Skip to main content
SpringerLink
Log in

Overview of rheumatoid arthritis and mortality in relation to cardiovascular disease

  • Chapter
  • First Online:
Handbook of Cardiovascular Disease Management in Rheumatoid Arthritis

  • 914 Accesses

Abstract

Rheumatoid arthritis (RA) is a chronic destructive autoimmune disease with significant, often debilitating joint involvement, associated extraarticular manifestations, excess comorbidity and increased mortality.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alamanos Y, Voulgari PV, Drosos AA. Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: a systematic review. Semin Arthritis Rheum. 2006;36:182-188.

    Google Scholar 

  2. Hochberg MC. Changes in the incidence and prevalence of rheumatoid arthritis in England and Wales, 1970-1982. Semin Arthritis Rheum. 1990;19:294-302.

    Google Scholar 

  3. Kaipiainen-Seppanen O, Aho K, Isomaki H, Laakso M. Incidence of rheumatoid arthritis in Finland during 1980-1990. Ann Rheum Dis. 1996;55:608-611.

    Google Scholar 

  4. Gabriel SE, Crowson CS, O’Fallon WM. The epidemiology of rheumatoid arthritis in Rochester, Minnesota, 1955-1985. Arthritis Rheum. 1999;42:415-420.

    Google Scholar 

  5. Shichikawa K, Inoue K, Hirota S, et al. Changes in the incidence and prevalence of rheumatoid arthritis in Kamitonda, Wakayama, Japan, 1965-1996. Ann Rheum Dis. 1999;58:751-756.

    Google Scholar 

  6. Doran MF, Pond GR, Crowson CS, O’Fallon WM, Gabriel SE. Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis Rheum. 2002;46:625-631.

    Google Scholar 

  7. Kaipiainen-Seppanen O, Kautiainen H. Declining trend in the incidence of rheumatoid factorpositive rheumatoid arthritis in Finland 1980-2000. J Rheumatol. 2006;33:2132-2138.

    Google Scholar 

  8. Jacobsson LT, Hanson RL, Knowler WC, et al. Decreasing incidence and prevalence of rheumatoid arthritis in Pima Indians over a twenty-five-year period. Arthritis Rheum. 1994;37:1158-1165.

    Google Scholar 

  9. Akushevich I, Kravchenko J, Ukraintseva S, Arbeev K, Yashin AI. Time trends of incidence of age-associated diseases in the US elderly population: Medicare-based analysis. Age Ageing. 2013;42:494-500.

    Google Scholar 

  10. Myasoedova E, Crowson CS, Kremers HM, Therneau TM, Gabriel SE. Is the incidence of rheumatoid arthritis rising?: results from Olmsted County, Minnesota, 1955-2007. Arthritis Rheum. 2010;62:1576-1582.

    Google Scholar 

  11. Cross M, Smith E, Hoy D, et al. The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73:1316-1322.

    Google Scholar 

  12. Gonzalez A, Maradit Kremers H, Crowson CS, et al. The widening mortality gap between rheumatoid arthritis patients and the general population. Arthritis Rheum. 2007;56:3583-3587.

    Google Scholar 

  13. Gonzalez A, Icen M, Kremers HM, et al. Mortality trends in rheumatoid arthritis: the role of rheumatoid factor. J Rheumatol. 2008;35:1009-1014.

    Google Scholar 

  14. Radovits BJ, Fransen J, Al Shamma S, Eijsbouts AM, van Riel PL, Laan RF. Excess mortality emerges after 10 years in an inception cohort of early rheumatoid arthritis. Arthritis Care Res (Hoboken). 2010;62:362-370.

    Google Scholar 

  15. Ziade N, Jougla E, Coste J. Population-level influence of rheumatoid arthritis on mortality and recent trends: a multiple cause-of-death analysis in France, 1970-2002. J Rheumatol. 2008;35:1950-1957.

    Google Scholar 

  16. Bergstrom U, Jacobsson LT, Turesson C. Cardiovascular morbidity and mortality remain similar in two cohorts of patients with long-standing rheumatoid arthritis seen in 1978 and 1995 in Malmo, Sweden. Rheumatology (Oxford). 2009;48:1600-1605.

    Google Scholar 

  17. Dadoun S, Zeboulon-Ktorza N, Combescure C, et al. Mortality in rheumatoid arthritis over the last fifty years: systematic review and meta-analysis. Joint Bone Spine. 2013;80:29-33.

    Google Scholar 

  18. Crowson CS, Myasoedova E, Matteson EL, Kremers HM, Therneau TM, Gabriel SE. Has survival improved in patients recently diagnosed with rheumatoid arthritis? Arthritis Rheum. 2009;60:1172.

    Google Scholar 

  19. Widdifield J, Bernatsky S, Paterson JM, et al. Trends in excess mortality among patients with rheumatoid arthritis in Ontario, Canada. Arthritis Care Res (Hoboken). 2015;67:1047-1053.

    Google Scholar 

  20. Humphreys JH, Warner A, Chipping J, et al. Mortality trends in patients with early rheumatoid arthritis over 20 years: results from the Norfolk Arthritis Register. Arthritis Care Res (Hoboken). 2014;66:1296-1301.

    Google Scholar 

  21. Sokka T, Abelson B, Pincus T. Mortality in rheumatoid arthritis: 2008 update. Clin Exp Rheumatol. 2008;26:S35-S61.

    Google Scholar 

  22. England BR, Sayles H, Michaud K, et al. Cause-specific mortality in US veteran men with rheumatoid arthritis. Arthritis Care Res (Hoboken). 20156;68:35-45.

    Google Scholar 

  23. Avina-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D. Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis Rheum. 2008;59:1690-1697.

    Google Scholar 

  24. Meune C, Touze E, Trinquart L, Allanore Y. Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analysis of cohort studies. Rheumatology (Oxford). 2009;48:1309-1313.

    Google Scholar 

  25. Meek IL, Vonkeman HE, van de Laar MA. Cardiovascular case fatality in rheumatoid arthritis is decreasing; first prospective analysis of a current low disease activity rheumatoid arthritis cohort and review of the literature. BMC Musculoskelet Disord. 2014;15:142.

    Google Scholar 

  26. Myasoedova E CC, Matteson EL, Davis JM III, Therneau TM, Gabriel SE. Decreased cardiovascular mortality in patients with incident rheumatoid arthritis (RA) in recent years: dawn of a new era in cardiovascualar disease in RA? Arthritis Rheumatol. 2015;67.

    Google Scholar 

  27. Wolfe F, Michaud K. The risk of myocardial infarction and pharmacologic and nonpharmacologic myocardial infarction predictors in rheumatoid arthritis: a cohort and nested case-control analysis. Arthritis Rheum. 2008;58:2612-2621.

    Google Scholar 

  28. Davis JM, 3rd, Roger VL, Crowson CS, Kremers HM, Therneau TM, Gabriel SE. The presentation and outcome of heart failure in patients with rheumatoid arthritis differs from that in the general population. Arthritis Rheum. 2008;58:2603-2611.

    Google Scholar 

  29. Masuda H, Miyazaki T, Shimada K, et al. Disease duration and severity impacts on long-term cardiovascular events in Japanese patients with rheumatoid arthritis. J Cardiol. 2014;64: 366-370.

    Google Scholar 

  30. Peters MJ, van Halm VP, Voskuyl AE, et al. Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study. Arthritis Rheum. 2009;61:1571-1579.

    Google Scholar 

  31. van Halm VP, Peters MJ, Voskuyl AE, et al. Rheumatoid arthritis versus diabetes as a risk factor for cardiovascular disease: a cross-sectional study, the CARRE Investigation. Ann Rheum Dis. 2009;68:1395-1400.

    Google Scholar 

  32. Lindhardsen J, Ahlehoff O, Gislason GH, et al. The risk of myocardial infarction in rheumatoid arthritis and diabetes mellitus: a Danish nationwide cohort study. Ann Rheum Dis. 2011;70:929-934.

    Google Scholar 

  33. Solomon DH, Goodson NJ, Katz JN, et al. Patterns of cardiovascular risk in rheumatoid arthritis. Ann Rheum Dis. 2006;65:1608-1612.

    Google Scholar 

  34. Kremers HM, Crowson CS, Therneau TM, Roger VL, Gabriel SE. High ten-year risk of cardiovascular disease in newly diagnosed rheumatoid arthritis patients: a population-based cohort study. Arthritis Rheum. 2008;58:2268-2274.

    Google Scholar 

  35. Wallberg-Jonsson S, Ohman ML, Dahlqvist SR. Cardiovascular morbidity and mortality in patients with seropositive rheumatoid arthritis in Northern Sweden. J Rheumatol. 1997;24:445-451.

    Google Scholar 

  36. Naz SM, Farragher TM, Bunn DK, Symmons DP, Bruce IN. The influence of age at symptom onset and length of followup on mortality in patients with recent-onset inflammatory polyarthritis. Arthritis Rheum. 2008;58:985-989.

    Google Scholar 

  37. Goodson NJ, Wiles NJ, Lunt M, Barrett EM, Silman AJ, Symmons DP. Mortality in early inflammatory polyarthritis: cardiovascular mortality is increased in seropositive patients. Arthritis Rheum. 2002;46:2010-2019.

    Google Scholar 

  38. Goodson NJ, Symmons DP, Scott DG, Bunn D, Lunt M, Silman AJ. Baseline levels of C-reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis: a ten-year followup study of a primary care-based inception cohort. Arthritis Rheum. 2005;52:2293-2299.

    Google Scholar 

  39. Farragher TM, Goodson NJ, Naseem H, et al. Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis. Arthritis Rheum. 2008;58:359-369.

    Google Scholar 

  40. Ajeganova S, Andersson ML, Frostegard J, Hafstrom I. Disease factors in early rheumatoid arthritis are associated with differential risks for cardiovascular events and mortality depending on age at onset: a 10-year observational cohort study. J Rheumatol. 2013;40: 1958-1966.

    Google Scholar 

  41. Maradit-Kremers H, Crowson CS, Nicola PJ, et al. Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study. Arthritis Rheum. 2005;52:402-411.

    Google Scholar 

  42. Avina-Zubieta JA, Thomas J, Sadatsafavi M, Lehman AJ, Lacaille D. Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies. Ann Rheum Dis. 2012;71:1524-1529.

    Google Scholar 

  43. Karpouzas GA, Malpeso J, Choi TY, Li D, Munoz S, Budoff MJ. Prevalence, extent and composition of coronary plaque in patients with rheumatoid arthritis without symptoms or prior diagnosis of coronary artery disease. Ann Rheum Dis. 2014;73:1797-1804.

    Google Scholar 

  44. Holmqvist ME, Wedren S, Jacobsson LT, et al. No increased occurrence of ischemic heart disease prior to the onset of rheumatoid arthritis: results from two Swedish population-based rheumatoid arthritis cohorts. Arthritis Rheum. 2009;60:2861-2869.

    Google Scholar 

  45. Holmqvist ME, Wedren S, Jacobsson LT, et al. Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006. J Intern Med. 2010;268:578-585.

    Google Scholar 

  46. Dougados M, Soubrier M, Antunez A, et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis. 2014;73:62-68.

    Google Scholar 

  47. Van Doornum S, Brand C, Sundararajan V, Ajani AE, Wicks IP. Rheumatoid arthritis patients receive less frequent acute reperfusion and secondary prevention therapy after myocardial infarction compared with the general population. Arthritis Res Ther. 2010;12:R183.

    Google Scholar 

  48. Van Doornum S, Bohensky M, Tacey MA, Brand CA, Sundararajan V, Wicks IP. Increased 30-day and 1-year mortality rates and lower coronary revascularisation rates following acute myocardial infarction in patients with autoimmune rheumatic disease. Arthritis Res Ther. 2015;17:38.

    Google Scholar 

  49. Francis ML, Varghese JJ, Mathew JM, Koneru S, Scaife SL, Zahnd WE. Outcomes in patients with rheumatoid arthritis and myocardial infarction. Am J Med. 2010;123:922-928.

    Google Scholar 

  50. Varghese JJ, Koneru S, Scaife SL, Zahnd WE, Francis ML. Mortality after coronary artery revascularization of patients with rheumatoid arthritis. J Thorac Cardiovasc Surg. 2010;140:91-96.

    Google Scholar 

  51. Lai CH, Lai WW, Chiou MJ, Tsai LM, Wen JS, Li CY. Outcomes of coronary artery bypass grafting in patients with inflammatory rheumatic diseases: an 11-year nationwide cohort study. J Thorac Cardiovasc Surg. 2015;149:859-866.

    Google Scholar 

  52. McCoy SS, Crowson CS, Maradit-Kremers H, et al. Longterm outcomes and treatment after myocardial infarction in patients with rheumatoid arthritis. J Rheumatol. 2013;40:605-610.

    Google Scholar 

  53. Nicola PJ, Maradit-Kremers H, Roger VL, et al. The risk of congestive heart failure in rheumatoid arthritis: a population-based study over 46 years. Arthritis Rheum. 2005;52:412-420.

    Google Scholar 

  54. Wolfe F, Michaud K. Heart failure in rheumatoid arthritis: rates, predictors, and the effect of anti-tumor necrosis factor therapy. Am J Med. 2004;116:305-311.

    Google Scholar 

  55. Midtbo H, Gerdts E, Kvien TK, et al. Disease activity and left ventricular structure in patients with rheumatoid arthritis. Rheumatology (Oxford). 2015;54:511-519.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mayo Clinic College of Medicine, Rochester, USA

    Elena Myasoedova

  2. Robert Wood Johnson Medical Group, New Brunswick, USA

    Sherine E. Gabriel

Authors
  1. Elena Myasoedova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sherine E. Gabriel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Preventive Cardio-Rheuma Clinic, Diakonhjemmet Hospital, Oslo, Oslo, Norway

    Anne Grete Semb

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Myasoedova, E., Gabriel, S.E. (2017). Overview of rheumatoid arthritis and mortality in relation to cardiovascular disease. In: Semb, A. (eds) Handbook of Cardiovascular Disease Management in Rheumatoid Arthritis. Adis, Cham. https://doi.org/10.1007/978-3-319-26782-1_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-26782-1_1

  • Published:

  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-26780-7

  • Online ISBN: 978-3-319-26782-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation