Abstract
The aim of the paper is to study medical image retrieval for Alzheimer’s Disease (AD) on the bases of structural MRI measures. The main goal of the strategy used in this paper is to improve the retrieval performance while using smaller number of features. The feature vector consists of the measurements of cortical and subcortical brain structures, including volumes of the brain structures and cortical thickness. The feature subset selection is additionally applied using the Correlation-based Feature Selection method to exclude irrelevant, redundant or possibly noisy data and to consider the most relevant and discriminative features. Six different scenarios for the image representation are studied: volumetric features, cortical thickness features, all imaging features, selected volumetric features, selected cortical thickness feature and selected imaging features. Euclidean distance is used as a similarity measurement. The dataset used for evaluation of the retrieval performance is provided by the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Experimental results show that the strategy used in this research outperforms the traditional one despite its simplicity and small number of features used for representation. Additionally, the performed analysis demonstrated that the selected features are highly stable through the leave-one-out strategy. Moreover, they are stressed in the literature as significant biomarkers for Alzheimer’s Disease, which makes the strategy used in this research even more reasonable.
*Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf
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Trojacanec, K., Kitanovski, I., Dimitrovski, I., Loshkovska, S.: Content based retrieval of MRI based on brain structure changes in Alzheimer’s disease. In: Proceedings of the International Conference on Bioimaging, pp. 13–22. doi:10.5220/0005182200130022 (2015)
Acknowledgements
Data collection and sharing for this project was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). The National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Alzheimer’s Association; Alzheimer’s Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Synarc Inc.; and Takeda Pharmaceutical Company are all funders of ADNI. ADNI clinical sites in Canada are supported and funded by the Canadian Institutes of Health Research. Private sector contributions are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The study is coordinated by the Alzheimer’s Disease Cooperative Study at the University of California, San Diego, whereas the grantee organization for it, is the Northern California Institute for Research and Education. The Laboratory for Nero Imaging at the University of Southern California is dissemination the ADNI data.
Authors also acknowledge the support of the European Commission through the project MAESTRA - Learning from Massive, Incompletely annotated, and Structured Data (Grant number ICT-2013-612944).
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Trojacanec, K., Kitanovski, I., Dimitrovski, I., Loshkovska, S., for the Alzheimer’s Disease Neuroimaging Initiative*. (2015). Medical Image Retrieval for Alzheimer’s Disease Using Structural MRI Measures. In: Fred, A., Gamboa, H., Elias, D. (eds) Biomedical Engineering Systems and Technologies. BIOSTEC 2015. Communications in Computer and Information Science, vol 574. Springer, Cham. https://doi.org/10.1007/978-3-319-27707-3_9
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