresponding author

Correspondence to Krish Ragunath M.D., F.R.C.P., F.A.S.G.E. .

Editor information

Editors and Affiliations

  1. Department of Medicine, University of Chicago Medicine, Chicago, Illinois, USA

    Vani J.A. Konda

  2. Biological Sciences, University of Chicago Medicine, Chicago, Illinois, USA

    Irving Waxman

Electronic Supplementary Material

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Trimodal imaging demonstrating an early cancer in a short tongue of Barrett’s oesophagus (MP4 3309 kb)

Trimodal imaging demonstrating a flat adenoma in the sigmoid colon (MP4 6093 kb)

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di Pietro, M., Ragunath, K. (2016). Autofluorescence Imaging. In: Konda, V., Waxman, I. (eds) Endoscopic Imaging Techniques and Tools. Springer, Cham. https://doi.org/10.1007/978-3-319-30053-5_5

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  • DOI: https://doi.org/10.1007/978-3-319-30053-5_5

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  • Online ISBN: 978-3-319-30053-5

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