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The Role of Thyroid Hormones in Neural Development

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Thyroid Disorders

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Abstract

A key aim of this chapter was to review the molecular events associated with the regulation of neural development by thyroid hormones. These molecules are produced in the thyroid gland, and secreted into the bloodstream, where they interact with a number of carrier proteins to facilitate distribution to target tissues. A range of transporter proteins are also present to facilitate uptake in tissues that require TH for their normal development. Research over several decades has shown that TH can regulate neural gene expression both at the transcriptional and post-transcriptional levels. This review focuses partly on the ability of TH to modulate genes encoding cytoskeletal proteins involved in the regulation neural cell proliferation and differentiation, and how dysregulation of TH is associated with cytoskeletal disruption. It also discusses selected non-genomic mechanisms by which TH can influence cytoskeletal involvement in development and other important cell functions.

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  1. Interdisciplinary Biomedical Research Centre, School of Science & Technology, Nottingham Trent University, Nottingham, UK

    Alan J. Hargreaves

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  1. Internal Medicine, Al-Mouwasat Hospital, Jubail, Saudi Arabia

    Syed Khalid Imam

  2. School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom

    Shamim I. Ahmad

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Hargreaves, A.J. (2016). The Role of Thyroid Hormones in Neural Development. In: Imam, S., Ahmad, S. (eds) Thyroid Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-25871-3_4

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