Skip to main content

Process Intensification in Organic Synthesis

  • Chapter
  • First Online:
Paradigms in Green Chemistry and Technology

Part of the book series: SpringerBriefs in Molecular Science ((GREENCHEMIST))

Abstract

Optimization at the scaling up stage and the engineering of the final process at the stage of commercial process contribute to the environmental role of the process as least as much as the merely chemical issues. 12 Principles of green chemical engineering have been formulated, in part parallel to green chemistry. Process intensification involves not only the better use of the space available in the plant, but also revising previous chemistry to introduce novel reactions simultaneously with the development of new (most often multifunctional) apparatuses, with the only predetermined parameter of the better yield. Intrinsically safer procedures are found that are also economically profitable.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    A shorter list has been also proposed, see Abraham M, Nguyen N (2004) Green engineering: defining principles-results from the Sandestin conference. Environmental Progress 22:233–236.

    1. 1.

      Engineer processes and products holistically, use systems analysis, and integrate environmental impact assessment tools.

    2. 2.

      Conserve and improve natural ecosystems while protecting human health and wellbeing.

    3. 3.

      Use life-cycle thinking in all engineering activities.

    4. 4.

      Ensure that all material and energy inputs and outputs are as inherently safe and benign as possible.

    5. 5.

      Minimize depletion of natural resources.

    6. 6.

      Strive to prevent waste.

    7. 7.

      Develop and apply engineering solutions, while being cognizant of local geography, aspirations, and cultures.

    8. 8.

      Create engineering solutions beyond current or dominant technologies; improve, innovate, and invent (technologies) to achieve sustainability.

    9. 9.

      Actively engage communities and stakeholders in development of engineering solutions.

References

  1. Adriano DC (2001) Trace elements in terrestrial environments. Biogeochemistry, bioavailability, and risks of metals. In: Daughton CG, Jones-Lepp TL (eds) Pharmaceuticals and personal care products in the environment: scientific and regulatory issues, ACS symposium series 791, American Chemical Society, Washington. Springer, New York

    Google Scholar 

  2. Anastas, PT, Zimmerman JB (2003) Design through the twelve principles of green engineering. Env Sci Tech 37:94A–101A. See also Garcìa-Serna J, Pérez-Barrigòn L, Cocero MJ (2003) New trends for design towards sustainability in chemical engineering: green engineering. Chem Eng J 133:7–30

    Google Scholar 

  3. Constable DC. In http://www.acs.org/content/acs/en/greenchemistry/what-is-green-chemistry/principles.html

  4. Abraham M in Ref. [3]

    Google Scholar 

  5. Reallf MJ, Wang D in Ref. [3]

    Google Scholar 

  6. Gonzalez MA in Ref. [3]

    Google Scholar 

  7. Mattews MA in Ref. [3]

    Google Scholar 

  8. Jiménez Gonzàlez C in Ref. [3]

    Google Scholar 

  9. Anastas PT, Zimmerman JB (2003) Design through the twelve principles of green engineering. Env Sci Tech 37:94A–101A

    Article  Google Scholar 

  10. (a) Stankiewicz AI, Moulijn JA (eds) (2004) Reengineering the chemical processing plant. Process intensification. Marcel Dekker, New York. (b) Ramshaw C (1985) Process intensification: heat and mass transfer. Chem Eng 415:30–33

    Google Scholar 

  11. Denčić I, Ott D, Kralisch D, Noël T, Meuldijk J, de Croon M, Hessel V, Laribi Y, Perrichon P (2014) Eco-efficiency analysis for intensified production of an active pharmaceutical ingredient: a case study. Org Proc Res Dev 18:1326–1338

    Article  Google Scholar 

  12. (a) Kumar V, Nigam KDP (2012) Process intensification in green synthesis. Green Process Synth 1:79–107. (b) For different process intensification techniques, see for reviews: Stankiewicz A (2003) Reactive separations for process intensification: an industrial perspective. Chem Eng Process 42:137–144. (c) Malone MF, Huss RS, Doherty MF (2003) Green chemical engineering aspects of reactive distillation. Environ Sci Technol 37:5325–5329

    Google Scholar 

  13. See for instance Antes J, Boskovic D, Krause H, Loebbecke S, Lutz N, Tuercke T, Schweikert W (2003) Analysis and improvement of strong exothermic nitrations in microreactors. Chem Eng Res Des 81:760–765

    Google Scholar 

  14. BHR Group. www.bhrgroup.com/pi/aboutpi.htm. Keil FJ (ed) (2007) Modeling of process intensification. Wiley, Weinheim

  15. Hessel V (2009) Novel process windows—gate to maximizing process intensification via flow chemistry. Chem Eng Technol 32:1655–1681

    Article  CAS  Google Scholar 

  16. Noeres C, Kenig EY, Gòrak A (2003) Modelling of reactive separation processes: reactive absorption and reactive distillation Chem Eng Process 42:157–178

    Google Scholar 

  17. Harvey P, Mackley AP, Selinger MR (2003) Process intensification of biodiesel production using a continuous oscillatory flow reactor. J Chem Technol Biotechnol 78:338–341

    Article  CAS  Google Scholar 

  18. Britton J, Raston CL (2014) Continuous flow vortex fluidic production of biodiesel. RSC Adv 4:49850–49854

    Article  CAS  Google Scholar 

  19. Bertoldi C, da Silva C, Bernardon JP, Corazza ML, Filho LC, Oliveira JV, Corazza FC (2009) Continuous production of biodiesel from soybean oil in supercritical ethanol and carbon dioxide as cosolvent. Energy Fuels 23:5165–5172

    Article  CAS  Google Scholar 

  20. Jähnisch K, Baerns M, Hessel V, Ehrfeld W, Haverkamp V, Löwe H, Wille C, Guber A (2000) Direct fluorination of toluene using elemental fluorine in gas/liquid microreactors. J Fluorine Chem 105:117–128

    Article  Google Scholar 

  21. de Mas N, Günther A, Schmidt MA, Jensen KF (2003) Microfabricated multiphase reactors for the selective direct fluorination of aromatics. Ind Eng Chem Res 42:698–710

    Article  Google Scholar 

  22. Ugi I, Almstetter M, Gruber B, Heilingbrunner M (1997) MCR XII. Efficient development of new drugs by online-optimization of molecular libraries. Springer, Berlin, pp 190–194

    Google Scholar 

  23. Mitchell MC, Spikmans V, Bessot F, Manz A, de Mello A (2000) Towards organic synthesis in microfluidic devices: multicomponent reactions for the construction of compound libraries. Kluwer, Dordrect, pp 463–465

    Google Scholar 

  24. Zhang X, Stefanick S, Villani FJ (2004) Application of microreactor technology in process development. Org Proc Res Dev 8:455–460

    Article  CAS  Google Scholar 

  25. Ratner DM, Murphy ER, Jhunjhunwala MG, Snyder DA, Jensen KF, Seeberger PH (2005) Microreactor-based reaction optimization in organic chemistry-glycosylation as a challenge. Chem Commun 578–580

    Google Scholar 

  26. Odedra A, Geyer K, Gustafsson T, Gilmour T, Seeberger PH (2008) Safe, facile radical-based reduction and hydrosilylation reactions in a microreactor using tris(trimethylsilyl)silane. Chem Commun 3025–3027

    Google Scholar 

  27. Leyva-Pérez A, Garcia PG, Corma A (2014) Multisite organic–inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs. Angew Chem Int Ed 53:8687–8690

    Article  Google Scholar 

  28. Climent MJ, Corma A, Iborra S, Martinez-Silvestre S (2013) Gold catalysis opens up a new route for the synthesis of benzimidazoylquinoxaline derivatives from biomass-derived products (glycerol). ChemCatChem 5:3866–3874

    Article  CAS  Google Scholar 

  29. Krtschil U, Hessel V, Kost HJ, Reinhard D (2013) Kolbe-Schmitt flow synthesis in aqueous solution—from lab capillary reactor to pilot plant. Chem Eng Technol 36:1010–1016

    Article  CAS  Google Scholar 

  30. Ott D, Kralisch D, Dencic I, Hessel V, Laribi Y, Perrichon PD, Berguerand C, Kiwi-Minsker L, Loeb P (2014) Life cycle analysis within pharmaceutical process optimization and intenfication: case study of active pharmaceutical ingredient. ChemSusChem 7:3521–3533

    Article  CAS  Google Scholar 

  31. Kralisch D, Ott D, Gericke D (2015) Rules and benefits of life cycle assessment in green chemical process and synthesis design: a tutorial review. Green Chem 17:123–145

    Article  CAS  Google Scholar 

  32. Boodhoo K, Harvey A (eds) (2013) Process intensification for green chemistry. Engineering solutions for sustainable chemical processing. Wiley, New York. Renken A (2014) Process intensification for clean catalytic technology. In: Wilson K, Lee AF (eds) Heterogeneous catalysts for clean technology, pp 333–364

    Google Scholar 

  33. Van der Vorst G, Aelterman W, De Witte B, Heirman B, Van Langenhove H, Dewulf J (2013) Reduced resource consumption through three generations of Galantamine·HBr synthesis. Green Chem 15:744–748

    Article  Google Scholar 

  34. Long Chen L, Sharifzadeh M, Mac Dowell N, Welton T, Shahc N, Hallett JP (2014) Inexpensive ionic liquids: [HSO4]-based solvent production at bulk scale. Green Chem 16:3098–3106

    Article  Google Scholar 

  35. Chen B, Li F, Huang Z, Lu T, Yuan Y, Yuan G (2014) Integrated catalytic process to directly convert furfural to levulinate ester with high selectivity. ChemSusChem 7:202–209; see also: Sanders JPM, Clark JH, Harmsenc GJ, Heeres HJ, Heijnend JJ, Kerstene SRA, van Swaaije WPM, Moulijn JA (2012) Process intensification in the future production of base chemicals from biomass. Chem Eng Process 51:117–136

    Google Scholar 

  36. Noël T, Kuhn S, Musacchio AJ, Jensen KF, Buchwald SL (2011) Suzuki–Miyaura cross-coupling reactions in flow: multistep synthesis enabled by a microfluidic extraction. Angew Chem 123:6065–6068. For recent reviews on flow synthesis see: Mason BP, Price KE, Steinbacher JL, Bogdan AR, McQuade DT (2007) Greener approaches to organic synthesis using microreactor technology. Chem Rev 107:2300–2318. Vaccaro L, Lanari D, Marrocchi A, Strappaveccia G (2014) Flow approaches towards sustainability. Green Chem 16:3680–3704. Malet-Sanz L, Flavien Susanne L (2012) Continuous flow synthesis. A pharma perspective. J Med Chem 55:4062–4098. Gutmann B, Cantillo D, Kappe CO (2015) Continuous-flow technology—A tool for the safe manufacturing of active pharmaceutical ingredients. Angew Chem Int Ed 54:6688–6728

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Angelo Albini .

Rights and permissions

Reprints and permissions

Copyright information

© 2016 The Author(s)

About this chapter

Cite this chapter

Albini, A., Protti, S. (2016). Process Intensification in Organic Synthesis. In: Paradigms in Green Chemistry and Technology. SpringerBriefs in Molecular Science(). Springer, Cham. https://doi.org/10.1007/978-3-319-25895-9_6

Download citation

Publish with us

Policies and ethics