Skip to main content
SpringerLink
Log in

Spectroscopy

  • Chapter
  • First Online:
Endoscopic Imaging Techniques and Tools

  • 740 Accesses

Abstract

One of the major and exciting advances in biomedical optics is the application of spectroscopy to conventional white light endoscopy. Both elastic and inelastic spectroscopic methods may provide information about tissue microstructure and histology, hemoglobin content, and other molecular characteristics. Applications of spectroscopy include optical biopsy for in situ histological determination, flat dysplasia detection, and field carcinogenesis for risk stratification. Incorporation of these advances still requires pragmatic future development including larger trials to validate the technology, standardization of equipment, and investigation into cost, efficacy, and practicality.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Radosevich AJ, Turzhitsky VM, Mutyal NN, Rogers JD, Stoyneva V, Tiwari AK, et al. Depth-resolved measurement of mucosal microvascular blood content using low-coherence enhanced backscattering spectroscopy. Biomed Opt Express. 2010;1(4):1196–208.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Radosevich AJ, Mutyal NN, Eshein A, Nguyen TQ, Gould B, Rogers JD, et al. Rectal optical markers for in-vivo risk stratification of premalignant colorectal lesions. Clin Cancer Res. 2015;21(19):4347–55.

    Article  CAS  PubMed  Google Scholar 

  3. Mutyal NN, Radosevich AJ, Bajaj S, Konda V, Siddiqui UD, Waxman I, et al. In vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa. Pancreas. 2015;44(5):735–41.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Radosevich AJ, Mutyal NN, Rogers JD, Gould B, Hensing TA, Ray D, et al. Buccal spectral markers for lung cancer risk stratification. PLoS One. 2014;9(10):e110157.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Committee AT. Enhanced imaging in the GI tract: spectroscopy and optical coherence tomography. Gastrointest Endosc. 2013;78(4):568–73.

    Article  Google Scholar 

  6. Nima ZA, Biswas A, Bayer IS, Hardcastle FD, Perry D, Ghosh A, et al. Applications of surface-enhanced Raman scattering in advanced bio-medical technologies and diagnostics. Drug Metab Rev. 2014;46(2):155–75.

    Article  PubMed  Google Scholar 

  7. Almond LM, Hutchings J, Lloyd G, Barr H, Shepherd N, Day J, et al. Endoscopic Raman spectroscopy enables objective diagnosis of dysplasia in Barrett’s esophagus. Gastrointest Endosc. 2014;79(1):37–45.

    Article  PubMed  Google Scholar 

  8. Kara MA, DaCosta RS, Streutker CJ, Marcon NE, Bergman JJ, Wilson BC. Characterization of tissue autofluorescence in Barrett’s esophagus by confocal fluorescence microscopy. Dis Esophagus. 2007;20(2):141–50.

    Article  CAS  PubMed  Google Scholar 

  9. Bourg-Heckly G, Blais J, Padilla JJ, Bourdon O, Etienne J, Guillemin F, et al. Endoscopic ultraviolet-induced autofluorescence spectroscopy of the esophagus: tissue characterization and potential for early cancer diagnosis. Endoscopy. 2000;32(10):756–65.

    Article  CAS  PubMed  Google Scholar 

  10. Winawer SJ, Fletcher RH, Miller L, Godlee F, Stolar MH, Mulrow CD, et al. Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology. 1997;112(2):594–642.

    Article  CAS  PubMed  Google Scholar 

  11. Zauber AG, Winawer SJ, O’Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med. 2012;366(8):687–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Baxter NN, Warren JL, Barrett MJ, Stukel TA, Doria-Rose VP. Association between colonoscopy and colorectal cancer mortality in a US cohort according to site of cancer and colonoscopist specialty. J Clin Oncol. 2012;30(21):2664–9.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Singh H, Nugent Z, Demers AA, Kliewer EV, Mahmud SM, Bernstein CN. The reduction in colorectal cancer mortality after colonoscopy varies by site of the cancer. Gastroenterology. 2010;139(4):1128–37.

    Article  PubMed  Google Scholar 

  14. Brenner H, Chang-Claude J, Jansen L, Knebel P, Stock C, Hoffmeister M. Reduced risk of colorectal cancer up to 10 years after screening, surveillance, or diagnostic colonoscopy. Gastroenterology. 2014;146(3):709–17.

    Article  PubMed  Google Scholar 

  15. Imperiale TF, Glowinski EA, Juliar BE, Azzouz F, Ransohoff DF. Variation in polyp detection rates at screening colonoscopy. Gastrointest Endosc. 2009;69(7):1288–95.

    Article  PubMed  Google Scholar 

  16. Shaukat A, Oancea C, Bond JH, Church TR, Allen JI. Variation in detection of adenomas and polyps by colonoscopy and change over time with a performance improvement program. Clin Gastroenterol Hepatol. 2009;7(12):1335–40.

    Article  PubMed  Google Scholar 

  17. Imperiale TF, Ransohoff DF, Itzkowitz SH, Turnbull BA, Ross ME. Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N Engl J Med. 2004;351(26):2704–14.

    Article  CAS  PubMed  Google Scholar 

  18. Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, et al. Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med. 2014;370(14):1287–97.

    Article  CAS  PubMed  Google Scholar 

  19. Johnson CD, Chen MH, Toledano AY, Heiken JP, Dachman A, Kuo MD, et al. Accuracy of CT colonography for detection of large adenomas and cancers. N Engl J Med. 2008;359(12):1207–17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Roy HK, Turzhitsky V, Kim Y, Goldberg MJ, Watson P, Rogers JD, et al. Association between rectal optical signatures and colonic neoplasia: potential applications for screening. Cancer Res. 2009;69(10):4476–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Roy HK, Mutyal NN, Goldberg MJ, Du H, Radosevich A, Bianchi LK, et al. 545 In situ rectal spectral markers for colonic neoplasia risk stratification—a blinded validation study. Gastroenterology. 2012;142(5):S-109.

    Google Scholar 

  22. Gomes AJ, Roy HK, Turzhitsky V, Kim Y, Rogers JD, Ruderman S, et al. Rectal mucosal microvascular blood supply increase is associated with colonic neoplasia. Clin Cancer Res. 2009;15(9):3110–7.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Damania D, Roy HK, Subramanian H, Weinberg DS, Rex DK, Goldberg MJ, et al. Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization. Cancer Res. 2012;72(11):2720–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Isenberg G, Chak A. Should there be light in the esophageal tunnel? An appraisal of optical coherence tomography in Barrett’s esophagus. Gastrointest Endosc. 2007;65(1):57–9.

    Article  PubMed  Google Scholar 

  25. Singh M, Gupta N, Gaddam S, Balasubramanian G, Wani S, Sinh P, et al. Practice patterns among U.S. gastroenterologists regarding endoscopic management of Barrett’s esophagus. Gastrointest Endosc. 2013;78(5):689–95.

    Article  PubMed  Google Scholar 

  26. Kerkhof M, van Dekken H, Steyerberg EW, Meijer GA, Mulder AH, de Bruine A, et al. Grading of dysplasia in Barrett’s oesophagus: substantial interobserver variation between general and gastrointestinal pathologists. Histopathology. 2007;50(7):920–7.

    Article  CAS  PubMed  Google Scholar 

  27. Falk GW, Rice TW, Goldblum JR, Richter JE. Jumbo biopsy forceps protocol still misses unsuspected cancer in Barrett’s esophagus with high-grade dysplasia. Gastrointest Endosc. 1999;49(2):170–6.

    Article  CAS  PubMed  Google Scholar 

  28. Cameron AJ, Carpenter HA. Barrett’s esophagus, high-grade dysplasia, and early adenocarcinoma: a pathological study. Am J Gastroenterol. 1997;92(4):586–91.

    CAS  PubMed  Google Scholar 

  29. Reid BJ, Blount PL, Feng Z, Levine DS. Optimizing endoscopic biopsy detection of early cancers in Barrett’s high-grade dysplasia. Am J Gastroenterol. 2000;95(11):3089–96.

    Article  CAS  PubMed  Google Scholar 

  30. Lovat LB, Johnson K, Mackenzie GD, Clark BR, Novelli MR, Davies S, et al. Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett’s oesophagus. Gut. 2006;55(8):1078–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29.

    Article  PubMed  Google Scholar 

  32. Turzhitsky V, Liu Y, Hasabou N, Goldberg M, Roy HK, Backman V, et al. Investigating population risk factors of pancreatic cancer by evaluation of optical markers in the duodenal mucosa. Dis Markers. 2008;25(6):313–21.

    Article  PubMed  Google Scholar 

  33. Gupta N, Bansal A, Rao D, Early DS, Jonnalagadda S, Wani SB, et al. Prevalence of advanced histological features in diminutive and small colon polyps. Gastrointest Endosc. 2012;75(5):1022–30.

    Article  PubMed  Google Scholar 

  34. Hassan C, Pickhardt PJ, Kim DH, Di Giulio E, Zullo A, Laghi A, et al. Systematic review: distribution of advanced neoplasia according to polyp size at screening colonoscopy. Aliment Pharmacol Ther. 2010;31(2):210–7.

    CAS  PubMed  Google Scholar 

  35. Longcroft-Wheaton G, Brown J, Cowlishaw D, Higgins B, Bhandari P. High-definition vs. standard-definition colonoscopy in the characterization of small colonic polyps: results from a randomized trial. Endoscopy. 2012;44(10):905–10.

    Article  CAS  PubMed  Google Scholar 

  36. Chiu HM, Chang CY, Chen CC, Lee YC, Wu MS, Lin JT, et al. A prospective comparative study of narrow-band imaging, chromoendoscopy, and conventional colonoscopy in the diagnosis of colorectal neoplasia. Gut. 2007;56(3):373–9.

    Article  PubMed  Google Scholar 

  37. Su MY, Hsu CM, Ho YP, Chen PC, Lin CJ, Chiu CT. Comparative study of conventional colonoscopy, chromoendoscopy, and narrow-band imaging systems in differential diagnosis of neoplastic and nonneoplastic colonic polyps. Am J Gastroenterol. 2006;101(12):2711–6.

    Article  PubMed  Google Scholar 

  38. Gupta N, Bansal A, Rao D, Early DS, Jonnalagadda S, Edmundowicz SA, et al. Accuracy of in vivo optical diagnosis of colon polyp histology by narrow-band imaging in predicting colonoscopy surveillance intervals. Gastrointest Endosc. 2012;75(3):494–502.

    Article  PubMed  Google Scholar 

  39. Ladabaum U, Fioritto A, Mitani A, Desai M, Kim JP, Rex DK, et al. Real-time optical biopsy of colon polyps with narrow band imaging in community practice does not yet meet key thresholds for clinical decisions. Gastroenterology. 2013;144(1):81–91.

    Article  PubMed  Google Scholar 

  40. Rodriguez-Diaz E, Huang Q, Cerda SR, O'Brien MJ, Bigio IJ, Singh SK. Endoscopic histological assessment of colonic polyps by using elastic scattering spectroscopy. Gastrointest Endosc. 2015;81(3):539–47.

    Article  PubMed  Google Scholar 

Download references

Disclosure

Dr. Roy is a co-founder of Nanocytomics LLC and American BioOptics LLC.

Author information

Authors and Affiliations

  1. Boston University Medical Center, 85 E Concord Avenue, Boston, MA, 02118, USA

    Tian Gao M.D. & Hemant K. Roy M.D.

Authors
  1. Tian Gao M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hemant K. Roy M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tian Gao M.D. .

Editor information

Editors and Affiliations

  1. Department of Medicine, University of Chicago Medicine, Chicago, Illinois, USA

    Vani J.A. Konda

  2. Biological Sciences, University of Chicago Medicine, Chicago, Illinois, USA

    Irving Waxman

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Gao, T., Roy, H.K. (2016). Spectroscopy. In: Konda, V., Waxman, I. (eds) Endoscopic Imaging Techniques and Tools. Springer, Cham. https://doi.org/10.1007/978-3-319-30053-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-30053-5_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-30051-1

  • Online ISBN: 978-3-319-30053-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation