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Iodine and the Thyroid

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Thyroid Disorders

Abstract

Iodine Deficiency Disorders (IDD) are among the most significant public health problems in the world at the present time, especially among children and pregnant women, considered the highest risk population. These disorders hinder socio-economic development in the affected areas. IDD are a permanent natural occurrence that affects the entire planet, which means that the people living in iodine-deficient areas will always be exposed to the consequences of that deficiency, in particular increased perinatal mortality, mental retardation and brain developmental delay. Consequently, it is the major cause of preventable brain damage in childhood, and its elimination is one of the biggest challenges in public health. Iodine is present in small amounts in the body and its main role is to act as the substrate for thyroid hormone synthesis. When dietary requirements are not met, the frequency of IDD increases. In general, these disorders are underdiagnosed and, in many countries, there is no awareness of the associated problems or of the iodine status in the population.

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References

  1. Zimmerman MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015. Published Online 13 Jan 2015. http://dx.doi.org/10.1016/S2213-8587(14)70225-6.

  2. Lazarus JH. The importance of iodine in public health. Environ Geochem Health. 2015;37(4):605–18.

    Google Scholar 

  3. Nyenwe EA, Dagogo-Jack S. Iodine deficiency disorders in the iodine-replete environment. Am J Med Sci. 2009;337(1):37–40.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Zimmermann MB, Andersson M. Assessment of iodine nutrition in populations: past, present, and future. Nutr Rev. 2012;70:553–70.

    Article  PubMed  Google Scholar 

  5. de Benoist B, McLean E, Andersson M. Iodine deficiency in 2007: global progress since 2003. Food Nutr Bull. 2008;29:195–202.

    Article  PubMed  Google Scholar 

  6. Bath SC, Rayman MP. A review of the iodine status of UK pregnant women and its implications for the offspring. Environ Geochem Health. 2015;37(4):619–29.

    Google Scholar 

  7. Masoodi SR, Ali A, Wani AI, Bashir MI, Bhat JA, Mudassar S, Zargar AH. Goitre and urinary iodine excretion survey in schoolchildren of Kashmir Valley. Clin Endocrinol. 2014;80:141–7.

    Article  CAS  Google Scholar 

  8. Ahmed M, Zama SY, Nagarajarao V, Khan MA. Iodine deficiency in children: a comparative study in two districts of south-interior Karnataka. India J Family Community Med. 2014;21(1):48–52.

    Article  PubMed  Google Scholar 

  9. Zou Y, Lou X, Ding G, Mo Z, Zhu W, Mao G, Zhou J. An assessment of iodine nutritional status and thyroid hormone levels in children aged 8–10 years living in Zhejiang Province, China: a cross-sectional study. Eur J Pediatr. 2014;173(7):929–34.

    Article  CAS  PubMed  Google Scholar 

  10. Zimmermann MB. Iodine deficiency and excess in children: worldwide status in 2013. Endocr Pract. 2013;19(5):839–46.

    Article  PubMed  Google Scholar 

  11. Pearce EN, Andersson M, Zimmermann MB. Global iodine nutrition: where do we stand in 2013? Thyroid. 2013;23(5):523–8.

    Article  CAS  PubMed  Google Scholar 

  12. Chung HR. Iodine and thyroid function. Ann Pediatr Endocrinol Metab. 2014;19(1):8–12.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Huang W, Peng C, Huang H, Zhang J, Liu J, Mao L, Luo R, Xiao Y. Control of iodine-deficiency disorders following universal salt iodization in Shenzhen, China, 1997–2011. Food Nutr Bull. 2013;34(3):331–7.

    Article  PubMed  Google Scholar 

  14. WHO/UNICEF/ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers [updated 1st September 2008]. 3rd ed. Geneva: World Health Organization; 2007.

    Google Scholar 

  15. Rohner F, Zimmermann M, Jooste P, Pandav C, Caldwell K, Raghavan R, Raiten DJ. Biomarkers of nutrition for development-Iodine review. J Nutr. 2014. pii:jn.113.181974.

    Google Scholar 

  16. Doggui R, El Atia J. Iodine deficiency: Physiological, clinical and epidemiological features, and pre-analytical considerations. Ann Endocrinol (Paris). 2015;76(1):59–66.

    Google Scholar 

  17. Girma K, Nibret E, Gedefaw M. The status of iodine nutrition and iodine deficiency disorders among school children in Metekel Zone. Northwest Ethiopia Ethiop J Health Sci. 2014;24(2):109–16.

    Article  PubMed  Google Scholar 

  18. Bath SC, Rayman MP. Iodine deficiency in the U.K.: an overlooked cause of impaired neurodevelopment? Proc Nutr Soc. 2013;72(2):226–35.

    Article  CAS  PubMed  Google Scholar 

  19. Andersson M, de Benoist B, Rogers L. Epidemiology of iodine deficiency: salt iodisation and iodine status. Best Pract Res Clin Endocrinol Metab. 2010;24(1):1–11.

    Article  CAS  PubMed  Google Scholar 

  20. Fuge R, Johnson CC. The geochemistry of iodine – a review. Environ Geochem Health. 1986;8(2):31–54.

    Article  CAS  PubMed  Google Scholar 

  21. Johnson CC. The geochemistry of iodine and its application to environmental strategies for reducing the risks from iodine deficiency disorders. British Geological Survey, CR/03/057N; 2003.

    Google Scholar 

  22. Leung AM, Braverman LE, Pearce EN. History of U.S. iodine fortification and supplementation. Nutrients. 2012;4:1740–6.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Gong T, Zhang X. Determination of iodide, iodate and organo-iodine in waters with a new total organic iodine measurement approach. Water Res. 2013;47(17):6660–9.

    Article  CAS  PubMed  Google Scholar 

  24. Kaplan DI, Denham ME, Zhang S, Yeager C, Xu C, Schwehr KA, Li HP, Ho YF, Wellman D, Santschi PH. Radioiodine biogeochemistry and prevalence in groundwater. Crit Rev Environ Sci Technol. 2014;44(20):2287–335.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Amachi S. Microbial contribution to global iodine cycling: volatilization, accumulation, reduction, oxidation, and sorption of iodine. Microbes Environ. 2008;23(4):269–76.

    Google Scholar 

  26. Chameides W, Davis D. Iodine: its possible role in tropospheric geochemistry. J Geophys Res. 1980;85:7383–98.

    Article  CAS  Google Scholar 

  27. Fuge R. The role of volatility in the distribution of iodine in the secondary environment. Appl Geochem. 1990;5:357–60.

    Article  Google Scholar 

  28. Fuge R. Sources of halogens in the environment, influences on human and animal health. Environ Geochem Health. 1988;10(2):51–61.

    Article  CAS  PubMed  Google Scholar 

  29. Hong C, Weng H, Jilani G, Yan A, Liu H, Xue Z. Evaluation of iodide and iodate for adsorption-desorption characteristics and bioavailability in three types of soil. Biol Trace Elem Res. 2012;146(2):262–71.

    Article  CAS  PubMed  Google Scholar 

  30. Hu Q, Zhao P, Moran JE, Seaman JC. Sorption and transport of iodine species in sediments from the Savannah River and Hanford Sites. J Contam Hydrol. 2005;78(3):185–205.

    Article  CAS  PubMed  Google Scholar 

  31. Kolb CE. Atmospheric chemistry: Iodine’s air of importance. Nature. 2002;417:597–8.

    Article  CAS  PubMed  Google Scholar 

  32. Gahche JJ, Bailey RL, Mirel LB, Dwyer JT. The prevalence of using iodine-containing supplements is low among reproductive-age women, NHANES 1999–2006. J Nutr. 2013;143(6):872–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Wolka E, Shiferaw S, Biadgilign S. Epidemiological study of risk factors for goiter among primary schoolchildren in southern Ethiopia. Food Nutr Bull. 2014;35(1):20–7.

    Article  PubMed  Google Scholar 

  34. Zimmerman MB, Jooste PL, Pandav CS. Iodine-deficiency disorders. Lancet. 2008;372:1251–62.

    Article  Google Scholar 

  35. Kuriti M, Pearce EN, Braverman LE, He X, Leung AM. Iodine content of U.S. weight-loss food. Endocr Pract. 2014;20(3):232–5.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Pearce EN. National trends in iodine nutrition: is everyone getting enough? Thyroid. 2007;17(9):823–7.

    Article  CAS  PubMed  Google Scholar 

  37. Pesce L, Kopp P. Iodide transport: implications for health and disease. Int J Pediatr Endocrinol. 2014;1:8. doi:10.1186/1687-9856-2014-8.

    Article  Google Scholar 

  38. Sellitti DF, Suzuki K. Intrinsic regulation of thyroid function by thyroglobulin. Thyroid. 2014;24(4):625–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Nicola JP, Reyna-Neyra A, Carrasco N, Masini-Repiso AM. Dietary iodide controls its own absorption through post-transcriptional regulation of the intestinal Na+/I- symporter. J Physiol. 2012;590(Pt 23):6013–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Portulano C, Paroder-Belenitsky M, Carrasco N. The Na+/I- Symporter (NIS): mechanism and medical impact. Endocr Rev. 2014;35(1):106–49.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Schweizer U, Johannes J, Bayer D, Braun D. Structure and function of thyroid hormone plasma membrane transporters. Eur Thyroid J. 2014;3(3):143–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Bürgi H. Iodine excess. Best Pract Res Clin Endocrinol Metab. 2010;24:107–15.

    Article  PubMed  Google Scholar 

  43. Vargas-Uricoechea H, Sierra-Torres CH. Thyroid hormones and the heart. Horm Mol Biol Clin Investig. 2014;18(1):15–26.

    CAS  PubMed  Google Scholar 

  44. Leung AM, Braverman LE. Consequences of excess iodine. Nat Rev Endocrinol. 2014;10(3):136–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Bizhanova A, Kopp P. Minireview: the sodium-iodide symporter NIS and PDS in iodide homeostasis of the thyroid. Endocrinology. 2009;150:1084–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Sun X, Shan Z, Teng W. Effects of increased iodine intake on thyroid disorders. Endocrinol Metab (Seoul). 2014;29(3):240–7.

    Article  Google Scholar 

  47. Vargas-Uricoechea H, Bonelo-Perdomo A, Sierra-Torres CH. Effects of thyroid hormones on the heart. Clin Invest Arterioscl. 2014;26(6):296–309.

    Google Scholar 

  48. Roti E, Uberti ED. Iodine excess and hyperthyroidism. Thyroid. 2001;11(5):493–500.

    Article  CAS  PubMed  Google Scholar 

  49. Mansourian ARA. review on the metabolic disorders of iodine deficiency. Pak J Biol Sci. 2011;14(7):412–24.

    Article  PubMed  Google Scholar 

  50. Kawicka A, Regulska-Ilow B, Regulska-Ilow B. Metabolic disorders and nutritional status in autoimmune thyroid diseases. Postepy Hig Med Dosw (Online). 2015;69:80–90.

    Article  Google Scholar 

  51. Yang X, Gao T, Shi R, Zhou X, Qu J, Xu J, Shan Z, Teng W. Effect of iodine excess on Th1, Th2, Th17, and Treg cell subpopulations in the thyroid of NOD.H-2 h4 mice. Biol Trace Elem Res. 2014;159(1–3):288–96.

    Article  CAS  PubMed  Google Scholar 

  52. World Health Organization, United Nations Children’s Fund, International Council for the Control of Iodine Deficiency Disorders. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. Geneva: World Health Organization; 2007.

    Google Scholar 

  53. Zhou SJ, Anderson AJ, Gibson RA, Makrides M. Effect of iodine. supplementation in pregnancy on child development and other clinical outcomes: a systematic review of randomized controlled trials. Am J Clin Nutr. 2013;98(5):1241–54.

    Article  CAS  PubMed  Google Scholar 

  54. Zimmerman MB. Assessing iodine status and monitoring progress of iodized salt programs. J Nutr. 2004;134:1673–7.

    Google Scholar 

  55. Zimmermann MB, Hess SY, Molinari L, De Benoist B, Delange F, Braverman LE, Fujieda K, Ito Y, Jooste PL, Moosa K, Pearce EN, Pretell EA, Shishiba Y. New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report. Am J Clin Nutr. 2004;79(2):231–7.

    CAS  PubMed  Google Scholar 

  56. Vargas-Uricoechea H, Sierra-Torres CH, Holguín-Betancourt CM, Cristancho-Torres L. Iodine-deficiency disorders. Permanent surveillance of vulnerable zones is poor. MEDICINA. (Bogotá). 2012;34, No. 2(97):119–44.

    Google Scholar 

  57. Taylor PN, Okosieme OE, Dayan CM, Lazarus JH. Therapy of endocrine disease: impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis. Eur J Endocrinol. 2014;170:R1–15.

    Article  CAS  PubMed  Google Scholar 

  58. WHO. Guideline: fortification of food-grade salt with iodine for the prevention and control of iodine deficiency disorders. Geneva: World Health Organization; 2014.

    Google Scholar 

  59. Aburto N, Abudou M, Candeias V, Wu T. Effect and safety of salt iodization to prevent iodinedeficiency disorders: a systematic review with meta-analyses. WHO eLibrary of EvidenceforNutrition Actions (eLENA). Geneva: World Health Organization; 2014.

    Google Scholar 

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Correspondence to Hernando Vargas-Uricoechea MD, MSc, Ph.Dc .

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Vargas-Uricoechea, H., Bonelo-Perdomo, A., Sierra-Torres, C.H. (2016). Iodine and the Thyroid. In: Imam, S., Ahmad, S. (eds) Thyroid Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-25871-3_3

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  • DOI: https://doi.org/10.1007/978-3-319-25871-3_3

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